1. Mendelian
  2. Rare Disease Genes
  3. TRPM7

TRPM7 gene related symptoms and diseases

All the information presented here about the TRPM7 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: HGNC,ORPHANET,NCBIGENE,OMIM, Mendelian Rare Disease Search Engine.

Table of contents:

Top 5 symptoms and clinical features associated to TRPM7 gene

Symptoms // Phenotype % Cases
Muscle weakness Very Common - Between 80% and 100% cases
Dementia Very Common - Between 80% and 100% cases
Paralysis Very Common - Between 80% and 100% cases
Muscle cramps Very Common - Between 80% and 100% cases
Parkinsonism Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with TRPM7 gene alterations may also develop some of the following symptoms and phenotypes:

  • Commonly - More than 50% cases

  • Amyotrophic lateral sclerosis
  • Bulbar palsy
  • Abnormal lower motor neuron morphology

Rare diseases associated to TRPM7 gene

Here you will find a list of rare diseases related to the TRPM7. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


AMYOTROPHIC LATERAL SCLEROSIS-PARKINSONISM-DEMENTIA COMPLEX

Alternate names

AMYOTROPHIC LATERAL SCLEROSIS-PARKINSONISM-DEMENTIA COMPLEX Is also known as guam disease, als-pdc, parkinsonism-dementia-als complex, pdals, amyotrophic lateral sclerosis-parkinsonism-dementia of guam syndrome, amyotrophic lateral sclerosis-parkinsonism/dementia complex of guam, lytico-bodig disease

Description

Amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam is a neurodegenerative disorder with unusually high incidence among the Chamorro people of Guam. Both ALS and parkinsonism-dementia are chronic, progressive, and uniformly fatal disorders in this population. Both diseases are known to occur in the same kindred, the same sibship, and even the same individual.

Most common symptoms of AMYOTROPHIC LATERAL SCLEROSIS-PARKINSONISM-DEMENTIA COMPLEX

  • Muscle weakness
  • Dementia
  • Paralysis
  • Muscle cramps
  • Parkinsonism


More info about AMYOTROPHIC LATERAL SCLEROSIS-PARKINSONISM-DEMENTIA COMPLEX

SOURCES: OMIM ORPHANET


Potential gene panels for TRPM7 gene

Hereditary dementias (NGS panel for 28 genes) Panel

Portugal.

By CGC Genetics Hereditary dementias (NGS panel for 28 genes) that also includes the following genes: SNCA SNCB SORL1 TARDBP TIMM8A TUBA4A TYROBP UBQLN2 VCP CHCHD10

More info about this panel
Portugal.

Amyotrophic lateral sclerosis-parkinsonism/dementia complex, susceptibility to Panel

Germany.

By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders

This panel specifically test the TRPM7 gene.

More info about this panel
Germany.

AllNeuro panel Panel

Germany.

By Centogene AG - the Rare Disease Company AllNeuro panel that also includes the following genes: BCS1L ROR2 RPL10 BDNF RPS6KA3 RTN2 RYR1 SACS BIN1 SBF1

More info about this panel
Germany.

TRPM7 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the TRPM7 gene.

More info about this panel
United States.

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