CASP10 gene related symptoms and diseases

All the information presented here about the CASP10 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: HGNC,OMIM,ORPHANET,NCBIGENE, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to CASP10 gene

Symptoms // Phenotype % Cases
Neoplasm Common - Between 50% and 80% cases
Anemia Uncommon - Between 30% and 50% cases
Antineutrophil antibody positivity Uncommon - Between 30% and 50% cases
Follicular hyperplasia Uncommon - Between 30% and 50% cases
Increased IgM level Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with CASP10 gene alterations may also develop some of the following symptoms and phenotypes:
  • Not very common - Between 30% and 50% cases

  • Autoimmune neutropenia
  • Increased IgG level
  • Reduced delayed hypersensitivity
  • Coombs-positive hemolytic anemia
  • Rheumatoid factor positive
  • Platelet antibody positive
  • Decreased lymphocyte apoptosis
  • Increased IgA level

And 62 more phenotypes, you can get all of them using our tools for rare diseases.

Mendelian

Accelerate your rare disease diagnosis with us

Learn more

Rare diseases associated to CASP10 gene

Here you will find a list of rare diseases related to the CASP10. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IIA; ALPS2A


Alternate names

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IIA; ALPS2A Is also known as alps2, autoimmune lymphoproliferative syndrome, type ii

Most common symptoms of AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IIA; ALPS2A

  • Anemia
  • Hepatomegaly
  • Fever
  • Splenomegaly
  • Thrombocytopenia


More info about AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IIA; ALPS2A

SOURCES: OMIM MESH

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME


Alternate names

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME Is also known as alps, autoimmune lymphoproliferative syndrome, type i, autosomal dominant, fas deficiency, canale-smith syndrome

Description

Autoimmune lymphoproliferative syndrome (ALPS) is a rare, inherited disorder characterized by non-malignant lymphoproliferation, multilineage cytopenias, and a lifelong increased risk of Hodgkin's and non-Hodgkin's lymphoma.

Most common symptoms of AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME

  • Neoplasm
  • Anemia
  • Hepatomegaly
  • Edema
  • Splenomegaly


More info about AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME

SOURCES: OMIM ORPHANET

NON-HODGKIN LYMPHOMA


Alternate names

NON-HODGKIN LYMPHOMA Is also known as nhl, non-hodgkin lymphoma

Description

Non-Hodgkin malignant lymphomas(NHL) is a heterogeneous group of malignant tumors of the lymphoid system.

Most common symptoms of NON-HODGKIN LYMPHOMA

  • Neoplasm
  • Leukemia
  • Lymphoma
  • Hodgkin lymphoma
  • B-cell lymphoma


More info about NON-HODGKIN LYMPHOMA

SOURCES: ORPHANET OMIM

GASTRIC CANCER


Description

In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several genes may be associated with an increased risk of gastric cancer.Gastric cancer is a manifestation of a number of inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (HNPCC1; see {120435}), familial adenomatous polyposis (FAP ), Peutz-Jeghers syndrome (PJS ), Cowden disease (CD ), and the Li-Fraumeni syndrome (OMIM ). See also hereditary diffuse gastric cancer (HDGC ).Canedo et al. (2007) provided a review of genetic susceptibility to gastric cancer in patients infected with Helicobacter pylori (see {600263}).

Most common symptoms of GASTRIC CANCER

  • Neoplasm
  • Carcinoma
  • Nephroblastoma
  • Colon cancer
  • Neoplasm of the lung


More info about GASTRIC CANCER

SOURCES: OMIM ORPHANET


Potential gene panels for CASP10 gene

CASP10 Sequencing Panel

United States.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center

This panel specifically test the CASP10 gene.

More info about this panel

Autoimmune Lymphoproliferative Syndrome Panel by next-generation sequencing (NGS) Panel

United States.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center Autoimmune Lymphoproliferative Syndrome Panel by next-generation sequencing (NGS) that also includes the following genes: FAS FASLG CASP10 CASP8 MAGT1 FADD ITK KRAS NRAS

More info about this panel

Autoimmune Lymphoproliferative Syndrome Deletion/Duplication Panel Panel

United States.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center Autoimmune Lymphoproliferative Syndrome Deletion/Duplication Panel that also includes the following genes: FAS FASLG CASP10 CASP8 MAGT1 FADD ITK KRAS NRAS

More info about this panel

CASP10 Deletion/duplication analysis Panel

United States.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center

This panel specifically test the CASP10 gene.

More info about this panel

Tier 2: Hereditary Lymphoma and Immunodeficiency Panel Panel

United States.

By Genetic Services Laboratory University of Chicago Tier 2: Hereditary Lymphoma and Immunodeficiency Panel that also includes the following genes: BLM SH2D1A BRCA1 BRCA2 STXBP2 FAS CD27 FASLG WAS IKZF1

More info about this panel

CASP10. Complete sequencing Panel

Spain.

By Instituto de Medicina Genomica Instituto de Medicina Genomica

This panel specifically test the CASP10 gene.

More info about this panel

Autoimmune lymphoproliferative syndrome type II (sequence analysis of CASP10 gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the CASP10 gene.

More info about this panel

Autoimmune Lymphoproliferative Syndrome/ALPS Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Autoimmune Lymphoproliferative Syndrome/ALPS Sequencing Panel with CNV Detection that also includes the following genes: SH2D1A STAT3 FAS FASLG CASP10 CASP8 LRBA CTLA4 MAGT1 FADD

More info about this panel

CASP10 Panel

Netherlands.

By Genome Diagnostics Laboratory University Medical Center Utrecht

This panel specifically test the CASP10 gene.

More info about this panel

ALPS/autoimmunity panel Panel

Netherlands.

By Genome Diagnostics Laboratory University Medical Center Utrecht ALPS/autoimmunity panel that also includes the following genes: FAS FASLG ITCH CASP10 CASP8 LRBA FADD AIRE IL2RA FOXP3

More info about this panel

Autoimmune lymphoproliferative syndrome Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the CASP10 gene.

More info about this panel

Bone marrow failure syndromes with Leukemia Panel Panel

Germany.

By CeGaT GmbH Bone marrow failure syndromes with Leukemia Panel that also includes the following genes: RUNX1 CASP10 CEBPA GATA1 NBN

More info about this panel

Immune dysregulation Panel Panel

Germany.

By CeGaT GmbH Immune dysregulation Panel that also includes the following genes: SH2D1A STX11 STXBP2 FAS FASLG TREX1 ITCH CASP10 CASP8 CARD11

More info about this panel

Invitae Monogenic Autoimmunity Panel Panel

United States.

By Invitae Invitae Monogenic Autoimmunity Panel that also includes the following genes: RMRP SH2D1A SLC7A7 BTK STAT1 STAT3 STAT5B STIM1 STX11 STXBP2

More info about this panel

Invitae Primary Immunodeficiency Panel Panel

United States.

By Invitae Invitae Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC SEMA3E SH2D1A SH3BP2 SLC7A7 SMARCAL1 BTK STAT1 STAT2

More info about this panel

CASP10 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the CASP10 gene.

More info about this panel

Primary Immunodeficiency Panel Panel

Finland.

By Blueprint Genetics Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC CFB BLM SH2D1A SLC7A7 SMARCAL1 SMARCD2 SRP72 BTK

More info about this panel

Autoimmune lymphoproliferative syndrome type 2A Panel

Spain.

By Bioarray

This panel specifically test the CASP10 gene.

More info about this panel

LYMPHOPROLIFERATIVE SYNDROME, AUTOIMMUNE Panel

Spain.

By Laboratorio de Genetica Clinica SL LYMPHOPROLIFERATIVE SYNDROME, AUTOIMMUNE that also includes the following genes: FAS FASLG CASP10 CASP8 NRAS

More info about this panel

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME NGS PANEL Panel

Spain.

By Laboratorio de Genetica Clinica SL AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME NGS PANEL that also includes the following genes: SH2D1A STAT3 FAS FASLG CASP10 CASP8 CTLA4 MAGT1 FADD XIAP

More info about this panel

Autoimmune Lymphoproliferative Syndrome Type II, Sequencing CASP10 Gene Panel

Spain.

By Reference Laboratory Genetics

This panel specifically test the CASP10 gene.

More info about this panel

Autosomic Autoimmune Lymphoproliferative Syndrome , Panel Massive Sequencing (NGS) 10 Genes Panel

Spain.

By Reference Laboratory Genetics Autosomic Autoimmune Lymphoproliferative Syndrome , Panel Massive Sequencing (NGS) 10 Genes that also includes the following genes: FAS FASLG CASP10 CASP8 CTLA4 MAGT1 FADD ITK KRAS NRAS

More info about this panel


If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like CACNA1C KMT5B CLN6 MT-TV GLUL

Need help with a diagnosis?

Learn more about how to achieve it with Mendelian


Learn more