TNF gene related symptoms and diseases
All the information presented here about the TNF gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,HGNC,OMIM, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to TNF gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Anemia | Common - Between 50% and 80% cases |
| Fever | Common - Between 50% and 80% cases |
| Respiratory distress | Common - Between 50% and 80% cases |
| Intellectual disability | Uncommon - Between 30% and 50% cases |
| Abnormality of the nervous system | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with TNF gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Thrombocytopenia
- Abnormality of blood and blood-forming tissues
- Wheezing
- Bone pain
- Cholestasis
- Hemolytic anemia
- Hepatic failure
- Confusion
And 173 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to TNF gene
Here you will find a list of rare diseases related to the TNF. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
SICKLE CELL ANEMIA
Alternate names
SICKLE CELL ANEMIA Is also known as sickle cell disease
Description
Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.
Most common symptoms of SICKLE CELL ANEMIA
- Intellectual disability
- Pain
- Anemia
- Hypertension
- Hepatomegaly
More info about SICKLE CELL ANEMIA
ORAL SUBMUCOUS FIBROSIS
Alternate names
ORAL SUBMUCOUS FIBROSIS Is also known as osmf
Description
Oral submucous fibrosis (OSMF) is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in India and Southeast Asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro-pharynx (leading to trismus and a progressive reduction in mouth opening) and an increased risk of developing oral squamous cell cancer (3-19%). It is usually associated with the chewing of the areca nut (an ingredient in betel quid) but the exact etiology is unknown and there is currently no effective treatment.
Most common symptoms of ORAL SUBMUCOUS FIBROSIS
- Flexion contracture
- Narrow mouth
- Trismus
- Cheilitis
- Abnormality of the pharynx
More info about ORAL SUBMUCOUS FIBROSIS
WILSON DISEASE
Alternate names
WILSON DISEASE Is also known as wd, hepatolenticular degeneration, wnd
Description
Wilson disease is a very rare inherited multisystemic disease presenting non-specific neurological, hepatic, psychiatric or osseo-muscular manifestations due to excessive copper deposition in the body.
Most common symptoms of WILSON DISEASE
- Intellectual disability
- Growth delay
- Neoplasm
- Failure to thrive
- Spasticity
More info about WILSON DISEASE
ASTHMA, SUSCEPTIBILITY TO
Alternate names
ASTHMA, SUSCEPTIBILITY TO Is also known as asthma, bronchial, asthma-related traits, susceptibility to
Description
Bronchial asthma is the most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment.Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002; Pillai et al., 2006). See {147050} for information on the asthma-associated phenotype atopy.
Most common symptoms of ASTHMA, SUSCEPTIBILITY TO
- Fever
- Respiratory distress
- Dyspnea
- Cough
- Asthma
More info about ASTHMA, SUSCEPTIBILITY TO
SOURCES: OMIM
MALARIA
Description
Malaria is a preventable life-threatening parasitic disease caused by Plasmodium (P. ) parasites that are transmitted by Anophles mosquito bites to humans and is typically clinically characterized by attacks of fever, headache, chills and vomiting.
Most common symptoms of MALARIA
- Cognitive impairment
- Anemia
- Fever
- Respiratory distress
- Headache
More info about MALARIA
Search interest in TNF
Potential gene panels for TNF gene
AllNeuro panel Panel
Germany.
By Centogene AG - the Rare Disease Company AllNeuro panel that also includes the following genes: BCS1L ROR2 RPL10 BDNF RPS6KA3 RTN2 RYR1 SACS BIN1 SBF1
More info about this panel Germany.
TNF Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the TNF gene.
More info about this panel United States.
Immune Report Card Panel
United States.
By OmniSeq, Inc. Immune Report Card that also includes the following genes: CXCL10 STAT1 TBX21 TGFB1 TNF TNFRSF14 TNFRSF18 CD40 CD27 TNFRSF9
More info about this panel United States.
Asthma Susceptibility to, Sequencing TNF Gene Panel
Spain.
By Reference Laboratory Genetics
This panel specifically test the TNF gene.
More info about this panel Spain.
Asthma Susceptibility to, Panel Massive Sequencing (NGS) 10 Genes Panel
Spain.
By Reference Laboratory Genetics Asthma Susceptibility to, Panel Massive Sequencing (NGS) 10 Genes that also includes the following genes: CCL11 TNF SCGB3A2 ALOX5 HLA-G HNMT IL13 MUC7 PLA2G7
More info about this panel Spain.
Tempus xT assay Panel
United States.
By Tempus Labs, Inc. Tempus xT assay that also includes the following genes: BCL6 RIT1 BCL7A BCR ROS1 RPL5 RPS15 RPS6KB1 RUNX1 RXRA
More info about this panel United States.
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