SNCA gene related symptoms and diseases
All the information presented here about the SNCA gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: HGNC,ORPHANET,OMIM,NCBIGENE, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to SNCA gene
Symptoms // Phenotype | % Cases |
---|---|
Dementia | Very Common - Between 80% and 100% cases |
Rigidity | Very Common - Between 80% and 100% cases |
Bradykinesia | Common - Between 50% and 80% cases |
Lewy bodies | Common - Between 50% and 80% cases |
Parkinsonism | Common - Between 50% and 80% cases |
Other less frequent symptoms and clinical features
Patients with SNCA gene alterations may also develop some of the following symptoms and phenotypes:Commonly - More than 50% cases
- Dystonia
- Depressivity
- Dysarthria
- Tremor
- Dysphagia
- Dyskinesia
- Gliosis
Not very common - Between 30% and 50% cases
- Sleep disturbance
And 179 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to SNCA gene
Here you will find a list of rare diseases related to the SNCA. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
DEMENTIA, LEWY BODY; DLB
Alternate names
DEMENTIA, LEWY BODY; DLB Is also known as lewy body dementia, diffuse lewy body disease
Description
Dementia with Lewy bodies (DLB) is a neurodegenerative disorder clinically characterized by dementia and parkinsonism, often with fluctuating cognitive function, visual hallucinations, falls, syncopal episodes, and sensitivity to neuroleptic medication. Pathologically, Lewy bodies are present in a pattern more widespread than usually observed in Parkinson disease (see PD; {168600}). Alzheimer disease (AD )-associated pathology and spongiform changes may also be seen (McKeith et al., 1996; Mizutani, 2000; McKeith et al., 2005).
Most common symptoms of DEMENTIA, LEWY BODY; DLB
- Cognitive impairment
- Dysarthria
- Depressivity
- Pneumonia
- Dementia
More info about DEMENTIA, LEWY BODY; DLB
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT; PARK1
Alternate names
PARKINSON DISEASE 1, AUTOSOMAL DOMINANT; PARK1 Is also known as parkinson disease 1, autosomal dominant lewy body
Description
Parkinson disease is the second most common neurogenic disorder after Alzheimer disease (AD ), affecting approximately 1% of the population over age 50. Clinical manifestations include resting tremor, muscular rigidity, bradykinesia, and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia (Polymeropoulos et al., 1996).For a general phenotypic description and a discussion of genetic heterogeneity of Parkinson disease, see {168600}.
Most common symptoms of PARKINSON DISEASE 1, AUTOSOMAL DOMINANT; PARK1
- Spasticity
- Delayed speech and language development
- Hyperreflexia
- Dysarthria
- Tremor
More info about PARKINSON DISEASE 1, AUTOSOMAL DOMINANT; PARK1
PARKINSON DISEASE 4, AUTOSOMAL DOMINANT; PARK4
Alternate names
PARKINSON DISEASE 4, AUTOSOMAL DOMINANT; PARK4 Is also known as parkinson disease 4, autosomal dominant lewy body
Most common symptoms of PARKINSON DISEASE 4, AUTOSOMAL DOMINANT; PARK4
- Generalized hypotonia
- Cognitive impairment
- Tremor
- Dementia
- Weight loss
More info about PARKINSON DISEASE 4, AUTOSOMAL DOMINANT; PARK4
WILSON DISEASE
Alternate names
WILSON DISEASE Is also known as wd, hepatolenticular degeneration, wnd
Description
Wilson disease is a very rare inherited multisystemic disease presenting non-specific neurological, hepatic, psychiatric or osseo-muscular manifestations due to excessive copper deposition in the body.
Most common symptoms of WILSON DISEASE
- Intellectual disability
- Growth delay
- Neoplasm
- Failure to thrive
- Spasticity
More info about WILSON DISEASE
PARKINSONIAN-PYRAMIDAL SYNDROME
Alternate names
PARKINSONIAN-PYRAMIDAL SYNDROME Is also known as pkps, pallidopyramidal syndrome, parkinsonian-pyramidal syndrome, pallido-pyramidal syndrome
Description
Parkinsonian-pyramidal syndrome is a rare, genetic, neurological disorder characterized by the association of both parkinsonian (i.e. bradykinesia, rigidity and/or rest tremor) and pyramidal (i.e. increased reflexes, extensor plantar reflexes, pyramidal weakness or spasticity) manifestations, which vary according to the underlying associated disease (e.g. neurodegenerative disease, inborn errors of metabolism).
Most common symptoms of PARKINSONIAN-PYRAMIDAL SYNDROME
- Spasticity
- Cognitive impairment
- Hyperreflexia
- Dysarthria
- Tremor
More info about PARKINSONIAN-PYRAMIDAL SYNDROME
YOUNG-ONSET PARKINSON DISEASE
Alternate names
YOUNG-ONSET PARKINSON DISEASE Is also known as yopd, early-onset parkinson disease
Description
Young-onset Parkinson disease (YOPD) is a form of Parkinson disease (PD), characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most YOPD forms.
More info about YOUNG-ONSET PARKINSON DISEASE
SOURCES: ORPHANET
HEREDITARY LATE-ONSET PARKINSON DISEASE
Alternate names
HEREDITARY LATE-ONSET PARKINSON DISEASE Is also known as autosomal dominant late-onset parkinson disease, lopd
Description
Hereditary late-onset Parkinson disease (LOPD) is a form of Parkinson disease (PD), characterized by an age of onset of more than 50 years, tremor at rest, gait complaints and falls, bradykinesia, rigidity and painful cramps. Patients usually present a low risk of developing non motor symptoms, dystonia, dyskinesia and levodopa-induced dyskinesia (LID).
Most common symptoms of HEREDITARY LATE-ONSET PARKINSON DISEASE
- Dysphagia
- Dystonia
- Depressivity
- Dementia
- Cerebral cortical atrophy
More info about HEREDITARY LATE-ONSET PARKINSON DISEASE
SOURCES: ORPHANET
Search interest in SNCA
Potential gene panels for SNCA gene
Alpha Synuclein (SNCA) Duplication/Deletion Test Panel
By Athena Diagnostics Inc
This panel specifically test the SNCA gene.
More info about this panelAlpha Synuclein (SNCA) DNA Sequencing Test Panel
By Athena Diagnostics Inc
This panel specifically test the SNCA gene.
More info about this panelComplete Parkinsonism Evaluation Panel
By Athena Diagnostics Inc Complete Parkinsonism Evaluation that also includes the following genes: SNCA PINK1 PARK7 LRRK2 PRKN
More info about this panelMovement Disorders Panel Panel
By Knight Diagnostic Laboratories - Molecular Diagnostic Center Oregon Health & Science University Movement Disorders Panel that also includes the following genes: SCP2 SGCE SLC20A2 SLC2A1 SLC6A3 SNCA SPR SQSTM1 SUCLA2 SUOX
More info about this panelParkinson's Disease Panel
By Knight Diagnostic Laboratories - Molecular Diagnostic Center Oregon Health & Science University Parkinson's Disease that also includes the following genes: SLC6A3 SNCA TAF1 TH VPS35 FBXO7 PINK1 PARK7 LRRK2 CSF1R
More info about this panelSNCA Panel
By Institute for Human Genetics University Clinic Freiburg
This panel specifically test the SNCA gene.
More info about this panelSNCA. Complete sequencing Panel
By Instituto de Medicina Genomica Instituto de Medicina Genomica
This panel specifically test the SNCA gene.
More info about this panelSNCA. MLPA testing Panel
By Instituto de Medicina Genomica Instituto de Medicina Genomica
This panel specifically test the SNCA gene.
More info about this panelSNCA. MLPA testing Panel
By Instituto de Medicina Genomica Instituto de Medicina Genomica
This panel specifically test the SNCA gene.
More info about this panelSNCA. Complete sequencing Panel
By Instituto de Medicina Genomica Instituto de Medicina Genomica
This panel specifically test the SNCA gene.
More info about this panelParkinson disease (NGS panel for 10 genes) Panel
By CGC Genetics Parkinson disease (NGS panel for 10 genes) that also includes the following genes: SNCA VPS35 FBXO7 PINK1 DNAJC6 PARK7 LRRK2 ATP13A2 PRKN PLA2G6
More info about this panelParkinson disease (NGS panel for 33 genes) Panel
By CGC Genetics Parkinson disease (NGS panel for 33 genes) that also includes the following genes: SLC6A3 SNCA SNCAIP SNCB SYNJ1 TAF1 TH GIGYF2 UCHL1 VPS35
More info about this panelParkinson disease 1/4 (PARK1/4, deletion/duplication analysis on SNCA gene) Panel
By CGC Genetics
This panel specifically test the SNCA gene.
More info about this panelDementia with Lewy bodies (sequence analysis of SNCA gene) Panel
By CGC Genetics
This panel specifically test the SNCA gene.
More info about this panelDementia with Lewy bodies (deletion/duplication analisis on SNCA gene) Panel
By CGC Genetics
This panel specifically test the SNCA gene.
More info about this panelParkinson disease 1/4 (PARK1/4, sequence analysis of SNCA gene) Panel
By CGC Genetics
This panel specifically test the SNCA gene.
More info about this panelAlzheimer disease (NGS panel for 8 genes) Panel
By CGC Genetics Alzheimer disease (NGS panel for 8 genes) that also includes the following genes: SNCA SNCB SORL1 APOE APP PRNP PSEN1 PSEN2
More info about this panelHereditary dementias (NGS panel for 28 genes) Panel
By CGC Genetics Hereditary dementias (NGS panel for 28 genes) that also includes the following genes: SNCA SNCB SORL1 TARDBP TIMM8A TUBA4A TYROBP UBQLN2 VCP CHCHD10
More info about this panelParkinson's Disease via SNCA Gene Sequencing with CNV Detection Panel
By PreventionGenetics PreventionGenetics
This panel specifically test the SNCA gene.
More info about this panelParkinson Disease Sequencing Panel with CNV Detection Panel
By PreventionGenetics PreventionGenetics Parkinson Disease Sequencing Panel with CNV Detection that also includes the following genes: SLC6A3 SNCA SPR SYNJ1 TAF1 GIGYF2 UCHL1 VPS35 FBXO7 HTRA2
More info about this panelParkinson Disease and Parkinsonism Sequencing Panel with CNV Detection Panel
By PreventionGenetics PreventionGenetics Parkinson Disease and Parkinsonism Sequencing Panel with CNV Detection that also includes the following genes: SLC20A2 SLC6A3 SNCA SNCB SPG11 SPR SYNJ1 TAF1 TARDBP TWNK
More info about this panelNeurogenetic Disorders - panels Panel
By MGZ Medical Genetics Center Neurogenetic Disorders - panels that also includes the following genes: BCS1L RTN2 RYR1 SACS SCN1A SCN1B SCN2A SCN8A SCO1 SCO2
More info about this panelPARK1 Parkinsonism Panel
By Centogene AG - the Rare Disease Company
This panel specifically test the SNCA gene.
More info about this panelAllNeuro panel Panel
By Centogene AG - the Rare Disease Company AllNeuro panel that also includes the following genes: BCS1L ROR2 RPL10 BDNF RPS6KA3 RTN2 RYR1 SACS BIN1 SBF1
More info about this panelParkinsons disease panel Panel
By Centogene AG - the Rare Disease Company Parkinsons disease panel that also includes the following genes: SLC6A3 SNCA SNCB SPR SYNJ1 TAF1 TH GIGYF2 UCHL1 VPS35
More info about this panelParkinson Syndrome, autosomal dominant Panel Panel
By CeGaT GmbH Parkinson Syndrome, autosomal dominant Panel that also includes the following genes: SNCA VPS35 HTRA2 LRRK2 CHCHD2 DNAJC13 EIF4G1 GBA PRKAR1B RAB29
More info about this panelParkinson all Panel Panel
By CeGaT GmbH Parkinson all Panel that also includes the following genes: ATXN2 SLC6A3 SNCA SPG11 SPR SYNJ1 TAF1 TH VPS35 FBXO7
More info about this panelSingle gene testing SNCA Panel
By CeGaT GmbH
This panel specifically test the SNCA gene.
More info about this panelSNCA Panel
By Innovagenomics Innovagenomics S.L
This panel specifically test the SNCA gene.
More info about this panelParkinson Disease Panel
By Asper Biogene Asper Biogene LLC Parkinson Disease that also includes the following genes: SLC6A3 SNCA SPR SYNJ1 TAF1 TH GIGYF2 UCHL1 VPS35 FBXO7
More info about this panelInvitae Hereditary Parkinson's Disease and Parkinsonism Panel Panel
By Invitae Invitae Hereditary Parkinson's Disease and Parkinsonism Panel that also includes the following genes: SLC6A3 SNCA SPR TH VPS35 FBXO7 PINK1 DNAJC6 PARK7 LRRK2
More info about this panelInvitae Combined Hereditary Dementia and Amyotrophic Lateral Sclerosis Panel Panel
By Invitae Invitae Combined Hereditary Dementia and Amyotrophic Lateral Sclerosis Panel that also includes the following genes: SNCA SOD1 SPG11 TARDBP TBK1 TFG UBQLN2 VAPB VCP CHCHD10
More info about this panelParkinson disease 1: SNCA (PARK1) gene (exons 3-4) screening Panel
By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases
This panel specifically test the SNCA gene.
More info about this panelParkinson disease 1: SNCA (PARK1) gene sequence analysis Panel
By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases
This panel specifically test the SNCA gene.
More info about this panelParkinson disease 1: SNCA (PARK1) gene deletions-duplications analysis (MLPA) Panel
By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases
This panel specifically test the SNCA gene.
More info about this panelPARKINSON DISEASE Panel
By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases PARKINSON DISEASE that also includes the following genes: SNCA TAF1 VPS35 FBXO7 PINK1 PARK7 LRRK2 ATP13A2 PRKN PLA2G6
More info about this panelNGS panel - dementia Panel
By Genome Diagnostics VU University Medical Center NGS panel - dementia that also includes the following genes: SNCA SNCB SOD1 SORL1 SQSTM1 TARDBP TYROBP UBAP1 UBQLN2 VAPB
More info about this panelSNCA(PARK1) - Gene Sequencing & Del/Dup analysis Panel
By Genome Diagnostics VU University Medical Center
This panel specifically test the SNCA gene.
More info about this panelNGS panel - Parkinson Panel
By Genome Diagnostics VU University Medical Center NGS panel - Parkinson that also includes the following genes: ATXN2 SLC18A2 SLC6A3 SNCA SPR SYNJ1 TAF1 TH GIGYF2 UCHL1
More info about this panelParkinson-Alzheimer-Dementia NGS Panel Panel
By Fulgent Genetics Fulgent Genetics Parkinson-Alzheimer-Dementia NGS Panel that also includes the following genes: SLC6A3 SNCA SNCB TAF1 TH TYROBP UCHL1 VPS35 FBXO7 AAAS
More info about this panelSNCA Panel
By Fulgent Genetics Fulgent Genetics
This panel specifically test the SNCA gene.
More info about this panelDementia Panel Panel
By Blueprint Genetics Dementia Panel that also includes the following genes: SNCA SORL1 TARDBP TUBA4A UBE3A UBQLN2 VCP TREM2 RNF216 CSF1R
More info about this panelParkinson Disease Panel Panel
By Blueprint Genetics Parkinson Disease Panel that also includes the following genes: SLC20A2 SLC6A3 SNCA SPR SYNJ1 TH VPS35 FBXO7 PINK1 DNAJC6
More info about this panelParkinson disease 4 Panel
By Bioarray
This panel specifically test the SNCA gene.
More info about this panelParkinson disease type 1 Panel
By Bioarray
This panel specifically test the SNCA gene.
More info about this panelParkinson Disease, Early Onset NGS and Deletion/Duplication Panel Panel
By DDC Clinic Molecular Diagnostics Laboratory DDC Clinic, Center for Special Needs Children Parkinson Disease, Early Onset NGS and Deletion/Duplication Panel that also includes the following genes: SNCA FBXO7 PINK1 DNAJC6 PARK7 ATP13A2 GCH1 PRKN PLA2G6
More info about this panelSNCA Gene Sequencing and Deletion/Duplication Analysis Panel
By DDC Clinic Molecular Diagnostics Laboratory DDC Clinic, Center for Special Needs Children
This panel specifically test the SNCA gene.
More info about this panelParkinson Disease (SNCA gene) Panel
By Diagnostic Service Facility University of Antwerp
This panel specifically test the SNCA gene.
More info about this panelPARKINSONISM, LEWY BODY (PARK1/ PARK4) Panel
By Laboratorio de Genetica Clinica SL
This panel specifically test the SNCA gene.
More info about this panelPARKINSON NGS PANEL Panel
By Laboratorio de Genetica Clinica SL PARKINSON NGS PANEL that also includes the following genes: SLC6A3 SMPD1 SNCA SYNJ1 UCHL1 VPS35 FBXO7 HTRA2 PINK1 DNAJC6
More info about this panelParkinson Disease Type 4, Sequencing SNCA Gene Panel
By Reference Laboratory Genetics
This panel specifically test the SNCA gene.
More info about this panelParkinson Disease Type 1, Sequencing Exons (3-4) SNCA (PARK1) Gene Panel
By Reference Laboratory Genetics
This panel specifically test the SNCA gene.
More info about this panelParkinson Disease Type 4, Deletions-Duplications (MLPA) SNCA Gene Panel
By Reference Laboratory Genetics
This panel specifically test the SNCA gene.
More info about this panelParkinson Disease , Deletions-Duplications (MLPA) SNCA, PARK2, PINK1, PARK7, LRRK2, UCHL1 Genes Panel
By Reference Laboratory Genetics Parkinson Disease , Deletions-Duplications (MLPA) SNCA, PARK2, PINK1, PARK7, LRRK2, UCHL1 Genes that also includes the following genes: SNCA UCHL1 PINK1 PARK7 LRRK2 PRKN
More info about this panelParkinson Disease , Panel Massive Sequencing (NGS) 11 Genes Panel
By Reference Laboratory Genetics Parkinson Disease , Panel Massive Sequencing (NGS) 11 Genes that also includes the following genes: SLC6A3 SNCA TAF1 VPS35 FBXO7 PINK1 PARK7 LRRK2 ATP13A2 PRKN
More info about this panelParkinson Disease: gene sequencing panel Panel
By CEN4GEN Institute for Genomics and Molecular Diagnostics Parkinson Disease: gene sequencing panel that also includes the following genes: SLC6A3 SNCA TAF1 VPS35 FBXO7 PINK1 PARK7 LRRK2 ATP13A2 PRKN
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