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  1. Mendelian
  2. Rare Disease Genes
  3. TLR2

TLR2 gene related symptoms and diseases

All the information presented here about the TLR2 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,HGNC,OMIM, Mendelian Rare Disease Search Engine.

Table of contents:

Top 5 symptoms and clinical features associated to TLR2 gene

Symptoms // Phenotype % Cases
Pain Uncommon - Between 30% and 50% cases
Colitis Uncommon - Between 30% and 50% cases
Uterine leiomyosarcoma Uncommon - Between 30% and 50% cases
Neoplasm of the stomach Uncommon - Between 30% and 50% cases
Hereditary nonpolyposis colorectal carcinoma Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with TLR2 gene alterations may also develop some of the following symptoms and phenotypes:

  • Not very common - Between 30% and 50% cases

  • Transitional cell carcinoma of the bladder
  • Colorectal polyposis
  • Endometrial carcinoma
  • Leiomyosarcoma
  • Retinoblastoma
  • Ulcerative colitis
  • Renal cell carcinoma
  • Colon cancer

And 12 more phenotypes, you can get all of them using our tools for rare diseases.

Rare diseases associated to TLR2 gene

Here you will find a list of rare diseases related to the TLR2. You can also use our tool to get a more accurate diagnosis based on your current symptoms.

MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO

Description

Mycobacterium tuberculosis latently infects approximately one-third of humanity and is comparable only to human immunodeficiency virus (HIV; see {609423}) as a leading infectious cause of mortality worldwide. Obstacles for controlling TB infection include lengthy treatment regimens of 6 to 9 months, drug resistance, lack of a highly efficacious vaccine, and incomplete understanding of the factors that control infectivity and disease progression. Although only 10% of individuals infected with M. tuberculosis develop active disease, the immune responses associated with TB susceptibility or resistance are not known. In addition, it is not known why some individuals have disseminated TB that spreads to the meninges and central nervous system, while most people have localized disease in the lungs. A number of studies suggest that host genetic factors influence susceptibility and resistance to TB (review by Berrington and Hawn, 2007).

Most common symptoms of MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO

  • Pain
  • Fever
  • Fatigue
  • Immunodeficiency
  • Weight loss
More info about MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO

SOURCES: OMIM MESH

COLORECTAL CANCER; CRC

Alternate names

COLORECTAL CANCER; CRC Is also known as colon cancer

Description

Colorectal cancer is a heterogeneous disease that is common in both men and women. In addition to lifestyle and environmental risk factors, gene defects can contribute to an inherited predisposition to CRC. CRC is caused by changes in different molecular pathogenic pathways, such as chromosomal instability, CpG island methylator phenotype, and microsatellite instability. Chromosome instability is the most common alteration and is present in almost 85% of all cases (review by Schweiger et al., 2013).

Most common symptoms of COLORECTAL CANCER; CRC

  • Neoplasm
  • Carcinoma
  • Oligodontia
  • Colon cancer
  • Colitis
More info about COLORECTAL CANCER; CRC

SOURCES: OMIM

LEPROSY, SUSCEPTIBILITY TO, 3; LPRS3

Most common symptoms of LEPROSY, SUSCEPTIBILITY TO, 3; LPRS3

  • Abnormality of the immune system
More info about LEPROSY, SUSCEPTIBILITY TO, 3; LPRS3

SOURCES: OMIM

Potential gene panels for TLR2 gene

TLR2 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the TLR2 gene.

More info about this panel
United States.

Focus::MCL™ NGS Panel Panel

United States.

By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::MCL™ NGS Panel that also includes the following genes: SALL3 SI SMARCA4 BTK TLR2 TP53 TRAF2 NSD2 XPO1 KMT2C

More info about this panel
United States.

Tempus xO assay Panel

United States.

By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2

More info about this panel
United States.

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