MKRN3 gene related symptoms and diseases
All the information presented here about the MKRN3 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,ORPHANET,OMIM,HGNC, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to MKRN3 gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Neoplasm | Uncommon - Between 30% and 50% cases |
| Obesity | Uncommon - Between 30% and 50% cases |
| Abnormality of the cardiovascular system | Uncommon - Between 30% and 50% cases |
| Type II diabetes mellitus | Uncommon - Between 30% and 50% cases |
| Accelerated skeletal maturation | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with MKRN3 gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Breast carcinoma
- Precocious puberty
- Premature thelarche
Rare diseases associated to MKRN3 gene
Here you will find a list of rare diseases related to the MKRN3. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
PRECOCIOUS PUBERTY, CENTRAL, 2; CPPB2
Description
Early activation of the hypothalamic-pituitary-gonadal axis results in gonadotropin-dependent precocious puberty, also known as central precocious puberty, which is clinically defined by the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Pubertal timing is influenced by complex interactions among genetic, nutritional, environmental, and socioeconomic factors. The timing of puberty is associated with risks of subsequent disease: earlier age of menarche in girls is associated with increased risk of breast cancer, endometrial cancer, obesity, type 2 diabetes, and cardiovascular disease. Central precocious puberty has also been associated with an increased incidence of conduct and behavior disorders during adolescence (summary by Abreu et al., 2013).For discussion of genetic heterogeneity of central precocious puberty, see CPPB1 (OMIM ).
Most common symptoms of PRECOCIOUS PUBERTY, CENTRAL, 2; CPPB2
- Neoplasm
- Obesity
- Abnormality of the cardiovascular system
- Type II diabetes mellitus
- Accelerated skeletal maturation
More info about PRECOCIOUS PUBERTY, CENTRAL, 2; CPPB2
SOURCES: OMIM
IDIOPATHIC CENTRAL PRECOCIOUS PUBERTY
Search interest in MKRN3
Potential gene panels for MKRN3 gene
MKRN3 Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the MKRN3 gene.
More info about this panel United States.
Abnormal Genitalia/ Disorders of Sex Development Panel Panel
Finland.
By Blueprint Genetics Abnormal Genitalia/ Disorders of Sex Development Panel that also includes the following genes: SOX9 SRD5A2 SRY STAR TACR3 CEP41 WT1 PROKR2 ZFPM2 FIG4
More info about this panel Finland.
Central Precocious Puberty NGS and Deletion/Duplication Panel Panel
United States.
By DDC Clinic Molecular Diagnostics Laboratory DDC Clinic, Center for Special Needs Children Central Precocious Puberty NGS and Deletion/Duplication Panel that also includes the following genes: KISS1R KISS1 LHCGR MKRN3
More info about this panel United States.
MKRN3 Gene Sequencing and Deletion/Duplication Analysis Panel
United States.
By DDC Clinic Molecular Diagnostics Laboratory DDC Clinic, Center for Special Needs Children
This panel specifically test the MKRN3 gene.
More info about this panel United States.
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