PRLR gene related symptoms and diseases
All the information presented here about the PRLR gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,NCBIGENE,HGNC,OMIM, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to PRLR gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Osteoporosis | Uncommon - Between 30% and 50% cases |
| Hypogonadism | Uncommon - Between 30% and 50% cases |
| Osteopenia | Uncommon - Between 30% and 50% cases |
| Infertility | Uncommon - Between 30% and 50% cases |
| Amenorrhea | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with PRLR gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Menorrhagia
- Hypopituitarism
- Oligomenorrhea
- Prolactin excess
- Galactorrhea
- Female hypogonadism
- Hemorrhagic ovarian cyst
Rare diseases associated to PRLR gene
Here you will find a list of rare diseases related to the PRLR. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
FAMILIAL HYPERPROLACTINEMIA
Alternate names
FAMILIAL HYPERPROLACTINEMIA Is also known as familial isolated prolactin receptor deficiency
Description
Familial hyperprolactinemia is a rare, genetic endocrine disorder characterized by persistently high prolactin serum levels (not associated with gestation, puerperium, drug intake or pituitary tumor) in multiple members of a family. Clinically it manifests with signs usually observed in hyperprolactinemia, which are: secondary medroxyprogesterone acetate (MPA)-negative amenorrhea and galactorrhea in female patients, and hypogonadism and decreased testosterone level-driven sexual dysfunction in male patients. Oligomenorrhea and primary infertility have also been reported in some female patients.
Most common symptoms of FAMILIAL HYPERPROLACTINEMIA
- Osteoporosis
- Hypogonadism
- Osteopenia
- Infertility
- Amenorrhea
More info about FAMILIAL HYPERPROLACTINEMIA
MULTIPLE FIBROADENOMA OF THE BREAST
Alternate names
MULTIPLE FIBROADENOMA OF THE BREAST Is also known as mammary polyadenomatosis
Description
Mammary polyadenomatosis is characterised by the presence in both breasts of multiple voluminous fibroadenomas with heterogeneous echo patterns.
More info about MULTIPLE FIBROADENOMA OF THE BREAST
Search interest in PRLR
Potential gene panels for PRLR gene
Female Infertility Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Female Infertility Sequencing Panel with CNV Detection that also includes the following genes: BMP15 SEMA3A SEMA3E FOXL2 SOX10 SOX2 SOX3 SOX9 SRA1 SRD5A2
More info about this panel United States.
Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection that also includes the following genes: ROR2 SALL1 BMP15 BMP4 SEMA3A SEMA3E BMP7 FOXL2 BRDT SOS1
More info about this panel United States.
PRLR Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the PRLR gene.
More info about this panel United States.
Tempus xO assay Panel
United States.
By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2
More info about this panel United States.
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