TLR3 gene related symptoms and diseases
All the information presented here about the TLR3 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,ORPHANET,HGNC,OMIM, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to TLR3 gene
Symptoms // Phenotype | % Cases |
---|---|
Encephalitis | Common - Between 50% and 80% cases |
Herpes simplex encephalitis | Common - Between 50% and 80% cases |
Encephalopathy | Common - Between 50% and 80% cases |
Immunodeficiency | Uncommon - Between 30% and 50% cases |
Confusion | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with TLR3 gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Homonymous hemianopia
- CNS infection
- Encephalomalacia
- Hemianopia
- Meningitis
- Hemiparesis
- Gliosis
- EEG abnormality
And 10 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to TLR3 gene
Here you will find a list of rare diseases related to the TLR3. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
HERPES SIMPLEX VIRUS ENCEPHALITIS
Alternate names
HERPES SIMPLEX VIRUS ENCEPHALITIS Is also known as herpetic encephalitis, herpes simplex meningo-encephalitis, hsv encephalitis, herpes simplex encephalitis, susceptibility to, 1, hsve, herpes simplex neuroinvasion, hse
Description
Herpes simplex virus encephalitis (HSVE) is caused by the infection of the central nervous system by Herpes simplex virus (HSV) that could have a devastating clinical course and a potentially fatal outcome particularly with delay or lack of treatment. HSVE often involves the frontal and temporal lobes, usually asymmetrically, resulting in personality changes, cognitive impairment, aphasia, seizures, and focal weakness.
Most common symptoms of HERPES SIMPLEX VIRUS ENCEPHALITIS
- Immunodeficiency
- Encephalopathy
- Encephalitis
- Herpes simplex encephalitis
- Susceptibility to herpesvirus
More info about HERPES SIMPLEX VIRUS ENCEPHALITIS
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
Alternate names
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO Is also known as hiv-1, susceptibility to
Description
The pathogenesis of HIV infection and the progression from infection to AIDS vary significantly between exposed individuals. Infection occurs after the virus, which has macrophage (M)- and T lymphocyte (T)-tropic strains and more than 12 subtypes, survives an array of nonspecific, nongenetic environmental and host factors.
More info about HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
SOURCES: OMIM
ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 2; IIAE2
Alternate names
ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 2; IIAE2 Is also known as herpes simplex encephalitis, susceptibility to, 2
Description
Herpes simplex encephalitis (HSE) is a severe viral infection of the central nervous system (CNS) resulting most commonly from infection with HSV-1 and occasionally by HSV-2. The disease peaks in childhood between 3 months and 3 years of age, although later onset can also occur, and affected individuals usually have neurologic sequelae, including seizures and cognitive or motor impairment. Some individuals may have recurrences of an acute episode of HSE; however, patients have no clear susceptibility to infection to other viruses. The virus gains entry to the CNS through a neuronal route via the trigeminal or olfactory nerves, not via the blood. Replication of this enveloped double-stranded DNA (dsDNA) virus involves the production and accumulation of RNA species, including dsRNA, which are recognized by the intracellular TLR3 signaling pathway. The susceptibility to HSV in particular appears to result from impaired TLR3-dependent interferon production by nonhematopoietic cells that reside within the CNS (review by Zhang et al., 2013; summary by Mork et al., 2015).For a general phenotypic description of herpes simplex encephalitis and a discussion of genetic heterogeneity of acute infection-induced encephalopathy, see {610551}.
Most common symptoms of ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 2; IIAE2
- Intellectual disability
- Seizures
- Cognitive impairment
- Fever
- Vomiting
More info about ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 2; IIAE2
SOURCES: OMIM
Search interest in TLR3
Potential gene panels for TLR3 gene
MitoMet®Plus aCGH Analysis Panel
By Baylor Miraca Genetics Laboratories MitoMet®Plus aCGH Analysis that also includes the following genes: RGS9 RHO GRK1 RLBP1 RNASEL BCS1L RP1 RP2 RP9 RPE65
More info about this panelTLR3 Deletion/duplication analysis Panel
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center
This panel specifically test the TLR3 gene.
More info about this panelTLR3 Sequencing Panel
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center
This panel specifically test the TLR3 gene.
More info about this panelCandidiasis (CMC) panel Panel
By Genome Diagnostics Laboratory University Medical Center Utrecht Candidiasis (CMC) panel that also includes the following genes: STAT1 TLR3 IL17F AIRE IL17RA IL2RA
More info about this panelHerpes simplex encephalitis type 2, susceptibility to Panel
By Centogene AG - the Rare Disease Company
This panel specifically test the TLR3 gene.
More info about this panelAllNeuro panel Panel
By Centogene AG - the Rare Disease Company AllNeuro panel that also includes the following genes: BCS1L ROR2 RPL10 BDNF RPS6KA3 RTN2 RYR1 SACS BIN1 SBF1
More info about this panelDefects in innate immunity Panel Panel
By CeGaT GmbH Defects in innate immunity Panel that also includes the following genes: STAT1 TBK1 TLR3 TRAF3 TRAF3IP2 UNC93B1 CARD9 IL17F TIRAP IRAK4
More info about this panelInvitae Primary Immunodeficiency Panel Panel
By Invitae Invitae Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC SEMA3E SH2D1A SH3BP2 SLC7A7 SMARCAL1 BTK STAT1 STAT2
More info about this panelInvitae Herpes Simplex Encephalitis Panel Panel
By Invitae Invitae Herpes Simplex Encephalitis Panel that also includes the following genes: TBK1 TLR3 TRAF3 UNC93B1 TICAM1
More info about this panelTLR3 Panel
By Fulgent Genetics Fulgent Genetics
This panel specifically test the TLR3 gene.
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