1. Mendelian
  2. Rare Disease Genes
  3. SPG25

SPG25 gene related symptoms and diseases

All the information presented here about the SPG25 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,NCBIGENE,HGNC, Mendelian Rare Disease Search Engine.

Table of contents:

Top 5 symptoms and clinical features associated to SPG25 gene

Symptoms // Phenotype % Cases
Pain Very Common - Between 80% and 100% cases
Spastic paraplegia Very Common - Between 80% and 100% cases
Congenital cataract Very Common - Between 80% and 100% cases
Sensory neuropathy Very Common - Between 80% and 100% cases
Sensorimotor neuropathy Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with SPG25 gene alterations may also develop some of the following symptoms and phenotypes:

  • Commonly - More than 50% cases

  • Paraparesis
  • Back pain
  • Congenital glaucoma
  • Spinal cord compression
  • Abnormality of peripheral nerve conduction
  • Lower limb pain
  • Neck pain
  • Abnormality of the lumbar spine

And 3 more phenotypes, you can get all of them using our tools for rare diseases.

Rare diseases associated to SPG25 gene

Here you will find a list of rare diseases related to the SPG25. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


AUTOSOMAL RECESSIVE SPASTIC PARAPLEGIA TYPE 25

Alternate names

AUTOSOMAL RECESSIVE SPASTIC PARAPLEGIA TYPE 25 Is also known as disc herniation with spastic paraplegia, autosomal recessive, autosomal recessive spastic paraplegia-disc herniation syndrome, spg25

Description

Autosomal recessive spastic paraplegia type 25 (SPG25) is a rare, complex type of hereditary spastic paraplegia characterized by adult-onset spastic paraplegia associated with spinal pain that radiates to the upper or lower limbs and is related to disk herniation (with minor spondylosis), as well as mild sensorimotor neuropathy. The SPG25 phenotype has been mapped to a locus on chromosome 6q23-q24.1.

Most common symptoms of AUTOSOMAL RECESSIVE SPASTIC PARAPLEGIA TYPE 25

  • Pain
  • Spastic paraplegia
  • Congenital cataract
  • Sensory neuropathy
  • Sensorimotor neuropathy


More info about AUTOSOMAL RECESSIVE SPASTIC PARAPLEGIA TYPE 25

SOURCES: OMIM ORPHANET MESH



If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like LARS2 GATA2 CCNF SYNE2 ROBO3 APOB ST3GAL4