SAA1 gene related symptoms and diseases
All the information presented here about the SAA1 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,ORPHANET,HGNC,OMIM, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to SAA1 gene
Symptoms // Phenotype | % Cases |
---|---|
Hepatomegaly | Very Common - Between 80% and 100% cases |
Chronic kidney disease | Very Common - Between 80% and 100% cases |
Cardiac amyloidosis | Very Common - Between 80% and 100% cases |
Abnormal cardiac ventricle morphology | Very Common - Between 80% and 100% cases |
Renal amyloidosis | Very Common - Between 80% and 100% cases |
Other less frequent symptoms and clinical features
Patients with SAA1 gene alterations may also develop some of the following symptoms and phenotypes:Commonly - More than 50% cases
- Abnormal oral mucosa morphology
- Abnormal echocardiogram
- Abnormal renal physiology
- Enlarged kidney
- Acute kidney injury
- Amyloidosis
- Malnutrition
- Adrenal insufficiency
And 17 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to SAA1 gene
Here you will find a list of rare diseases related to the SAA1. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
AA AMYLOIDOSIS
Alternate names
AA AMYLOIDOSIS Is also known as secondary amyloidosis, inflammatory amyloidosis, reactive amyloidosis
Description
Secondary amyloidosis is a form of amyloidosis (see this term), that complicates chronic inflammatory disorders (mainly rheumatoid arthritis, see this term) and is characterized by the aggregation and deposition of amyloid fibrils composed of serum amyloid A protein, an acute phase reactant. Although spleen, suprarenal gland, liver and gut are frequent sites of amyloid deposition, the clinical picture is dominated by renal involvement.
Most common symptoms of AA AMYLOIDOSIS
- Hepatomegaly
- Vomiting
- Abnormal heart morphology
- Abdominal pain
- Hypothyroidism
More info about AA AMYLOIDOSIS
SOURCES: ORPHANET
Search interest in SAA1
Potential gene panels for SAA1 gene
Familial mediterranean fever Panel
By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders Familial mediterranean fever that also includes the following genes: SAA1 TNFRSF1A MEFV
More info about this panelSAA1 Panel
By Fulgent Genetics Fulgent Genetics
This panel specifically test the SAA1 gene.
More info about this panelIf you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like RAD51B MGAT2 PIEZO1 WFS1 ABCB4 BRWD3 TWIST2