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TIRAP gene related symptoms and diseases

All the information presented here about the TIRAP gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,HGNC,OMIM, Mendelian Rare Disease Search Engine.

Table of contents:

Top 5 symptoms and clinical features associated to TIRAP gene

Symptoms // Phenotype % Cases
Headache Uncommon - Between 30% and 50% cases
Fever Uncommon - Between 30% and 50% cases
Pain Rare - less than 30% cases
Respiratory distress Rare - less than 30% cases
Elevated C-reactive protein level Rare - less than 30% cases

Other less frequent symptoms and clinical features

Patients with TIRAP gene alterations may also develop some of the following symptoms and phenotypes:

  • Rarely - Less than 30% cases

  • Gait imbalance
  • Reduced consciousness/confusion
  • Acute kidney injury
  • Abnormality of blood and blood-forming tissues
  • Hyperbilirubinemia
  • Nausea and vomiting
  • Retinopathy
  • Myalgia

And 14 more phenotypes, you can get all of them using our tools for rare diseases.

Rare diseases associated to TIRAP gene

Here you will find a list of rare diseases related to the TIRAP. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO

Description

Mycobacterium tuberculosis latently infects approximately one-third of humanity and is comparable only to human immunodeficiency virus (HIV; see {609423}) as a leading infectious cause of mortality worldwide. Obstacles for controlling TB infection include lengthy treatment regimens of 6 to 9 months, drug resistance, lack of a highly efficacious vaccine, and incomplete understanding of the factors that control infectivity and disease progression. Although only 10% of individuals infected with M. tuberculosis develop active disease, the immune responses associated with TB susceptibility or resistance are not known. In addition, it is not known why some individuals have disseminated TB that spreads to the meninges and central nervous system, while most people have localized disease in the lungs. A number of studies suggest that host genetic factors influence susceptibility and resistance to TB (review by Berrington and Hawn, 2007).

Most common symptoms of MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO

  • Pain
  • Fever
  • Fatigue
  • Immunodeficiency
  • Weight loss


More info about MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO

SOURCES: OMIM MESH

INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED, 1; IPD1

Description

Recurrent invasive pneumococcal disease (IPD) is defined as 2 episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains (Ku et al., 2007). Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD.

Most common symptoms of INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED, 1; IPD1

  • Headache
  • Arthritis
  • Meningitis
  • Recurrent streptococcus pneumoniae infections


More info about INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED, 1; IPD1

SOURCES: MESH OMIM

BACTEREMIA, SUSCEPTIBILITY TO, 1; BACTS1


More info about BACTEREMIA, SUSCEPTIBILITY TO, 1; BACTS1

SOURCES: OMIM

MALARIA

Description

Malaria is a preventable life-threatening parasitic disease caused by Plasmodium (P. ) parasites that are transmitted by Anophles mosquito bites to humans and is typically clinically characterized by attacks of fever, headache, chills and vomiting.

Most common symptoms of MALARIA

  • Cognitive impairment
  • Anemia
  • Fever
  • Respiratory distress
  • Headache


More info about MALARIA

SOURCES: OMIM ORPHANET


Potential gene panels for TIRAP gene

AllNeuro panel Panel

Germany.

By Centogene AG - the Rare Disease Company AllNeuro panel that also includes the following genes: BCS1L ROR2 RPL10 BDNF RPS6KA3 RTN2 RYR1 SACS BIN1 SBF1

More info about this panel
Germany.

Defects in innate immunity Panel Panel

Germany.

By CeGaT GmbH Defects in innate immunity Panel that also includes the following genes: STAT1 TBK1 TLR3 TRAF3 TRAF3IP2 UNC93B1 CARD9 IL17F TIRAP IRAK4

More info about this panel
Germany.

TIRAP Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the TIRAP gene.

More info about this panel
United States.

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