CARD11 gene related symptoms and diseases
All the information presented here about the CARD11 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,OMIM,ORPHANET,HGNC, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to CARD11 gene
Symptoms // Phenotype | % Cases |
---|---|
Recurrent infections | Common - Between 50% and 80% cases |
Immunodeficiency | Common - Between 50% and 80% cases |
Lymphoma | Uncommon - Between 30% and 50% cases |
Decreased antibody level in blood | Uncommon - Between 30% and 50% cases |
Respiratory tract infection | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with CARD11 gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Hepatomegaly
- Lymphadenopathy
- T-cell lymphoma
- Splenomegaly
- Pneumonia
Rarely - Less than 30% cases
- Chronic lymphatic leukemia
- IgM deficiency
- Neoplasm
And 51 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to CARD11 gene
Here you will find a list of rare diseases related to the CARD11. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
SÉZARY SYNDROME
Alternate names
SÉZARY SYNDROME Is also known as sÉzary lymphoma
Description
Sézary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma characterized by a triad of erythroderma, lymphadenopathy and circulating atypical lymphocytes (Sézary cells).
Most common symptoms of SÉZARY SYNDROME
- Neoplasm
- Abnormal facial shape
- Peripheral neuropathy
- Hepatomegaly
- Fever
More info about SÉZARY SYNDROME
BENTA DISEASE
Alternate names
BENTA DISEASE Is also known as b-cell expansion with nf-kb and t-cell anergy disease
More info about BENTA DISEASE
SOURCES: ORPHANET
PERSISTENT POLYCLONAL B-CELL LYMPHOCYTOSIS
Alternate names
PERSISTENT POLYCLONAL B-CELL LYMPHOCYTOSIS Is also known as persistent polyclonal b-cell lymphocytosis with binucleated lymphocytes, ppbl
Description
Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare, generally benign, lymphoproliferative hematological disease characterized by: chronic, stable, persistent, polyclonal lymphocytosis of memory B-cell origin, the presence of binucleated lymphocytes in the peripheral blood, and a polyclonal increase in serum immunoglobulin M (IgM). Patients are most frequently asymptomatic or may present with mild splenomegaly.
Most common symptoms of PERSISTENT POLYCLONAL B-CELL LYMPHOCYTOSIS
- Anemia
- Hepatomegaly
- Splenomegaly
- Immunodeficiency
- Recurrent infections
More info about PERSISTENT POLYCLONAL B-CELL LYMPHOCYTOSIS
SEVERE COMBINED IMMUNODEFICIENCY DUE TO CARD11 DEFICIENCY
Alternate names
SEVERE COMBINED IMMUNODEFICIENCY DUE TO CARD11 DEFICIENCY Is also known as scid due to card11 deficiency, card11 immunodeficiency, imd11, immunodeficiency 11
Description
Severe combined immunodeficiency due to CARD11 deficiency is a rare combined T and B cell immunodeficiency characterized by normal numbers of T and B lymphocytes, increased numbers of transitional B cells and hypo- to agammaglobulinemia, decreased numbers of regulatory T cells and defects in T-cell functions. It presents with severe susceptibility to infections, including opportunistic infections.
Most common symptoms of SEVERE COMBINED IMMUNODEFICIENCY DUE TO CARD11 DEFICIENCY
- Immunodeficiency
- Recurrent infections
- Pneumonia
- Recurrent respiratory infections
- Respiratory tract infection
More info about SEVERE COMBINED IMMUNODEFICIENCY DUE TO CARD11 DEFICIENCY
IMMUNODEFICIENCY 11B WITH ATOPIC DERMATITIS; IMD11B
Alternate names
IMMUNODEFICIENCY 11B WITH ATOPIC DERMATITIS; IMD11B Is also known as atopic dermatitis, elevated ige, and eosinophilia
Description
IMD11B is an autosomal dominant disorder of immune dysfunction characterized by onset of moderate to severe atopic dermatitis in early childhood. Some patients may have recurrent infections and other variable immune abnormalities. Laboratory studies show defects in T-cell activation, increased IgE, and eosinophilia (summary by Ma et al., 2017).
Most common symptoms of IMMUNODEFICIENCY 11B WITH ATOPIC DERMATITIS; IMD11B
- Recurrent infections
- Pneumonia
- Asthma
- Lymphoma
- Decreased antibody level in blood
More info about IMMUNODEFICIENCY 11B WITH ATOPIC DERMATITIS; IMD11B
SOURCES: OMIM
Search interest in CARD11
Potential gene panels for CARD11 gene
Tier 2: Hereditary Lymphoma and Immunodeficiency Panel Panel
By Genetic Services Laboratory University of Chicago Tier 2: Hereditary Lymphoma and Immunodeficiency Panel that also includes the following genes: BLM SH2D1A BRCA1 BRCA2 STXBP2 FAS CD27 FASLG WAS IKZF1
More info about this panelCentoICU platinum plus Panel
By Centogene AG - the Rare Disease Company CentoICU platinum plus that also includes the following genes: RMRP BCS1L BDNF RPS19 RPS6KA3 SALL1 SCN1A SCN2A SFTPB SFTPC
More info about this panelNew Born testing (CentoICU) Panel
By Centogene AG - the Rare Disease Company New Born testing (CentoICU) that also includes the following genes: RMRP BCS1L BDNF RPS19 RPS6KA3 SALL1 SCN1A SCN2A SFTPB SFTPC
More info about this panelB-cell expansion with NFKB and T-cell anergy Panel
By Centogene AG - the Rare Disease Company
This panel specifically test the CARD11 gene.
More info about this panelImmunodeficiency type 11 Panel
By Centogene AG - the Rare Disease Company
This panel specifically test the CARD11 gene.
More info about this panelImmune dysregulation Panel Panel
By CeGaT GmbH Immune dysregulation Panel that also includes the following genes: SH2D1A STX11 STXBP2 FAS FASLG TREX1 ITCH CASP10 CASP8 CARD11
More info about this panelCombined immunodeficiencies Panel Panel
By CeGaT GmbH Combined immunodeficiencies Panel that also includes the following genes: RMRP SEMA3E STAT5B STIM1 STK4 TAPBP TBX1 THBD TNFRSF4 CD40
More info about this panelInvitae Comprehensive Severe Combined Immunodeficiency (SCID) and Combined Immunodeficiency (CID) Panel Panel
By Invitae Invitae Comprehensive Severe Combined Immunodeficiency (SCID) and Combined Immunodeficiency (CID) Panel that also includes the following genes: STK4 TAPBP TNFRSF4 CD27 CD40LG ZAP70 CARD11 CD3D CD3E CD3G
More info about this panelInvitae Primary Immunodeficiency Panel Panel
By Invitae Invitae Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC SEMA3E SH2D1A SH3BP2 SLC7A7 SMARCAL1 BTK STAT1 STAT2
More info about this panelInvitae Combined Immunodeficiency (CID) Panel Panel
By Invitae Invitae Combined Immunodeficiency (CID) Panel that also includes the following genes: STK4 TAPBP TNFRSF4 CD27 CD40LG ZAP70 CARD11 CD3G CD8A LRBA
More info about this panelCARD11 Panel
By Fulgent Genetics Fulgent Genetics
This panel specifically test the CARD11 gene.
More info about this panelPrimary Immunodeficiency Panel Panel
By Blueprint Genetics Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC CFB BLM SH2D1A SLC7A7 SMARCAL1 SMARCD2 SRP72 BTK
More info about this panelSevere Combined Immunodeficiency Panel Panel
By Blueprint Genetics Severe Combined Immunodeficiency Panel that also includes the following genes: RMRP BLM SH2D1A SMARCAL1 STAT1 STAT2 STAT3 STAT5B STIM1 STK4
More info about this panelFocus::CLL™ NGS Panel Panel
By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::CLL™ NGS Panel that also includes the following genes: SF3B1 BRAF BTK MED12 TP53 TRAF2 XPO1 ZMYM3 IKZF3 CARD11
More info about this panelFocus::DLBCL&FL™ NGS Panel Panel
By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::DLBCL&FL™ NGS Panel that also includes the following genes: BCL6 SGK1 BRAF ARID1A BTK STAT3 STAT6 SYK TNFAIP3 FAS
More info about this panelFocus::Lymphoma™ NGS Panel Panel
By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::Lymphoma™ NGS Panel that also includes the following genes: BCL6 SGK1 BRAF ARID1A BTK STAT3 STAT6 SYK TNFAIP3 FAS
More info about this panelFoundationOne® Heme Panel
By Foundation Medicine, Inc. FoundationOne® Heme that also includes the following genes: BCL6 BCL7A ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1
More info about this panelNeoTYPE® Discovery Profile for Solid Tumors Panel
By NeoGenomics Laboratories NeoGenomics Laboratories, Inc. NeoTYPE® Discovery Profile for Solid Tumors that also includes the following genes: BCL6 ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1 FOXL2
More info about this panelCaris MI TumorSeek 592-Gene NGS Panel Panel
By Caris Life Sciences Caris MI TumorSeek 592-Gene NGS Panel that also includes the following genes: BCL6 BCL7A BCL9 BCR ROS1 RPL10 RPL22 RPL5 RPN1 RUNX1
More info about this panelSEVERE COMBINED IMMUNODEFICIENCY (SCID): NGS PANEL Panel
By Laboratorio de Genetica Clinica SL SEVERE COMBINED IMMUNODEFICIENCY (SCID): NGS PANEL that also includes the following genes: STAT1 STIM1 FOXN1 ZAP70 CARD11 CD3D CD3E CD247 DCLRE1C ADA
More info about this panelProvidence Personalized Medicine Panel - Solid Tumor Panel
By Providence Regional Laboratories Providence Health and Services Providence Personalized Medicine Panel - Solid Tumor that also includes the following genes: BCR ROS1 RUNX1 SDHA SDHB SDHC SDHD SF3B1 SRSF2 FOXL2
More info about this panelTempus xT assay Panel
By Tempus Labs, Inc. Tempus xT assay that also includes the following genes: BCL6 RIT1 BCL7A BCR ROS1 RPL5 RPS15 RPS6KB1 RUNX1 RXRA
More info about this panelTempus xO assay Panel
By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2
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