ZFP57 gene related symptoms and diseases
All the information presented here about the ZFP57 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,NCBIGENE,OMIM,HGNC, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to ZFP57 gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Failure to thrive | Very Common - Between 80% and 100% cases |
| Transient neonatal diabetes mellitus | Very Common - Between 80% and 100% cases |
| Hyperglycemia | Very Common - Between 80% and 100% cases |
| Intrauterine growth retardation | Very Common - Between 80% and 100% cases |
| Diabetes mellitus | Very Common - Between 80% and 100% cases |
Other less frequent symptoms and clinical features
Patients with ZFP57 gene alterations may also develop some of the following symptoms and phenotypes:Commonly - More than 50% cases
- Dehydration
Not very common - Between 30% and 50% cases
- Intellectual disability
- Growth delay
- Abnormality of the upper urinary tract
- Hypovolemia
- Contractures of the joints of the lower limbs
- Abnormality of the pancreatic islet cells
- Elevated hemoglobin A1c
And 34 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to ZFP57 gene
Here you will find a list of rare diseases related to the ZFP57. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
TRANSIENT NEONATAL DIABETES MELLITUS
Alternate names
TRANSIENT NEONATAL DIABETES MELLITUS Is also known as tndm3, tndm
Description
Transient neonatal diabetes mellitus (TNDM) is a genetically heterogeneous form of neonatal diabetes (NDM, see this term) characterized by hyperglycemia presenting in the neonatal period that remits during infancy but recurs in later life in most patients.
Most common symptoms of TRANSIENT NEONATAL DIABETES MELLITUS
- Intellectual disability
- Seizures
- Global developmental delay
- Hearing impairment
- Failure to thrive
More info about TRANSIENT NEONATAL DIABETES MELLITUS
DIABETES MELLITUS, TRANSIENT NEONATAL, 1
Alternate names
DIABETES MELLITUS, TRANSIENT NEONATAL, 1 Is also known as tndm1, dmtn, tndm
Description
Neonatal diabetes mellitus (NDM), defined as insulin-requiring hyperglycemia within the first month of life, is a rare entity, with an estimated incidence of 1 in 400,000 neonates (Shield, 2000). In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes (OMIM ). In a significant number of patients with transient neonatal diabetes mellitus, type II diabetes appears later in life (Arthur et al., 1997).The major cause of transient neonatal diabetes (TND) is aberrant expression of imprinted genes at chromosome 6q24, associated in 20% of cases with DNA hypomethylation at the TND differentially methylated region (DMR), which lies within the imprinted promoter of the PLAGL1 gene ({603044}; Mackay et al., 2005). Over 50% of individuals with TND and hypomethylation at 6q24 also show mosaic DNA hypomethylation at other imprinted loci throughout the genome and a range of additional clinical features.
Most common symptoms of DIABETES MELLITUS, TRANSIENT NEONATAL, 1
- Growth delay
- Hypertelorism
- Failure to thrive
- Intrauterine growth retardation
- Talipes equinovarus
More info about DIABETES MELLITUS, TRANSIENT NEONATAL, 1
SOURCES: OMIM
Search interest in ZFP57
Potential gene panels for ZFP57 gene
Neonatal Diabetes Mellitus and Maturity-Onset Diabetes of the Young Deletion/Duplication Panel Panel
United States.
By Genetic Services Laboratory University of Chicago Neonatal Diabetes Mellitus and Maturity-Onset Diabetes of the Young Deletion/Duplication Panel that also includes the following genes: BLK SLC2A2 STAT3 KLF11 WFS1 ZBTB20 NEUROG3 LRBA CDKN1C CEL
More info about this panel United States.
Neonatal Diabetes Mellitus and Maturity-Onset Diabetes of the Young Panel Panel
United States.
By Genetic Services Laboratory University of Chicago Neonatal Diabetes Mellitus and Maturity-Onset Diabetes of the Young Panel that also includes the following genes: BLK SLC2A2 STAT3 KLF11 WFS1 ZBTB20 NEUROG3 LRBA CDKN1C CEL
More info about this panel United States.
Comprehensive Neonatal Diabetes Mutation Analysis Panel
United States.
By Genetic Services Laboratory University of Chicago Comprehensive Neonatal Diabetes Mutation Analysis that also includes the following genes: ZFP57 EIF2AK3 GATA4 GATA6 GCK MNX1 HYMAI ABCC8 INS FOXP3
More info about this panel United States.
Neonatal Diabetes Mellitus Deletion/Duplication Analysis Panel
United States.
By Genetic Services Laboratory University of Chicago Neonatal Diabetes Mellitus Deletion/Duplication Analysis that also includes the following genes: ZFP57 EIF2AK3 GCK ABCC8 INS FOXP3 PDX1 KCNJ11
More info about this panel United States.
Neonatal Diabetes Mellitus Sequencing Panel Panel
United States.
By Genetic Services Laboratory University of Chicago Neonatal Diabetes Mellitus Sequencing Panel that also includes the following genes: ZFP57 EIF2AK3 GATA4 GATA6 GCK MNX1 ABCC8 INS FOXP3 PDX1
More info about this panel United States.
ZFP57. Complete sequencing Panel
Spain.
By Instituto de Medicina Genomica Instituto de Medicina Genomica
This panel specifically test the ZFP57 gene.
More info about this panel Spain.
MODY ZFP57 related (sequence analysis of ZFP57 gene) Panel
Portugal.
By CGC Genetics
This panel specifically test the ZFP57 gene.
More info about this panel Portugal.
Transient neonatal diabetes mellitus 1 Panel
Germany.
By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders
This panel specifically test the ZFP57 gene.
More info about this panel Germany.
Neonatal Diabetes Mellitus Panel
Germany.
By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders Neonatal Diabetes Mellitus that also includes the following genes: ZFP57 GCK ABCC8 INS PDX1 KCNJ11
More info about this panel Germany.
MODY panel Panel
Germany.
By Centogene AG - the Rare Disease Company MODY panel that also includes the following genes: BLK HNF1A HNF1B KLF11 CEL ZFP57 RFX6 GCK HNF4A ABCC8
More info about this panel Germany.
Maturity-onset diabetes of the young ZFP57 related Panel
Germany.
By Centogene AG - the Rare Disease Company
This panel specifically test the ZFP57 gene.
More info about this panel Germany.
Maturity Onset Diabetes of the Young (MODY) Panel
Estonia.
By Asper Biogene Asper Biogene LLC Maturity Onset Diabetes of the Young (MODY) that also includes the following genes: BLK HNF1A HNF1B KLF11 CEL ZFP57 RFX6 GCK HNF4A ABCC8
More info about this panel Estonia.
Intellectual Disability NGS Panel Panel
United States.
By Fulgent Genetics Fulgent Genetics Intellectual Disability NGS Panel that also includes the following genes: BCS1L RPS6KA3 SACS BIN1 SCN1A SCN8A SDCCAG8 SGCA SGSH ST3GAL3
More info about this panel United States.
MODY Neonatal Diabetes NGS Panel Panel
United States.
By Fulgent Genetics Fulgent Genetics MODY Neonatal Diabetes NGS Panel that also includes the following genes: BLK SLC2A2 HNF1A HNF1B KLF11 WFS1 NEUROG3 CEL IER3IP1 ZFP57
More info about this panel United States.
ZFP57 Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the ZFP57 gene.
More info about this panel United States.
Comprehensive Monogenic Diabetes Panel Panel
Finland.
By Blueprint Genetics Comprehensive Monogenic Diabetes Panel that also includes the following genes: BLK SLC16A1 SLC2A2 HNF1A HNF1B KLF11 UCP2 WFS1 NEUROG3 ZFP57
More info about this panel Finland.
Diabetes mellitus, transient neonatal, 1 Panel
Spain.
By Bioarray
This panel specifically test the ZFP57 gene.
More info about this panel Spain.
DIABETES MODY & NEONATAL DIABETES : NGS PANEL Panel
Spain.
By Laboratorio de Genetica Clinica SL DIABETES MODY & NEONATAL DIABETES : NGS PANEL that also includes the following genes: BLK SLC2A2 HNF1A HNF1B KLF11 NEUROG3 IER3IP1 ZFP57 RFX6 PTF1A
More info about this panel Spain.
MODY panel Panel
Canada.
By LifeLabs Genetics MODY panel that also includes the following genes: BLK HNF1A HNF1B KLF11 CEL ZFP57 RFX6 GCK HNF4A ABCC8
More info about this panel Canada.
Transient Neonatal Diabetes Mellitus Type 1 , Sequencing ZFP57 Gene Panel
Spain.
By Reference Laboratory Genetics
This panel specifically test the ZFP57 gene.
More info about this panel Spain.
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