SYCE1 gene related symptoms and diseases

All the information presented here about the SYCE1 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: HGNC,ORPHANET,NCBIGENE,OMIM, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to SYCE1 gene

Symptoms // Phenotype % Cases
Azoospermia Common - Between 50% and 80% cases
Non-obstructive azoospermia Common - Between 50% and 80% cases
Increased circulating gonadotropin level Common - Between 50% and 80% cases
Aspiration Uncommon - Between 30% and 50% cases
Varicocele Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with SYCE1 gene alterations may also develop some of the following symptoms and phenotypes:
  • Not very common - Between 30% and 50% cases

  • Microphthalmia
  • Amenorrhea
  • Primary amenorrhea
  • Macular dystrophy
  • Decreased testicular size
  • Abnormal spermatogenesis
  • Obstructive azoospermia

Rare diseases associated to SYCE1 gene

Here you will find a list of rare diseases related to the SYCE1. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


SPERMATOGENIC FAILURE 15; SPGF15

Most common symptoms of SPERMATOGENIC FAILURE 15; SPGF15

  • Aspiration
  • Azoospermia
  • Varicocele
  • Non-obstructive azoospermia


More info about SPERMATOGENIC FAILURE 15; SPGF15

SOURCES: OMIM

PREMATURE OVARIAN FAILURE 12; POF12

Most common symptoms of PREMATURE OVARIAN FAILURE 12; POF12

  • Microphthalmia
  • Amenorrhea
  • Primary amenorrhea
  • Macular dystrophy
  • Increased circulating gonadotropin level


More info about PREMATURE OVARIAN FAILURE 12; POF12

SOURCES: OMIM

MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION

Description

Male infertility with azoospermia or oligospermia due to single gene mutation is a rare, genetic male infertility due to sperm disorder characterized by the absence of a measurable amount of spermatozoa in the ejaculate (azoospermia), or a number of sperm in the ejaculate inferior to 15 million/mL (oligozoospermia), resulting from a mutation in a single gene known to cause azoo- or oligo-spermia. Sperm morphology may be normal.

Most common symptoms of MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION

  • Decreased testicular size
  • Azoospermia
  • Increased circulating gonadotropin level
  • Abnormal spermatogenesis
  • Obstructive azoospermia


More info about MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION

SOURCES: ORPHANET


Potential gene panels for SYCE1 gene

Female Infertility Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Female Infertility Sequencing Panel with CNV Detection that also includes the following genes: BMP15 SEMA3A SEMA3E FOXL2 SOX10 SOX2 SOX3 SOX9 SRA1 SRD5A2

More info about this panel
United States.

Male Infertility Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Male Infertility Sequencing Panel with CNV Detection that also includes the following genes: SEMA3A SEMA3E FOXL2 BRDT SOX10 SOX2 SOX3 SOX9 SRA1 SRD5A2

More info about this panel
United States.

Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection that also includes the following genes: ROR2 SALL1 BMP15 BMP4 SEMA3A SEMA3E BMP7 FOXL2 BRDT SOS1

More info about this panel
United States.

SYCE1 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the SYCE1 gene.

More info about this panel
United States.

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