TLR3 gene related symptoms and diseases

All the information presented here about the TLR3 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,ORPHANET,HGNC,OMIM, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to TLR3 gene

Symptoms // Phenotype % Cases
Encephalitis Common - Between 50% and 80% cases
Herpes simplex encephalitis Common - Between 50% and 80% cases
Encephalopathy Common - Between 50% and 80% cases
Immunodeficiency Uncommon - Between 30% and 50% cases
Confusion Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with TLR3 gene alterations may also develop some of the following symptoms and phenotypes:
  • Not very common - Between 30% and 50% cases

  • Homonymous hemianopia
  • CNS infection
  • Encephalomalacia
  • Hemianopia
  • Meningitis
  • Hemiparesis
  • Gliosis
  • EEG abnormality

And 10 more phenotypes, you can get all of them using our tools for rare diseases.

Rare diseases associated to TLR3 gene

Here you will find a list of rare diseases related to the TLR3. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


HERPES SIMPLEX VIRUS ENCEPHALITIS

Alternate names

HERPES SIMPLEX VIRUS ENCEPHALITIS Is also known as herpetic encephalitis, herpes simplex meningo-encephalitis, hsv encephalitis, herpes simplex encephalitis, susceptibility to, 1, hsve, herpes simplex neuroinvasion, hse

Description

Herpes simplex virus encephalitis (HSVE) is caused by the infection of the central nervous system by Herpes simplex virus (HSV) that could have a devastating clinical course and a potentially fatal outcome particularly with delay or lack of treatment. HSVE often involves the frontal and temporal lobes, usually asymmetrically, resulting in personality changes, cognitive impairment, aphasia, seizures, and focal weakness.

Most common symptoms of HERPES SIMPLEX VIRUS ENCEPHALITIS

  • Immunodeficiency
  • Encephalopathy
  • Encephalitis
  • Herpes simplex encephalitis
  • Susceptibility to herpesvirus


More info about HERPES SIMPLEX VIRUS ENCEPHALITIS

SOURCES: OMIM ORPHANET

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO

Alternate names

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO Is also known as hiv-1, susceptibility to

Description

The pathogenesis of HIV infection and the progression from infection to AIDS vary significantly between exposed individuals. Infection occurs after the virus, which has macrophage (M)- and T lymphocyte (T)-tropic strains and more than 12 subtypes, survives an array of nonspecific, nongenetic environmental and host factors.


More info about HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO

SOURCES: OMIM

ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 2; IIAE2

Alternate names

ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 2; IIAE2 Is also known as herpes simplex encephalitis, susceptibility to, 2

Description

Herpes simplex encephalitis (HSE) is a severe viral infection of the central nervous system (CNS) resulting most commonly from infection with HSV-1 and occasionally by HSV-2. The disease peaks in childhood between 3 months and 3 years of age, although later onset can also occur, and affected individuals usually have neurologic sequelae, including seizures and cognitive or motor impairment. Some individuals may have recurrences of an acute episode of HSE; however, patients have no clear susceptibility to infection to other viruses. The virus gains entry to the CNS through a neuronal route via the trigeminal or olfactory nerves, not via the blood. Replication of this enveloped double-stranded DNA (dsDNA) virus involves the production and accumulation of RNA species, including dsRNA, which are recognized by the intracellular TLR3 signaling pathway. The susceptibility to HSV in particular appears to result from impaired TLR3-dependent interferon production by nonhematopoietic cells that reside within the CNS (review by Zhang et al., 2013; summary by Mork et al., 2015).For a general phenotypic description of herpes simplex encephalitis and a discussion of genetic heterogeneity of acute infection-induced encephalopathy, see {610551}.

Most common symptoms of ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 2; IIAE2

  • Intellectual disability
  • Seizures
  • Cognitive impairment
  • Fever
  • Vomiting


More info about ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 2; IIAE2

SOURCES: OMIM


Potential gene panels for TLR3 gene

MitoMet®Plus aCGH Analysis Panel

United States.

By Baylor Miraca Genetics Laboratories MitoMet®Plus aCGH Analysis that also includes the following genes: RGS9 RHO GRK1 RLBP1 RNASEL BCS1L RP1 RP2 RP9 RPE65

More info about this panel
United States.

TLR3 Deletion/duplication analysis Panel

United States.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center

This panel specifically test the TLR3 gene.

More info about this panel
United States.

TLR3 Sequencing Panel

United States.

By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center

This panel specifically test the TLR3 gene.

More info about this panel
United States.

Candidiasis (CMC) panel Panel

Netherlands.

By Genome Diagnostics Laboratory University Medical Center Utrecht Candidiasis (CMC) panel that also includes the following genes: STAT1 TLR3 IL17F AIRE IL17RA IL2RA

More info about this panel
Netherlands.

Herpes simplex encephalitis type 2, susceptibility to Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the TLR3 gene.

More info about this panel
Germany.

AllNeuro panel Panel

Germany.

By Centogene AG - the Rare Disease Company AllNeuro panel that also includes the following genes: BCS1L ROR2 RPL10 BDNF RPS6KA3 RTN2 RYR1 SACS BIN1 SBF1

More info about this panel
Germany.

Defects in innate immunity Panel Panel

Germany.

By CeGaT GmbH Defects in innate immunity Panel that also includes the following genes: STAT1 TBK1 TLR3 TRAF3 TRAF3IP2 UNC93B1 CARD9 IL17F TIRAP IRAK4

More info about this panel
Germany.

Invitae Primary Immunodeficiency Panel Panel

United States.

By Invitae Invitae Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC SEMA3E SH2D1A SH3BP2 SLC7A7 SMARCAL1 BTK STAT1 STAT2

More info about this panel
United States.

Invitae Herpes Simplex Encephalitis Panel Panel

United States.

By Invitae Invitae Herpes Simplex Encephalitis Panel that also includes the following genes: TBK1 TLR3 TRAF3 UNC93B1 TICAM1

More info about this panel
United States.

TLR3 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the TLR3 gene.

More info about this panel
United States.

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