Chordoma, Susceptibility To; Chdm

Description

Chordomas are rare, clinically malignant tumors derived from notochordal remnants. They occur along the length of the spinal axis, predominantly in the sphenooccipital, vertebral, and sacrococcygeal regions. They are characterized by slow growth, local destruction of bone, extension into adjacent soft tissues, and, rarely, distant metastatic spread (Stepanek et al., 1998). The incidence of chordoma is age-dependent, with fewer than 5% occurring in children and adolescents (summary by McMaster et al., 2011).

Clinical Features

Phenotypes and symptoms related to Chordoma, Susceptibility To; Chdm

  • Neoplasm
  • Nevus
  • Acrania
  • Abnormality of the vertebral column
  • Abnormality of the head
  • Chordoma

Incidence and onset information

Not enough data available about incidence and published cases.


Mendelian

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Chordoma, Susceptibility To; Chdm Recommended genes panels

Panel Name, Specifity and genes Tested/covered
T.

By Fulgent Genetics Fulgent Genetics in United States.

TBXT
Specificity
100 %
Genes
100 %

Alternate names

Chordoma, Susceptibility To; Chdm Is also known as ;notochordal sarcoma.


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