WNT10B gene related symptoms and diseases

All the information presented here about the WNT10B gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,ORPHANET,NCBIGENE,HGNC, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to WNT10B gene

Symptoms // Phenotype % Cases
Split hand Uncommon - Between 30% and 50% cases
Oligodontia Uncommon - Between 30% and 50% cases
Microdontia Uncommon - Between 30% and 50% cases
Finger syndactyly Uncommon - Between 30% and 50% cases
Sensorineural hearing impairment Rare - less than 30% cases

Other less frequent symptoms and clinical features

Patients with WNT10B gene alterations may also develop some of the following symptoms and phenotypes:
  • Rarely - Less than 30% cases

  • Sparse hair
  • Abnormality of the face
  • Hypoplasia of the maxilla
  • Micrognathia
  • Selective tooth agenesis
  • Agenesis of permanent teeth
  • Sparse eyebrow
  • Dry skin

And 12 more phenotypes, you can get all of them using our tools for rare diseases.

Rare diseases associated to WNT10B gene

Here you will find a list of rare diseases related to the WNT10B. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


ISOLATED SPLIT HAND-SPLIT FOOT MALFORMATION

Alternate names

ISOLATED SPLIT HAND-SPLIT FOOT MALFORMATION Is also known as shfm, ectrodactyly, split hand foot malformation

Description

Split hand-split foot malformation (SHFM) refers to a spectrum of genetically and clinically heterogenous terminal limb defect (see this term) characterized by hypoplasia/ absence of central rays of the hands and feet (that can occur in one to all four digits), median clefts of the hands and/ or feet, aplasia and syndactyly, with a wide range of severity ranging from malformed central finger/ toe to a lobster claw-like appearance of the hands and feet. SHFM can be an isolated malformation or can be a feature in various syndromes (ADULT syndrome, EEC syndrome; see these terms). SHFM usually follows an autosomal dominant pattern of inheritance with incomplete penetrance, but autosomal recessive and rarely X-linked inheritance have also been reported.

Most common symptoms of ISOLATED SPLIT HAND-SPLIT FOOT MALFORMATION

  • Sensorineural hearing impairment
  • Finger syndactyly
  • Split hand
  • Oligodactyly
  • Aniridia


More info about ISOLATED SPLIT HAND-SPLIT FOOT MALFORMATION

SOURCES: ORPHANET

SPLIT-HAND/FOOT MALFORMATION 6; SHFM6

Alternate names

SPLIT-HAND/FOOT MALFORMATION 6; SHFM6 Is also known as ectrodactyly, autosomal recessive

Description

Split-hand/split-foot malformation (SHFM) is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients with SHFM have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting (Elliott and Evans, 2006).For a general phenotypic description and a discussion of genetic heterogeneity of split-hand/foot malformations, see SHFM1 (OMIM ).

Most common symptoms of SPLIT-HAND/FOOT MALFORMATION 6; SHFM6

  • Intellectual disability
  • Syndactyly
  • Finger syndactyly
  • Toe syndactyly
  • Split hand


More info about SPLIT-HAND/FOOT MALFORMATION 6; SHFM6

SOURCES: OMIM

TOOTH AGENESIS, SELECTIVE, 8; STHAG8

Most common symptoms of TOOTH AGENESIS, SELECTIVE, 8; STHAG8

  • Sparse hair
  • Dry skin
  • Microdontia
  • Oligodontia
  • Sparse eyebrow


More info about TOOTH AGENESIS, SELECTIVE, 8; STHAG8

SOURCES: OMIM

OLIGODONTIA

Alternate names

OLIGODONTIA Is also known as selective tooth agenesis

Description

Oligodontia is a rare developmental dental anomaly in humans characterized by the absence of six or more teeth.

Most common symptoms of OLIGODONTIA

  • Micrognathia
  • Hypoplasia of the maxilla
  • Microdontia
  • Abnormality of the face
  • Oligodontia


More info about OLIGODONTIA

SOURCES: ORPHANET


Potential gene panels for WNT10B gene

Split-hand/foot malformation 6 (sequence analysis of WNT10B gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the WNT10B gene.

More info about this panel
Portugal.

Oligodontia - Selective tooth agenesis Comprehensive panel Panel

United States.

By Connective Tissue Gene Tests Oligodontia - Selective tooth agenesis Comprehensive panel that also includes the following genes: WNT10B WNT10A EDA LRP6 LTBP3 MSX1 PAX9 AXIN2 PTH1R

More info about this panel
United States.

Oligodontia - Selective tooth agenesis NGS panel Panel

United States.

By Connective Tissue Gene Tests Oligodontia - Selective tooth agenesis NGS panel that also includes the following genes: WNT10B WNT10A EDA LRP6 LTBP3 MSX1 PAX9 AXIN2 PTH1R

More info about this panel
United States.

Oligodontia - Selective tooth agenesis Deletion / Duplication panel Panel

United States.

By Connective Tissue Gene Tests Oligodontia - Selective tooth agenesis Deletion / Duplication panel that also includes the following genes: WNT10B WNT10A EDA LRP6 LTBP3 MSX1 PAX9 AXIN2 PTH1R

More info about this panel
United States.

Split-hand/foot malformation type 6 Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the WNT10B gene.

More info about this panel
Germany.

Isolated limb hypoplasia and limb reduction defects: Split-hand/foot; Synostosis; isolated Brachydactyly; Polydactyly; Syndactyly Panel Panel

Germany.

By CeGaT GmbH Isolated limb hypoplasia and limb reduction defects: Split-hand/foot; Synostosis; isolated Brachydactyly; Polydactyly; Syndactyly Panel that also includes the following genes: ROR2 BMP2 BMPR1B WNT10B WNT7A LMBR1 TP63 TRPV4 BHLHA9 FBLN1

More info about this panel
Germany.

WNT10B Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the WNT10B gene.

More info about this panel
United States.

SPLIT HAND-SPLIT FOOT MALFORMATION Panel

Spain.

By Laboratorio de Genetica Clinica SL SPLIT HAND-SPLIT FOOT MALFORMATION that also includes the following genes: SEM1 WNT10B TP63 DLX5

More info about this panel
Spain.

Ectrodactyly and Related Disorders , Panel Massive Sequencing (NGS) 4 Genes Panel

Spain.

By Reference Laboratory Genetics Ectrodactyly and Related Disorders , Panel Massive Sequencing (NGS) 4 Genes that also includes the following genes: WNT10B WNT3 LMBR1 TP63

More info about this panel
Spain.

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel
United States.

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