LHB gene related symptoms and diseases
All the information presented here about the LHB gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,OMIM,HGNC,NCBIGENE, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to LHB gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Abnormality of metabolism/homeostasis | Common - Between 50% and 80% cases |
| Enlarged ovaries | Common - Between 50% and 80% cases |
| Infertility | Common - Between 50% and 80% cases |
| Amenorrhea | Common - Between 50% and 80% cases |
| Oligomenorrhea | Common - Between 50% and 80% cases |
Other less frequent symptoms and clinical features
Patients with LHB gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Hypogonadotrophic hypogonadism
- Conjunctival hyperemia
- Beta-cell dysfunction
- Hypogonadism
- Micropenis
- Decreased testicular size
- Gynecomastia
- Hypergonadotropic hypogonadism
And 37 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to LHB gene
Here you will find a list of rare diseases related to the LHB. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
POLYCYSTIC OVARY SYNDROME 1; PCOS1
Alternate names
POLYCYSTIC OVARY SYNDROME 1; PCOS1 Is also known as pco, pco1, hyperandrogenemia, stein-leventhal syndrome, pcos
Description
a health problem that can affect a woman's menstrual cycle, fertility, hormones, insulin production, heart, blood vessels, and appearance
Most common symptoms of POLYCYSTIC OVARY SYNDROME 1; PCOS1
- Neoplasm
- Abnormality of metabolism/homeostasis
- Obesity
- Diabetes mellitus
- Apnea
More info about POLYCYSTIC OVARY SYNDROME 1; PCOS1
LEYDIG CELL HYPOPLASIA DUE TO LHB DEFICIENCY
Alternate names
LEYDIG CELL HYPOPLASIA DUE TO LHB DEFICIENCY Is also known as 46,xy dsd due to lhb deficiency, leydig cell hypoplasia due to luteinizing hormone subunit beta deficiency, 46,xy disorder of sex development due to lhb deficiency, 46,xy dsd due to luteinizing hormone subunit beta deficiency, 46,xy disorder of sex developmen
More info about LEYDIG CELL HYPOPLASIA DUE TO LHB DEFICIENCY
SOURCES: ORPHANET
HYPOGONADOTROPIC HYPOGONADISM 23 WITHOUT ANOSMIA; HH23
Alternate names
HYPOGONADOTROPIC HYPOGONADISM 23 WITHOUT ANOSMIA; HH23 Is also known as fertile eunuch syndrome, pasqualini syndrome
Description
Male patients with hypogonadotropic hypogonadism due to isolated luteinizing hormone (LH) deficiency have normal sexual differentiation but fail to develop spontaneous puberty. Absence of LH alters Leydig cell proliferation and maturation and impairs the onset of normal spermatogenesis, which requires high levels of intratesticular testosterone. Infertility and very low levels of spermatogenesis generally persist in affected men despite long-term exposure to gonadotropin therapy. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea (summary by Basciani et al., 2012).For a general phenotypic description and discussion of genetic heterogeneity of hypogonadotropic hypogonadism, see {147950}.
Most common symptoms of HYPOGONADOTROPIC HYPOGONADISM 23 WITHOUT ANOSMIA; HH23
- Abnormality of metabolism/homeostasis
- Hypogonadism
- Micropenis
- Infertility
- Decreased testicular size
More info about HYPOGONADOTROPIC HYPOGONADISM 23 WITHOUT ANOSMIA; HH23
SOURCES: OMIM
Search interest in LHB
Potential gene panels for LHB gene
Hypogonadotropic Hypogonadism Sequencing Panel Panel
United States.
By Genetic Services Laboratory University of Chicago Hypogonadotropic Hypogonadism Sequencing Panel that also includes the following genes: TAC3 TACR3 WDR11 PROKR2 IL17RD PROK2 CHD7 FEZF1 NSMF FGF17
More info about this panel United States.
Hypogonadotropic Hypogonadism Deletion/Duplication Panel Panel
United States.
By Genetic Services Laboratory University of Chicago Hypogonadotropic Hypogonadism Deletion/Duplication Panel that also includes the following genes: TAC3 TACR3 WDR11 PROKR2 IL17RD PROK2 CHD7 FEZF1 NSMF FGF17
More info about this panel United States.
Kallmann Syndrome Sequencing Panel Panel
United States.
By Genetic Services Laboratory University of Chicago Kallmann Syndrome Sequencing Panel that also includes the following genes: TAC3 TACR3 WDR11 PROKR2 IL17RD PROK2 CHD7 FEZF1 NSMF FGF17
More info about this panel United States.
Hypogonadism, hypergonadotropic (sequence analysis of LHB gene) Panel
Portugal.
By CGC Genetics
This panel specifically test the LHB gene.
More info about this panel Portugal.
Hypogonadism hypogonadotropic (NGS panel of 26 genes) Panel
Portugal.
By CGC Genetics Hypogonadism hypogonadotropic (NGS panel of 26 genes) that also includes the following genes: SEMA3A TAC3 TACR3 WDR11 SPRY4 PROKR2 IL17RD PROK2 CHD7 FEZF1
More info about this panel Portugal.
Hypogonadism hypogonadotropic (NGS panel of 26 genes) Panel
Portugal.
By CGC Genetics Hypogonadism hypogonadotropic (NGS panel of 26 genes) that also includes the following genes: SEMA3A TAC3 TACR3 WDR11 SPRY4 PROKR2 IL17RD PROK2 CHD7 FEZF1
More info about this panel Portugal.
Female Infertility Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Female Infertility Sequencing Panel with CNV Detection that also includes the following genes: BMP15 SEMA3A SEMA3E FOXL2 SOX10 SOX2 SOX3 SOX9 SRA1 SRD5A2
More info about this panel United States.
Male Infertility Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Male Infertility Sequencing Panel with CNV Detection that also includes the following genes: SEMA3A SEMA3E FOXL2 BRDT SOX10 SOX2 SOX3 SOX9 SRA1 SRD5A2
More info about this panel United States.
Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection that also includes the following genes: ROR2 SALL1 BMP15 BMP4 SEMA3A SEMA3E BMP7 FOXL2 BRDT SOS1
More info about this panel United States.
Disorders of Sex Development (DSD) Sequencing Panel with CNV Detection Panel
United States.
By PreventionGenetics PreventionGenetics Disorders of Sex Development (DSD) Sequencing Panel with CNV Detection that also includes the following genes: ROR2 SALL1 BMP15 BMP4 SEMA3A BMP7 FOXL2 SOS1 SOX10 SOX2
More info about this panel United States.
Infertility panel Panel
Germany.
By Centogene AG - the Rare Disease Company Infertility panel that also includes the following genes: FSHB FSHR LHB LHCGR
More info about this panel Germany.
LHB Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the LHB gene.
More info about this panel United States.
NORMOSMIC CONGENITAL HYPOGONADOTROPIC HYPOGONADISM Panel
Spain.
By Laboratorio de Genetica Clinica SL NORMOSMIC CONGENITAL HYPOGONADOTROPIC HYPOGONADISM that also includes the following genes: GNRHR KISS1R KISS1 LHB
More info about this panel Spain.
HYPOGONADOTROPIC HYPOGONADISM WITH ANOSMIA (KALLLMAN SYNDROME) NGS PANEL Panel
Spain.
By Laboratorio de Genetica Clinica SL HYPOGONADOTROPIC HYPOGONADISM WITH ANOSMIA (KALLLMAN SYNDROME) NGS PANEL that also includes the following genes: SEMA3A TAC3 TACR3 WDR11 SPRY4 PROKR2 IL17RD PROK2 CHD7 FEZF1
More info about this panel Spain.
Kallmann Syndrome , Panel Massive Sequencing (NGS) 20 Genes Panel
Spain.
By Reference Laboratory Genetics Kallmann Syndrome , Panel Massive Sequencing (NGS) 20 Genes that also includes the following genes: SEMA3A TAC3 TACR3 WDR11 PROKR2 PROK2 CHD7 NSMF POLR3B FGF8
More info about this panel Spain.
Female infertility genetic testing Panel
Canada.
By CEN4GEN Institute for Genomics and Molecular Diagnostics Female infertility genetic testing that also includes the following genes: BMP15 ZP1 FMR1 FSHR LHB LHCGR
More info about this panel Canada.
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