SPG37 gene related symptoms and diseases

All the information presented here about the SPG37 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: HGNC,NCBIGENE,ORPHANET, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to SPG37 gene

Symptoms // Phenotype % Cases
Seizures Very Common - Between 80% and 100% cases
Impaired vibratory sensation Very Common - Between 80% and 100% cases
Progressive pes cavus Very Common - Between 80% and 100% cases
Spinal cord lesion Very Common - Between 80% and 100% cases
Hyperreflexia in upper limbs Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with SPG37 gene alterations may also develop some of the following symptoms and phenotypes:
  • Commonly - More than 50% cases

  • Abnormality of the cerebrospinal fluid
  • Upper limb spasticity
  • Degeneration of the lateral corticospinal tracts
  • Impaired vibration sensation in the lower limbs
  • Progressive spastic paraplegia
  • Ankle clonus
  • Lower limb hyperreflexia
  • Urinary urgency

And 14 more phenotypes, you can get all of them using our tools for rare diseases.

Rare diseases associated to SPG37 gene

Here you will find a list of rare diseases related to the SPG37. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA TYPE 37

Alternate names

AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA TYPE 37 Is also known as spg37

Description

Autosomal dominant spastic paraplegia type 37 is a pure form of hereditary spastic paraplegia characterized by a childhood- to adulthood-onset of slowly progressive spastic gait, extensor plantar responses, brisk tendon reflexes in arms and legs, decreased vibration sense at ankles and urinary dysfunction. Ankle clonus is also reported in some patients.

Most common symptoms of AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA TYPE 37

  • Seizures
  • Hyperreflexia
  • Fatigue
  • Babinski sign
  • Difficulty walking


More info about AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA TYPE 37

SOURCES: ORPHANET OMIM MESH



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