SNCB gene related symptoms and diseases
All the information presented here about the SNCB gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,OMIM,HGNC, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to SNCB gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Cognitive impairment | Very Common - Between 80% and 100% cases |
| Bradykinesia | Very Common - Between 80% and 100% cases |
| Vertical supranuclear gaze palsy | Very Common - Between 80% and 100% cases |
| Senile plaques | Very Common - Between 80% and 100% cases |
| Supranuclear gaze palsy | Very Common - Between 80% and 100% cases |
Other less frequent symptoms and clinical features
Patients with SNCB gene alterations may also develop some of the following symptoms and phenotypes:Commonly - More than 50% cases
- Visual hallucinations
- Lewy bodies
- Delusions
- Neurofibrillary tangles
- Loss of consciousness
- Alzheimer disease
- Spastic paraparesis
- Paraparesis
And 20 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to SNCB gene
Here you will find a list of rare diseases related to the SNCB. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
DEMENTIA, LEWY BODY; DLB
Alternate names
DEMENTIA, LEWY BODY; DLB Is also known as lewy body dementia, diffuse lewy body disease
Description
Dementia with Lewy bodies (DLB) is a neurodegenerative disorder clinically characterized by dementia and parkinsonism, often with fluctuating cognitive function, visual hallucinations, falls, syncopal episodes, and sensitivity to neuroleptic medication. Pathologically, Lewy bodies are present in a pattern more widespread than usually observed in Parkinson disease (see PD; {168600}). Alzheimer disease (AD )-associated pathology and spongiform changes may also be seen (McKeith et al., 1996; Mizutani, 2000; McKeith et al., 2005).
Most common symptoms of DEMENTIA, LEWY BODY; DLB
- Cognitive impairment
- Dysarthria
- Depressivity
- Pneumonia
- Dementia
More info about DEMENTIA, LEWY BODY; DLB
Search interest in SNCB
Potential gene panels for SNCB gene
MitoMet®Plus aCGH Analysis Panel
United States.
By Baylor Miraca Genetics Laboratories MitoMet®Plus aCGH Analysis that also includes the following genes: RGS9 RHO GRK1 RLBP1 RNASEL BCS1L RP1 RP2 RP9 RPE65
More info about this panel United States.
Dementia with Lewy body (sequence analysis of SNCB gene) Panel
Portugal.
By CGC Genetics
This panel specifically test the SNCB gene.
More info about this panel Portugal.
Parkinson disease (NGS panel for 33 genes) Panel
Portugal.
By CGC Genetics Parkinson disease (NGS panel for 33 genes) that also includes the following genes: SLC6A3 SNCA SNCAIP SNCB SYNJ1 TAF1 TH GIGYF2 UCHL1 VPS35
More info about this panel Portugal.
Alzheimer disease (NGS panel for 8 genes) Panel
Portugal.
By CGC Genetics Alzheimer disease (NGS panel for 8 genes) that also includes the following genes: SNCA SNCB SORL1 APOE APP PRNP PSEN1 PSEN2
More info about this panel Portugal.
Hereditary dementias (NGS panel for 28 genes) Panel
Portugal.
By CGC Genetics Hereditary dementias (NGS panel for 28 genes) that also includes the following genes: SNCA SNCB SORL1 TARDBP TIMM8A TUBA4A TYROBP UBQLN2 VCP CHCHD10
More info about this panel Portugal.
Parkinson Disease and Parkinsonism Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Parkinson Disease and Parkinsonism Sequencing Panel with CNV Detection that also includes the following genes: SLC20A2 SLC6A3 SNCA SNCB SPG11 SPR SYNJ1 TAF1 TARDBP TWNK
More info about this panel United States.
AllNeuro panel Panel
Germany.
By Centogene AG - the Rare Disease Company AllNeuro panel that also includes the following genes: BCS1L ROR2 RPL10 BDNF RPS6KA3 RTN2 RYR1 SACS BIN1 SBF1
More info about this panel Germany.
Parkinsons disease panel Panel
Germany.
By Centogene AG - the Rare Disease Company Parkinsons disease panel that also includes the following genes: SLC6A3 SNCA SNCB SPR SYNJ1 TAF1 TH GIGYF2 UCHL1 VPS35
More info about this panel Germany.
NGS panel - dementia Panel
Netherlands.
By Genome Diagnostics VU University Medical Center NGS panel - dementia that also includes the following genes: SNCA SNCB SOD1 SORL1 SQSTM1 TARDBP TYROBP UBAP1 UBQLN2 VAPB
More info about this panel Netherlands.
Parkinson-Alzheimer-Dementia NGS Panel Panel
United States.
By Fulgent Genetics Fulgent Genetics Parkinson-Alzheimer-Dementia NGS Panel that also includes the following genes: SLC6A3 SNCA SNCB TAF1 TH TYROBP UCHL1 VPS35 FBXO7 AAAS
More info about this panel United States.
SNCB Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the SNCB gene.
More info about this panel United States.
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