TET2 gene related symptoms and diseases
All the information presented here about the TET2 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: HGNC,OMIM,ORPHANET,NCBIGENE, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to TET2 gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Splenomegaly | Uncommon - Between 30% and 50% cases |
| Hepatosplenomegaly | Uncommon - Between 30% and 50% cases |
| Leukemia | Uncommon - Between 30% and 50% cases |
| Myelofibrosis | Uncommon - Between 30% and 50% cases |
| Hepatomegaly | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with TET2 gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Fatigue
- Myeloproliferative disorder
- Headache
- Myelodysplasia
Rarely - Less than 30% cases
- Neoplasm
- Increased megakaryocyte count
- Leukocytosis
- Chest pain
And 107 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to TET2 gene
Here you will find a list of rare diseases related to the TET2. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
POLYCYTHEMIA VERA
Alternate names
POLYCYTHEMIA VERA Is also known as polycythemia rubra vera, acquired primary erythrocytosis, prv, vaquez disease, osler-vaquez disease, pv
Description
Polycythemia vera (PV) is an acquired myeloproliferative disorder characterized by an elevated absolute red blood cell mass caused by uncontrolled red blood cell production, frequently associated with uncontrolled white blood cell and platelet production.
Most common symptoms of POLYCYTHEMIA VERA
- Neoplasm
- Visual impairment
- Hypertension
- Hepatomegaly
- Fatigue
More info about POLYCYTHEMIA VERA
ACUTE PROMYELOCYTIC LEUKEMIA
Alternate names
ACUTE PROMYELOCYTIC LEUKEMIA Is also known as acute myeloid leukemia with t(15;17)(q22;q12);(pml/raralpha) and variants, acute myeloblastic leukemia 3, apml, aml m3, aml with t(15;17)(q22;q12);(pml/raralpha) and variants, leukemia, acute promyelocytic
Description
Acute promyelocytic leukemia (APL) is an aggressive form of acute myeloid leukemia (AML; see this term), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells. APL manifests with easy bruising, hemorrhagic diathesis and fatigue.
Most common symptoms of ACUTE PROMYELOCYTIC LEUKEMIA
- Leukemia
- Acute promyelocytic leukemia
- Abnormal granulocytopoietic cell morphology
More info about ACUTE PROMYELOCYTIC LEUKEMIA
SÉZARY SYNDROME
Alternate names
SÉZARY SYNDROME Is also known as sÉzary lymphoma
Description
Sézary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma characterized by a triad of erythroderma, lymphadenopathy and circulating atypical lymphocytes (Sézary cells).
Most common symptoms of SÉZARY SYNDROME
- Neoplasm
- Abnormal facial shape
- Peripheral neuropathy
- Hepatomegaly
- Fever
More info about SÉZARY SYNDROME
REFRACTORY ANEMIA
Description
Refractory cytopenias with unilineage dysplasia (RCUD) is a frequent low-risk subtype of myelodysplastic syndrome (MDS; see this term) characterized by refractory cytopenias associated with dysplasia limited to one cell lineage.
More info about REFRACTORY ANEMIA
SOURCES: ORPHANET
ESSENTIAL THROMBOCYTHEMIA
Alternate names
ESSENTIAL THROMBOCYTHEMIA Is also known as thrombocytosis 1, essential thrombocytosis, et
Description
Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN, see this term) characterized by a sustained elevation of platelet number (> 450 x 109/L) with a tendency for thrombosis and hemorrhage.
Most common symptoms of ESSENTIAL THROMBOCYTHEMIA
- Pain
- Hypertension
- Hepatomegaly
- Abnormality of the skeletal system
- Respiratory distress
More info about ESSENTIAL THROMBOCYTHEMIA
MYELODYSPLASTIC SYNDROME; MDS
Alternate names
MYELODYSPLASTIC SYNDROME; MDS Is also known as myelodysplastic syndrome, susceptibility to, included
Description
Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematologic stem cell disorders characterized by ineffective hematopoiesis resulting in low blood counts, most commonly anemia, and a risk of progression to acute myeloid leukemia (AML ). Blood smears and bone marrow biopsies show dysplastic changes in myeloid cells, with abnormal proliferation and differentiation of 1 or more lineages (erythroid, myeloid, megakaryocytic). MDS can be subdivided into several categories based on morphologic characteristics, such as low-grade refractory anemia (RA) or high-grade refractory anemia with excess blasts (RAEB). Bone marrow biopsies of some patients show ringed sideroblasts (RARS), which reflects abnormal iron staining in mitochondria surrounding the nucleus of erythrocyte progenitors (summary by Delhommeau et al., 2009 and Papaemmanuil et al., 2011).
Most common symptoms of MYELODYSPLASTIC SYNDROME; MDS
- Anemia
- Leukemia
- Myelodysplasia
- Myeloid leukemia
- Acute myeloid leukemia
More info about MYELODYSPLASTIC SYNDROME; MDS
ACQUIRED IDIOPATHIC SIDEROBLASTIC ANEMIA
Alternate names
ACQUIRED IDIOPATHIC SIDEROBLASTIC ANEMIA Is also known as rars, primary acquired sideroblastic anemia, refractory anemia with ringed sideroblasts, aisa
Description
Acquired idiopathic sideroblastic anaemia is one of a group of disorders known as the myelodysplastic syndromes (MDS) characterised by ineffective haemopoiesis affecting one or more blood cell lineages (myeloid, erythroid or megakaryocytic) leading to peripheral blood cytopenias and an increased risk of developing leukaemia. Acquired idiopathic sideroblastic anaemia is now more commonly referred to as refractory anaemia with ringed sideroblasts or the acronym RARS.
Most common symptoms of ACQUIRED IDIOPATHIC SIDEROBLASTIC ANEMIA
- Pain
- Anemia
- Fatigue
- Respiratory distress
- Congestive heart failure
More info about ACQUIRED IDIOPATHIC SIDEROBLASTIC ANEMIA
PRIMARY MYELOFIBROSIS
Alternate names
PRIMARY MYELOFIBROSIS Is also known as myelofibrosis with myeloid metaplasia, idiopathic myelofibrosis, agnogenic myeloid metaplasia, osteomyelofibrosis
Description
Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension.
Most common symptoms of PRIMARY MYELOFIBROSIS
- Fever
- Fatigue
- Splenomegaly
- Hepatosplenomegaly
- Pallor
More info about PRIMARY MYELOFIBROSIS
ACUTE MYELOID LEUKAEMIA WITH MYELODYSPLASIA-RELATED FEATURES
Alternate names
ACUTE MYELOID LEUKAEMIA WITH MYELODYSPLASIA-RELATED FEATURES Is also known as acute myeloid leukemia with multilineage dysplasia, aml with myelodysplasia-related features, aml with multilineage dysplasia
More info about ACUTE MYELOID LEUKAEMIA WITH MYELODYSPLASIA-RELATED FEATURES
SOURCES: ORPHANET
Search interest in TET2
Potential gene panels for TET2 gene
MyeloidDx by NGS Panel
United States.
By Molecular Genetics Diagnostic Laboratory Detroit Medical Center University Laboratories MyeloidDx by NGS that also includes the following genes: RUNX1 SF3B1 SRSF2 BRAF SMC1A STAG2 TP53 U2AF1 KDM6A WT1
More info about this panel United States.
TET2 Sequencing Panel
United States.
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center
This panel specifically test the TET2 gene.
More info about this panel United States.
Myelodysplastic Syndrome (sequence analysis of TET2 gene) Panel
Portugal.
By CGC Genetics
This panel specifically test the TET2 gene.
More info about this panel Portugal.
Myelodysplastic syndrome (mutations on TET2 gene) Panel
Portugal.
By CGC Genetics
This panel specifically test the TET2 gene.
More info about this panel Portugal.
Myelodysplastic syndrome susceptibility Panel
Germany.
By Centogene AG - the Rare Disease Company
This panel specifically test the TET2 gene.
More info about this panel Germany.
Myeloid Tumor Panel Panel
Germany.
By Centogene AG - the Rare Disease Company Myeloid Tumor Panel that also includes the following genes: RUNX1 SF3B1 SRSF2 BRAF SMC1A STAG2 TP53 U2AF1 KDM6A WT1
More info about this panel Germany.
Myelodysplastic syndrome, somatic Panel
Germany.
By Centogene AG - the Rare Disease Company
This panel specifically test the TET2 gene.
More info about this panel Germany.
Platelets, Coagulation disorders Panel Panel
Germany.
By CeGaT GmbH Platelets, Coagulation disorders Panel that also includes the following genes: VHL VWF ADAMTS13 TET2 DSG1 ENTPD1 ETV6 F10 F11 F12
More info about this panel Germany.
NGS HemeOnc Panel Panel
United States.
By BloodCenter of Wisconsin Diagnostic Laboratories BloodCenter of Wisconsin, part of Versiti NGS HemeOnc Panel that also includes the following genes: RUNX1 SF3B1 SRSF2 TP53 U2AF1 WT1 CBL SETBP1 PHF6 ASXL1
More info about this panel United States.
TET2 Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the TET2 gene.
More info about this panel United States.
Onco microarray for MDS/AML Panel
United States.
By Pittsburgh Cytogenetics Laboratory University of Pittsburgh Medical Center Onco microarray for MDS/AML that also includes the following genes: BCR RPN1 RUNX1 SET TCF3 TERT TFG TP53 TRPS1 WT1
More info about this panel United States.
Focus::Myeloid™ NGS Panel Panel
United States.
By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::Myeloid™ NGS Panel that also includes the following genes: RUNX1 SF3B1 SRSF2 BRAF SMC1A STAG2 TP53 U2AF1 KDM6A WT1
More info about this panel United States.
Focus::Myeloid™ NGS Panel Panel
United States.
By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::Myeloid™ NGS Panel that also includes the following genes: RUNX1 SF3B1 SRSF2 BRAF SMC1A STAG2 TP53 U2AF1 KDM6A WT1
More info about this panel United States.
Focus::MDS™ NGS Panel Panel
United States.
By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::MDS™ NGS Panel that also includes the following genes: RUNX1 SF3B1 SRSF2 BRAF STAG2 TP53 U2AF1 KDM6A WT1 CBL
More info about this panel United States.
Focus::MPN™ NGS Panel Panel
United States.
By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::MPN™ NGS Panel that also includes the following genes: RUNX1 SF3B1 SRSF2 TP53 U2AF1 CALR CBL SETBP1 ASXL1 CEBPA
More info about this panel United States.
Focus::MCL™ NGS Panel Panel
United States.
By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::MCL™ NGS Panel that also includes the following genes: SALL3 SI SMARCA4 BTK TLR2 TP53 TRAF2 NSD2 XPO1 KMT2C
More info about this panel United States.
Focus::AML™ NGS Panel Panel
United States.
By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::AML™ NGS Panel that also includes the following genes: RUNX1 SF3B1 SRSF2 BRAF STAG2 TP53 U2AF1 KDM6A WT1 CALR
More info about this panel United States.
Focus::DLBCL&FL™ NGS Panel Panel
United States.
By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::DLBCL&FL™ NGS Panel that also includes the following genes: BCL6 SGK1 BRAF ARID1A BTK STAT3 STAT6 SYK TNFAIP3 FAS
More info about this panel United States.
Focus::Lymphoma™ NGS Panel Panel
United States.
By Cancer Genetics, Inc. Cancer Genetics, Inc. Focus::Lymphoma™ NGS Panel that also includes the following genes: BCL6 SGK1 BRAF ARID1A BTK STAT3 STAT6 SYK TNFAIP3 FAS
More info about this panel United States.
Hematopoietic Disorders Gene Set Panel
United States.
By Genomics and Pathology Services Washington University in St. Louis Hematopoietic Disorders Gene Set that also includes the following genes: RUNX1 SF3B1 SRSF2 BRAF STAG2 TERT TP53 U2AF1 KDM6A NSD1
More info about this panel United States.
FoundationOne® Heme Panel
United States.
By Foundation Medicine, Inc. FoundationOne® Heme that also includes the following genes: BCL6 BCL7A ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1
More info about this panel United States.
NeoTYPE® Discovery Profile for Solid Tumors Panel
United States.
By NeoGenomics Laboratories NeoGenomics Laboratories, Inc. NeoTYPE® Discovery Profile for Solid Tumors that also includes the following genes: BCL6 ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1 FOXL2
More info about this panel United States.
Caris MI TumorSeek 592-Gene NGS Panel Panel
United States.
By Caris Life Sciences Caris MI TumorSeek 592-Gene NGS Panel that also includes the following genes: BCL6 BCL7A BCL9 BCR ROS1 RPL10 RPL22 RPL5 RPN1 RUNX1
More info about this panel United States.
OmniSeq Comprehensive Panel
United States.
By OmniSeq, Inc. OmniSeq Comprehensive that also includes the following genes: RHEB BCL9 ROS1 RPS6KB1 SF3B1 FOXL2 BRAF BRCA1 BRCA2 SMARCB1
More info about this panel United States.
Providence Personalized Medicine Panel - Solid Tumor Panel
United States.
By Providence Regional Laboratories Providence Health and Services Providence Personalized Medicine Panel - Solid Tumor that also includes the following genes: BCR ROS1 RUNX1 SDHA SDHB SDHC SDHD SF3B1 SRSF2 FOXL2
More info about this panel United States.
Somatic Myelodysplastic Syndrome, Sequencing TET2 Gene Panel
Spain.
By Reference Laboratory Genetics
This panel specifically test the TET2 gene.
More info about this panel Spain.
152 Integrated Advantage NGS Solid Tumor Panel Panel
United States.
By Integrated Molecular Diagnostics Pathology, Inc. 152 Integrated Advantage NGS Solid Tumor Panel that also includes the following genes: ROS1 RRM1 SLCO1B1 BRAF BRCA1 SLC29A1 BRCA2 SMO SPARC SRC
More info about this panel United States.
Tempus xT assay Panel
United States.
By Tempus Labs, Inc. Tempus xT assay that also includes the following genes: BCL6 RIT1 BCL7A BCR ROS1 RPL5 RPS15 RPS6KB1 RUNX1 RXRA
More info about this panel United States.
Tempus xO assay Panel
United States.
By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2
More info about this panel United States.
CEN4GEN Hematological malignancies (somatic genetic testing): Sequencing Panel Panel
Canada.
By CEN4GEN Institute for Genomics and Molecular Diagnostics CEN4GEN Hematological malignancies (somatic genetic testing): Sequencing Panel that also includes the following genes: RUNX1 BRAF TP53 ASXL1 CEBPA TET2 DNMT3A FLT3 ALK IDH1
More info about this panel Canada.
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