Osteosarcoma

Description

Osteosarcoma is a primary malignant tumour of the skeleton characterised by the direct formation of immature bone or osteoid tissue by the tumour cells.

Clinical Features

Top most frequent phenotypes and symptoms related to Osteosarcoma

  • Pain
  • Fever
  • Weight loss
  • Abnormality of the metaphysis
  • Osteolysis
  • Elevated alkaline phosphatase
  • Pathologic fracture
  • Joint swelling
  • Abnormal lactate dehydrogenase activity
  • Increased lactate dehydrogenase activity

And another 2 symptoms. If you need more information about this disease we can help you.

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Incidence and onset information

— Based on the latest data available Osteosarcoma have a estimated incidence of 0.23 per 100k worldwide.
No data available about the known clinical features onset.

Alternative names

Osteosarcoma Is also known as osteogenic sarcoma.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.


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Osteosarcoma Recommended genes panels

Panel Name, Specifity and genes Tested/covered
TP53 Comprehensive - Sequence & Deletion/Duplication Analysis.

By Baylor Miraca Genetics Laboratories (United States).

TP53
Specificity
100 %
Genes
34 %
TP53 Deletion/Duplication Analysis.

By Baylor Miraca Genetics Laboratories (United States).

TP53
Specificity
100 %
Genes
34 %
TP53 Sequence Analysis.

By Baylor Miraca Genetics Laboratories (United States).

TP53
Specificity
100 %
Genes
34 %
TP53 Sequence Analysis (Familial Mutation/Variant Analysis).

By Baylor Miraca Genetics Laboratories (United States).

TP53
Specificity
100 %
Genes
34 %
MitoMetĀ®Plus aCGH Analysis.

By Baylor Miraca Genetics Laboratories (United States).

RGS9, RHO, GRK1, RLBP1, RNASEL, BCS1L, RP1, RP2, RP9, RPE65, RPGR, RPL35A, MRPL3, RPS14, RS1, SAG, SARDH, SCO2, SCP2, SDHB , (...)

View the complete list with 612 more genes
Specificity
1 %
Genes
67 %
Hereditary Brain, CNS, PNS Cancer Panel.

By Baylor Miraca Genetics Laboratories (United States).

TP53, VHL, SUFU, PALB2, ALK, APC, MEN1, MLH1, MRE11, MSH2, MSH6, NBN, NF2, ATM, PMS2, PHOX2B, PTCH1
Specificity
6 %
Genes
34 %
Hereditary High Risk Breast Cancer Panel.

By Baylor Miraca Genetics Laboratories (United States).

BRCA1, BRCA2, STK11, TP53, CDH1, PALB2, PTEN
Specificity
15 %
Genes
34 %
Hereditary Brain, CNS, PNS Cancer Panel.

By Baylor Miraca Genetics Laboratories (United States).

TP53, VHL, SUFU, PALB2, ALK, APC, MEN1, MLH1, MRE11, MSH2, MSH6, NBN, NF2, ATM, PMS2, PHOX2B, PTCH1
Specificity
6 %
Genes
34 %

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Sources and references

You can check the following sources for additional information.

ORPHANET Rare Disease Symptoms Checker

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