NGF gene related symptoms and diseases
All the information presented here about the NGF gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,HGNC,OMIM,ORPHANET, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to NGF gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Painless fractures due to injury | Very Common - Between 80% and 100% cases |
| Peripheral neuropathy | Very Common - Between 80% and 100% cases |
| Intellectual disability, mild | Very Common - Between 80% and 100% cases |
| Pain | Very Common - Between 80% and 100% cases |
| Hyperhidrosis | Very Common - Between 80% and 100% cases |
Other less frequent symptoms and clinical features
Patients with NGF gene alterations may also develop some of the following symptoms and phenotypes:Commonly - More than 50% cases
- Pain insensitivity
- Hypohidrosis
- Anhidrosis
Not very common - Between 30% and 50% cases
- Hepatic failure
- Muscle weakness
- Hepatomegaly
- Fever
- Areflexia
And 34 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to NGF gene
Here you will find a list of rare diseases related to the NGF. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY TYPE 5
Alternate names
HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY TYPE 5 Is also known as hsan v, insensitivity to pain, congenital, hsan5, congenital insensitivity to pain and thermal analgesia, hereditary sensory and autonomic neuropathy type v
Description
Hereditary sensory and autonomic neuropathy, type 5 (HSAN5) is characterized by loss of pain perception and impaired temperature sensitivity, in the absence of any other major neurological anomalies.
Most common symptoms of HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY TYPE 5
- Intellectual disability
- Pain
- Peripheral neuropathy
- Abnormality of the dentition
- Intellectual disability, mild
More info about HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY TYPE 5
INDIFFERENCE TO PAIN, CONGENITAL, AUTOSOMAL RECESSIVE; CIP
Alternate names
INDIFFERENCE TO PAIN, CONGENITAL, AUTOSOMAL RECESSIVE; CIP Is also known as congenital analgesia, autosomal recessive, insensitivity to pain, channelopathy-associated, asymbolia for pain
Description
Congenital indifference to pain is a rare autosomal recessive disorder characterized by the complete absence of pain perception typically associated with noxious stimuli. Affected individuals are aware of a stimulus, but have lost the ability to perceive pain. Most patients are hyposmic or anosmic. Other sensory modalities are unaffected, and there is an absence of overt autonomic symptoms. Sural nerve biopsy and nerve conduction velocity studies are normal (summary by Cox et al., 2006; and Goldberg et al., 2012).Hereditary sensory and autonomic neuropathy type IID (HSAN2D) is an autosomal recessive disorder characterized by congenital or childhood-onset distal loss of pain and temperature sensation as well as autonomic dysfunction accompanied by hyposmia, hearing loss, hypogeusia, and sometimes bone dysplasia. The phenotype is highly variable, even within families. Two Japanese families have been reported (summary by Yuan et al., 2013).For a discussion of genetic heterogeneity of HSAN, see HSAN1 (OMIM ).
Most common symptoms of INDIFFERENCE TO PAIN, CONGENITAL, AUTOSOMAL RECESSIVE; CIP
- Short stature
- Generalized hypotonia
- Hearing impairment
- Sensorineural hearing impairment
- Muscle weakness
More info about INDIFFERENCE TO PAIN, CONGENITAL, AUTOSOMAL RECESSIVE; CIP
SOURCES: OMIM
Search interest in NGF
Potential gene panels for NGF gene
Charcot-Marie-Tooth (CMT) and Related Hereditary Neuropathies, PMP22 Deletion/Duplication with Reflex to Sequencing Panel Panel
United States.
By ARUP Laboratories, Molecular Genetics and Genomics Charcot-Marie-Tooth (CMT) and Related Hereditary Neuropathies, PMP22 Deletion/Duplication with Reflex to Sequencing Panel that also includes the following genes: SBF1 SCN9A SLC12A6 SOX10 ATL1 SPTLC1 SPTLC2 TFG YARS PRX
More info about this panel United States.
Charcot-Marie-Tooth (CMT) and Related Hereditary Neuropathies Panel, Sequencing Panel
United States.
By ARUP Laboratories, Molecular Genetics and Genomics Charcot-Marie-Tooth (CMT) and Related Hereditary Neuropathies Panel, Sequencing that also includes the following genes: SBF1 SCN9A SLC12A6 SOX10 ATL1 SPTLC1 SPTLC2 TFG YARS PRX
More info about this panel United States.
NGF. Complete sequencing Panel
Spain.
By Instituto de Medicina Genomica Instituto de Medicina Genomica
This panel specifically test the NGF gene.
More info about this panel Spain.
Hereditary peripheral neuropathies, including Charcot-Marie-Tooth disease (NGS panel for 74 genes) Panel
Portugal.
By CGC Genetics Hereditary peripheral neuropathies, including Charcot-Marie-Tooth disease (NGS panel for 74 genes) that also includes the following genes: SBF1 SCN11A SCN9A DST SLC12A6 SOX10 ATL1 SPTLC1 SPTLC2 TWNK
More info about this panel Portugal.
Hereditary Sensory and Autonomic Neuropathy Type V (HSAN5) via NGF Gene Sequencing with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics
This panel specifically test the NGF gene.
More info about this panel United States.
Hereditary Sensory and Autonomic Neuropathy Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Hereditary Sensory and Autonomic Neuropathy Sequencing Panel with CNV Detection that also includes the following genes: SCN11A SCN9A DST ATL1 SPTLC1 SPTLC2 PRDM12 WNK1 CCT5 CLTCL1
More info about this panel United States.
Comprehensive Neuropathy Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Comprehensive Neuropathy Sequencing Panel with CNV Detection that also includes the following genes: SBF1 SCN9A SLC12A6 ATL1 SPTLC1 SPTLC2 TFG TTR YARS PRX
More info about this panel United States.
Neuropathy Panel
Germany.
By MGZ Medical Genetics Center Neuropathy that also includes the following genes: SACS SCN10A SCN11A SCN9A SH3BP4 SLC12A6 SOD1 SPG11 ATL1 SPAST
More info about this panel Germany.
Hereditary Sensory and Autonomic Neuropathy Type V Panel
Germany.
By MGZ Medical Genetics Center
This panel specifically test the NGF gene.
More info about this panel Germany.
HSAN5 Panel
Germany.
By Centogene AG - the Rare Disease Company
This panel specifically test the NGF gene.
More info about this panel Germany.
AllNeuro panel Panel
Germany.
By Centogene AG - the Rare Disease Company AllNeuro panel that also includes the following genes: BCS1L ROR2 RPL10 BDNF RPS6KA3 RTN2 RYR1 SACS BIN1 SBF1
More info about this panel Germany.
Neuropathy, hereditary sensory and autonomic, type V Panel
Germany.
By bio.logis Center for Human Genetics Diagnosticum
This panel specifically test the NGF gene.
More info about this panel Germany.
Charcot-Marie-Tooth and Sensory Neuropathies Panel Panel
Germany.
By CeGaT GmbH Charcot-Marie-Tooth and Sensory Neuropathies Panel that also includes the following genes: SBF1 SCN10A SCN11A SCN9A DST SLC12A6 SOX10 ATL1 SPTLC1 SPTLC2
More info about this panel Germany.
Single gene testing NGF Panel
Germany.
By CeGaT GmbH
This panel specifically test the NGF gene.
More info about this panel Germany.
NGF - Gene sequencing Panel
Netherlands.
By Clinical Genetics Academic Medical Center
This panel specifically test the NGF gene.
More info about this panel Netherlands.
Charcot-Marie-Tooth Disease Panel
Estonia.
By Asper Biogene Asper Biogene LLC Charcot-Marie-Tooth Disease that also includes the following genes: SBF1 SCN9A SPTLC1 SPTLC2 SURF1 TFG VCP YARS PRX SLC5A7
More info about this panel Estonia.
Neuropathy, hereditary sensory and autonomic V Panel
Austria.
By Praxis fuer Humangenetik Wien
This panel specifically test the NGF gene.
More info about this panel Austria.
Neuropathy, hereditary sensory and autonomic V Panel
Slovakia.
By MedGene
This panel specifically test the NGF gene.
More info about this panel Slovakia.
Invitae Comprehensive Neuropathies Panel Panel
United States.
By Invitae Invitae Comprehensive Neuropathies Panel that also includes the following genes: SCN11A SCN9A DST SPG11 ATL1 SPTLC1 SPTLC2 TFG TTR UBA1
More info about this panel United States.
Invitae Hereditary Sensory and Autonomic Neuropathy Panel Panel
United States.
By Invitae Invitae Hereditary Sensory and Autonomic Neuropathy Panel that also includes the following genes: SCN11A SCN9A DST ATL1 SPTLC1 SPTLC2 WNK1 ATL3 RETREG1 DNMT1
More info about this panel United States.
Hereditary Neuropathies: Sequencing Panel Panel
United States.
By EGL Genetic Diagnostics Eurofins Clinical Diagnostics Hereditary Neuropathies: Sequencing Panel that also includes the following genes: SACS SCN9A SLC12A6 SLC1A3 SPG11 ATL1 SPAST SPG7 SPTBN2 SPTLC1
More info about this panel United States.
Hereditary Neuropathies: Deletion/Duplication Panel Panel
United States.
By EGL Genetic Diagnostics Eurofins Clinical Diagnostics Hereditary Neuropathies: Deletion/Duplication Panel that also includes the following genes: SACS SCN9A SLC12A6 SLC1A3 SPG11 ATL1 SPAST SPG7 SPTBN2 SPTLC1
More info about this panel United States.
Intellectual Disability NGS Panel Panel
United States.
By Fulgent Genetics Fulgent Genetics Intellectual Disability NGS Panel that also includes the following genes: BCS1L RPS6KA3 SACS BIN1 SCN1A SCN8A SDCCAG8 SGCA SGSH ST3GAL3
More info about this panel United States.
Charcot Marie Tooth Disease Extended NGS Panel Panel
United States.
By Fulgent Genetics Fulgent Genetics Charcot Marie Tooth Disease Extended NGS Panel that also includes the following genes: SCN9A SLC12A6 ATL1 SPTLC1 SPTLC2 TTR PRX WNK1 BSCL2 GDAP1
More info about this panel United States.
NGF Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the NGF gene.
More info about this panel United States.
Charcot-Marie-Tooth Neuropathy Panel Panel
Finland.
By Blueprint Genetics Charcot-Marie-Tooth Neuropathy Panel that also includes the following genes: SACS SBF1 SCN11A SCN9A DST SLC12A6 SPG11 ATL1 SPTLC1 SPTLC2
More info about this panel Finland.
Neuropathy, hereditary sensory and autonomic, type V Panel
Spain.
By Bioarray
This panel specifically test the NGF gene.
More info about this panel Spain.
NEUROPATÍA HEREDITARIA SENSITIVO-AUTONÓMICA TIPO 5 Panel
Spain.
By Laboratorio de Genetica Clinica SL
This panel specifically test the NGF gene.
More info about this panel Spain.
Hereditary Sensory and Autonomous Neuropathy Type V , Sequencing NGF Gene Panel
Spain.
By Reference Laboratory Genetics
This panel specifically test the NGF gene.
More info about this panel Spain.
Tempus xO assay Panel
United States.
By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2
More info about this panel United States.
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