Colorectal Cancer, Susceptibility To, 12; Crcs12

Table of contents:

Description
Related genes
Clinical Features
Incidence and onset information
Alternative Names
Researches and researchers
Gene Panels
Sources and references

Description

Colorectal cancer-12 is an autosomal dominant disorder characterized by a high-penetrance predisposition to the development of colorectal adenomas and carcinomas, with a variable tendency to develop multiple and large tumors. Onset usually occurs before age 40 years. The histologic features of the tumors may be unremarkable (Palles et al., 2013) or show microsatellite instability (MSI) (Elsayed et al., 2015).For a general phenotypic description and a discussion of genetic heterogeneity of colorectal cancer, see {114500}.

Genes related to Colorectal Cancer, Susceptibility To, 12; Crcs12

POLE

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Clinical Features

Phenotypes and symptoms related to Colorectal Cancer, Susceptibility To, 12; Crcs12

Neoplasm
Carcinoma
Colon cancer
Colorectal polyposis

Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
— No data available about the known clinical features onset.

Alternative names

Colorectal Cancer, Susceptibility To, 12; Crcs12 Is also known as colorectal cancer, susceptibility to, on chromosome 12q24.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.

Colorectal Cancer, Susceptibility To, 12; Crcs12 Recommended genes panels

Panel Name, Specifity and genes Tested/covered
VistaSeq Colorectal Cancer Panel. By Molecular Diagnostic Laboratory University of Alberta (Canada). BLM, BMPR1A, BRCA1, BRCA2, STK11, EPCAM, TP53, CDH1, CDKN2A, APC, SMAD4, MLH1, MSH2, MSH6, MUTYH, ATM, AXIN2, PMS2, POLD1, POLE , (...) View the complete list with 1 more genes Panel complete gene list BLM, BMPR1A, BRCA1, BRCA2, STK11, EPCAM, TP53, CDH1, CDKN2A, APC, SMAD4, MLH1, MSH2, MSH6, MUTYH, ATM, AXIN2, PMS2, POLD1, POLE, PTEN Specificity 5 % Genes 100 %
myRisk Hereditary Cancer. By Myriad Genetic Laboratories, Inc. Myriad Genetic Laboratories, Inc. (United States). BMPR1A, BRCA1, BRCA2, STK11, EPCAM, TP53, CDH1, CDK4, CDKN2A, GREM1, BRIP1, PALB2, APC, SMAD4, MLH1, MSH2, MSH6, MUTYH, NBN, ATM , (...) View the complete list with 7 more genes Panel complete gene list BMPR1A, BRCA1, BRCA2, STK11, EPCAM, TP53, CDH1, CDK4, CDKN2A, GREM1, BRIP1, PALB2, APC, SMAD4, MLH1, MSH2, MSH6, MUTYH, NBN, ATM, PMS2, POLD1, POLE, BARD1, PTEN, RAD51C, RAD51D Specificity 4 % Genes 100 %
Lynch Syndrome Panel. By Genetic Services Laboratory University of Chicago (United States). EPCAM, MLH1, MSH2, MSH6, PMS2, POLD1, POLE Specificity 15 % Genes 100 %
Comprehensive Hereditary Cancer Panel. By Genetic Services Laboratory University of Chicago (United States). RUNX1, BLM, SDHA, SDHB, SDHC, SDHD, BMPR1A, BRCA1, BRCA2, SRP72, STK11, EPCAM, TERC, TERT, TP53, VHL, IKZF1, SAMD9, SAMD9L, CBL , (...) View the complete list with 33 more genes Panel complete gene list RUNX1, BLM, SDHA, SDHB, SDHC, SDHD, BMPR1A, BRCA1, BRCA2, SRP72, STK11, EPCAM, TERC, TERT, TP53, VHL, IKZF1, SAMD9, SAMD9L, CBL, RTEL1, CDH1, CDK4, CDKN2A, CEBPA, DDX41, BRIP1, SDHAF2, TMEM127, PALB2, ANKRD26, ETV6, FH, GATA2, APC, SMAD4, MAX, MEN1, MLH1, MSH2, MSH6, MUTYH, NBN, NF1, ATM, PAX5, PMS2, POLD1, POLE, BAP1, PTEN, PTPN11, RET Specificity 2 % Genes 100 %
Hereditary Melanoma Sequencing Panel. By Genetic Services Laboratory University of Chicago (United States). BRCA1, BRCA2, TP53, WRN, POT1, CDK4, CDKN2A, ACD, MC1R, POLE, BAP1 Specificity 10 % Genes 100 %
Hereditary Colorectal Cancer High Risk Panel. By Genetic Services Laboratory University of Chicago (United States). EPCAM, APC, MLH1, MSH2, MSH6, MUTYH, PMS2, POLD1, POLE Specificity 12 % Genes 100 %
Colorectal Polyposis Panel. By Genetic Services Laboratory University of Chicago (United States). BMPR1A, STK11, BUB1B, GREM1, ENG, APC, SMAD4, MUTYH, AXIN2, POLD1, POLE, PTEN Specificity 9 % Genes 100 %
Comprehensive Hereditary Colorectal Cancer Panel. By Genetic Services Laboratory University of Chicago (United States). BMPR1A, STK11, BUB1B, EPCAM, TP53, CDH1, GALNT12, GREM1, ENG, APC, SMAD4, MLH1, MSH2, MSH6, MUTYH, AXIN2, PMS2, POLD1, POLE, PTEN Specificity 5 % Genes 100 %

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Sources and references

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