Migraine With Or Without Aura, Susceptibility To, 1


Migraine is the most common type of chronic, episodic headache, as summarized by Featherstone (1985).One locus for migraine with or without aura (MGR1) has been identified on chromosome 4q24. Other loci for migraine have been identified on 6p21.1-p12.2 (MGR3 ), 14q21.2-q22.3 (MGR4 ), 19p13 (MGR5 ), 1q31 (MGR6 ), 15q11-q13 (MGR7 ), 5q21 (with or without aura, MGR8, {609570}; with aura, MGR9, {609670}), 17p13 (MGR10 ), 18q12 (MGR11 ), 10q22-q23 (MGR12 ), and the X chromosome (MGR2 ).Mutation in the KCNK18 gene (OMIM ) on chromosome 10q25 causes migraine with aura (MGR13 ).A subtype of autosomal dominant migraine with aura (MA), familial hemiplegic migraine (FHM; see {141500}), is caused by mutation in the CACNA1A gene (OMIM ) on chromosome 19p13 (FHM1 ), by mutation in the ATP1A2 gene (OMIM ) on chromosome 1q21 (FHM2 ), or by mutation in the SCN1A gene (OMIM ) on chromosome 2q24 (FHM3 ). Another locus for FHM has been mapped to chromosome 1q31 (FHM4; see {607516}).There is evidence that a polymorphism in the estrogen receptor gene (ESR1; {133430.0005}) and a polymorphism in the TNF gene ({191160.0004}) may confer susceptibility to migraine. A polymorphism in the endothelin receptor type A gene (EDNRA; {131243.0001}) may confer resistance to migraine.

Clinical Features

Phenotypes and symptoms related to Migraine With Or Without Aura, Susceptibility To, 1

  • Seizures
  • Pain
  • Vomiting
  • Headache
  • Photophobia
  • Nausea
  • Migraine
  • Migraine with aura
  • Phonophobia
  • Migraine without aura

Incidence and onset information

Not enough data available about incidence and published cases.
No data available about the known clinical features onset.

Alternative names

Migraine With Or Without Aura, Susceptibility To, 1 Is also known as mgau, migraine, mgr1, ma.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.


Accelerate your rare disease diagnosis with us

Learn more

Sources and references

You can check the following sources for additional information.

OMIM Genetic Syndrome Finder

If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 1; SCAR1 SHORT SLEEPER

Need help with a diagnosis?

Learn more about how to achieve it with Mendelian

Learn more