F13B gene related symptoms and diseases

All the information presented here about the F13B gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,NCBIGENE,ORPHANET,HGNC, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to F13B gene

Symptoms // Phenotype % Cases
Bruising susceptibility Very Common - Between 80% and 100% cases
Abnormal bleeding Very Common - Between 80% and 100% cases
Ecchymosis Very Common - Between 80% and 100% cases
Poor wound healing Very Common - Between 80% and 100% cases
Prolonged bleeding after surgery Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with F13B gene alterations may also develop some of the following symptoms and phenotypes:
  • Commonly - More than 50% cases

  • Abnormal umbilical stump bleeding
  • Reduced factor XIII activity
  • Not very common - Between 30% and 50% cases

  • Decreased testicular size
  • Epistaxis
  • Spontaneous abortion
  • Intracranial hemorrhage
  • Menorrhagia
  • Oligospermia

And 3 more phenotypes, you can get all of them using our tools for rare diseases.

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Rare diseases associated to F13B gene

Here you will find a list of rare diseases related to the F13B. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


CONGENITAL FACTOR XIII DEFICIENCY


Alternate names

CONGENITAL FACTOR XIII DEFICIENCY Is also known as fibrin-stabilizing factor deficiency

Description

Congenital factor XIII deficiency is an inherited bleeding disorder due to reduced levels and activity of factor XIII (FXIII) and characterized by hemorrhagic diathesis frequently associated with spontaneous abortions and defective wound healing. Factor XIII deficiency is one of the most rare coagulation factor deficiencies.

Most common symptoms of CONGENITAL FACTOR XIII DEFICIENCY

  • Bruising susceptibility
  • Abnormal bleeding
  • Ecchymosis
  • Poor wound healing
  • Prolonged bleeding after surgery


More info about CONGENITAL FACTOR XIII DEFICIENCY

SOURCES: ORPHANET OMIM

FACTOR XIII, A SUBUNIT, DEFICIENCY OF


Description

Factor XIII deficiency is an autosomal recessive hematologic disorder characterized by increased bleeding and poor wound healing. Most cases of congenital factor XIII deficiency result from mutation in the A subunit (Kangsadalampai et al., 1999).{21,22:Ichinose et al. (1996, 2000)} proposed a classification of factor XIII deficiency: XIIIA deficiency (formerly 'type II' F13 deficiency) and XIIIB deficiency (formerly 'type I' F13 deficiency), as well as a possible combined deficiency of the 2.

Most common symptoms of FACTOR XIII, A SUBUNIT, DEFICIENCY OF

  • Bruising susceptibility
  • Abnormal bleeding
  • Decreased testicular size
  • Epistaxis
  • Spontaneous abortion


More info about FACTOR XIII, A SUBUNIT, DEFICIENCY OF

SOURCES: OMIM


Potential gene panels for F13B gene

Factor XIII Deficiency Panel

United Kingdom.

By Sheffield Diagnostic Genetics Service Sheffield Children's NHS Foundation Trust Factor XIII Deficiency that also includes the following genes: F13A1 F13B

More info about this panel

F13B. Complete sequencing Panel

Spain.

By Instituto de Medicina Genomica Instituto de Medicina Genomica

This panel specifically test the F13B gene.

More info about this panel

Factor XIII deficiency (sequence analysis of F13B gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the F13B gene.

More info about this panel

Bleeding Disorders Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Bleeding Disorders Sequencing Panel with CNV Detection that also includes the following genes: RUNX1 TBXA2R TBXAS1 VWF WAS ADAMTS13 ABCG5 ABCG8 GP6 HPS3

More info about this panel

Coagulation Factor Deficiency Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Coagulation Factor Deficiency Sequencing Panel with CNV Detection that also includes the following genes: VWF MCFD2 VKORC1 F10 F11 F12 F13A1 F13B F2 F5

More info about this panel

Congenital Factor XIII Deficiency via F13B Gene Sequencing with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics

This panel specifically test the F13B gene.

More info about this panel

Factor XIIIB deficiency Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the F13B gene.

More info about this panel

F13A1 & F13B gene analysis Panel

United Kingdom.

By Molecular Haemostasis & Thrombosis GSTS Pathology - Guy's and St. Thomas' NHS Foundation Trust F13A1 & F13B gene analysis that also includes the following genes: F13A1 F13B

More info about this panel

F13B Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the F13B gene.

More info about this panel

Comprehensive Hematology Panel Panel

Finland.

By Blueprint Genetics Comprehensive Hematology Panel that also includes the following genes: RHAG RIT1 RPL11 RPL15 RPL35A RPL5 RPS10 RPS19 RPS24 RPS26

More info about this panel

Factor XIII, deficiency Panel

Spain.

By Bioarray

This panel specifically test the F13B gene.

More info about this panel

FACTOR XIII DEFICIENCY Panel

Spain.

By Laboratorio de Genetica Clinica SL FACTOR XIII DEFICIENCY that also includes the following genes: F13A1 F13B

More info about this panel

Factor XIIIB Deficiency , Sequencing F13B Gene Panel

Spain.

By Reference Laboratory Genetics

This panel specifically test the F13B gene.

More info about this panel

Thrombophilia due to Factor XIII Deficiency , Massive Sequencing (NGS) F13A1, F13B Genes Panel

Spain.

By Reference Laboratory Genetics Thrombophilia due to Factor XIII Deficiency , Massive Sequencing (NGS) F13A1, F13B Genes that also includes the following genes: F13A1 F13B

More info about this panel


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