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  3. TDRD9

TDRD9 gene related symptoms and diseases

All the information presented here about the TDRD9 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,ORPHANET,NCBIGENE,HGNC, Mendelian Rare Disease Search Engine.

Table of contents:

Top 5 symptoms and clinical features associated to TDRD9 gene

Symptoms // Phenotype % Cases
Azoospermia Very Common - Between 80% and 100% cases
Infertility Uncommon - Between 30% and 50% cases
Male infertility Uncommon - Between 30% and 50% cases
Cryptozoospermia Uncommon - Between 30% and 50% cases
Decreased testicular size Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with TDRD9 gene alterations may also develop some of the following symptoms and phenotypes:

  • Not very common - Between 30% and 50% cases

  • Increased circulating gonadotropin level
  • Abnormal spermatogenesis
  • Obstructive azoospermia
  • Non-obstructive azoospermia

Rare diseases associated to TDRD9 gene

Here you will find a list of rare diseases related to the TDRD9. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


SPERMATOGENIC FAILURE 30; SPGF30

Description

Spermatogenic failure-30 is characterized by male infertility due to nonobstructive azoospermia or cryptozoospermia. The few sperm that have been observed are immotile and have small heads. Testicular histology in azoospermic patients shows incomplete maturation arrest, with a Sertoli cell-only pattern in some areas (Arafat et al., 2017).For a discussion of phenotypic and genetic heterogeneity of spermatogenic failure, see {258150}.

Most common symptoms of SPERMATOGENIC FAILURE 30; SPGF30

  • Infertility
  • Azoospermia
  • Male infertility
  • Cryptozoospermia


More info about SPERMATOGENIC FAILURE 30; SPGF30

SOURCES: OMIM

MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION

Description

Male infertility with azoospermia or oligospermia due to single gene mutation is a rare, genetic male infertility due to sperm disorder characterized by the absence of a measurable amount of spermatozoa in the ejaculate (azoospermia), or a number of sperm in the ejaculate inferior to 15 million/mL (oligozoospermia), resulting from a mutation in a single gene known to cause azoo- or oligo-spermia. Sperm morphology may be normal.

Most common symptoms of MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION

  • Decreased testicular size
  • Azoospermia
  • Increased circulating gonadotropin level
  • Abnormal spermatogenesis
  • Obstructive azoospermia


More info about MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION

SOURCES: ORPHANET


Potential gene panels for TDRD9 gene

TDRD9 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the TDRD9 gene.

More info about this panel
United States.

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