KRT10 gene related symptoms and diseases

All the information presented here about the KRT10 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,OMIM,NCBIGENE,HGNC, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to KRT10 gene

Symptoms // Phenotype % Cases
Erythroderma Common - Between 50% and 80% cases
Ichthyosis Common - Between 50% and 80% cases
Palmoplantar hyperkeratosis Common - Between 50% and 80% cases
Congenital ichthyosiform erythroderma Common - Between 50% and 80% cases
Erythema Common - Between 50% and 80% cases

Other less frequent symptoms and clinical features

Patients with KRT10 gene alterations may also develop some of the following symptoms and phenotypes:
  • Commonly - More than 50% cases

  • Hyperkeratosis
  • Not very common - Between 30% and 50% cases

  • Palmoplantar keratoderma
  • Congenital bullous ichthyosiform erythroderma
  • Scaling skin
  • Epidermal acanthosis
  • Rarely - Less than 30% cases

  • Disseminated intravascular coagulation
  • Generalized hyperkeratosis
  • Hypernatremia

And 24 more phenotypes, you can get all of them using our tools for rare diseases.

Rare diseases associated to KRT10 gene

Here you will find a list of rare diseases related to the KRT10. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


AUTOSOMAL DOMINANT EPIDERMOLYTIC ICHTHYOSIS

Alternate names

AUTOSOMAL DOMINANT EPIDERMOLYTIC ICHTHYOSIS Is also known as bullous congenital ichthyosiform erythroderma of brock, epidermolytic ichthyosis, bie, bullous congenital ichthyosiform erythroderma, ehk, bullous erythroderma ichthyosiformis congenita of brocq, bcie, bullous ichthyosiform erythroderma, ichthyosis hystrix brocq

Description

Epidermolytic ichthyosis (EI) is a rare keratinopathic ichthyosis (KPI; see this term), that is characterized by a blistering phenotype at birth which progressively becomes hyperkeratotic.

Most common symptoms of AUTOSOMAL DOMINANT EPIDERMOLYTIC ICHTHYOSIS

  • Growth delay
  • Hyperhidrosis
  • Hyperkeratosis
  • Weight loss
  • Erythema


More info about AUTOSOMAL DOMINANT EPIDERMOLYTIC ICHTHYOSIS

SOURCES: OMIM ORPHANET

CONGENITAL RETICULAR ICHTHYOSIFORM ERYTHRODERMA

Alternate names

CONGENITAL RETICULAR ICHTHYOSIFORM ERYTHRODERMA Is also known as iwc, crie, ichthyosis with confetti, ichthyosis variegata

Description

Congenital reticular ichthyosiform erythroderma (CRIE), also known as ichthyosis with confetti (IWC), is a rare skin condition characterized by slowly enlarging islands of normal skin surrounded by erythematous ichthyotic patches in a reticulated pattern. The condition starts in infancy as a lamellar ichthyosis, with small islands of normal skin resembling confetti appearing in late childhood and at puberty. Histopathologic findings include band-like parakeratosis, psoriasiform acanthosis, and vacuolization of keratinocytes with binucleated cells in the upper epidermis, sometimes associated with amyloid deposition in the dermis. Ultrastructural abnormalities include perinuclear shells formed from a network of fine filaments in the upper epidermis (summary by Krunic et al., 2003).

Most common symptoms of CONGENITAL RETICULAR ICHTHYOSIFORM ERYTHRODERMA

  • Hyperkeratosis
  • Erythema
  • Ichthyosis
  • Palmoplantar keratoderma
  • Epidermal acanthosis


More info about CONGENITAL RETICULAR ICHTHYOSIFORM ERYTHRODERMA

SOURCES: ORPHANET OMIM MESH

ANNULAR EPIDERMOLYTIC ICHTHYOSIS

Alternate names

ANNULAR EPIDERMOLYTIC ICHTHYOSIS Is also known as ciehk, epidermolytic ichthyosis, annular, aei

Description

Annular epidermolytic ichthyosis (AEI) is a rare clinical variant of epidermolytic ichthyosis (EI; see this term) characterized by the presence of a blistering phenotype at birth and the development from early infancy of annular polycyclic erythematous scales on the trunk and extremities.

Most common symptoms of ANNULAR EPIDERMOLYTIC ICHTHYOSIS

  • Hyperkeratosis
  • Erythema
  • Ichthyosis
  • Palmoplantar hyperkeratosis
  • Erythroderma


More info about ANNULAR EPIDERMOLYTIC ICHTHYOSIS

SOURCES: OMIM MESH ORPHANET

AUTOSOMAL RECESSIVE EPIDERMOLYTIC ICHTHYOSIS

Alternate names

AUTOSOMAL RECESSIVE EPIDERMOLYTIC ICHTHYOSIS Is also known as arei


More info about AUTOSOMAL RECESSIVE EPIDERMOLYTIC ICHTHYOSIS

SOURCES: ORPHANET


Potential gene panels for KRT10 gene

KRT10 Panel

Germany.

By Institute for Human Genetics University Clinic Freiburg

This panel specifically test the KRT10 gene.

More info about this panel
Germany.

KRT10. Complete sequencing Panel

Spain.

By Instituto de Medicina Genomica Instituto de Medicina Genomica

This panel specifically test the KRT10 gene.

More info about this panel
Spain.

Epidermolytic hyperkeratosis (sequence analysis of KRT10 gene) Panel

Portugal.

By CGC Genetics

This panel specifically test the KRT10 gene.

More info about this panel
Portugal.

Epidermolysis bullosa (NGS panel for 18 genes) Panel

Portugal.

By CGC Genetics Epidermolysis bullosa (NGS panel for 18 genes) that also includes the following genes: DST FERMT1 COL17A1 COL7A1 DSP EXPH5 ITGA3 ITGA6 ITGB4 KRT1

More info about this panel
Portugal.

Epidermolysis Bullosa and Related Disorders Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Epidermolysis Bullosa and Related Disorders Sequencing Panel with CNV Detection that also includes the following genes: DST TGM5 FERMT1 COL17A1 COL7A1 DSP ITGA3 ITGA6 ITGB4 JUP

More info about this panel
United States.

Congenital Ichthyosis and Related Disorders Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Congenital Ichthyosis and Related Disorders Sequencing Panel with CNV Detection that also includes the following genes: SLC27A4 ST14 TGM1 ALOXE3 ABCA12 CLDN1 POMP PNPLA1 ABHD5 LIPN

More info about this panel
United States.

Ichthyosis Deletion / Duplication panel Panel

United States.

By Connective Tissue Gene Tests Ichthyosis Deletion / Duplication panel that also includes the following genes: ST14 STS SULT2B1 TGM1 TGM5 ALOXE3 ABCA12 CASP14 CHST8 CDSN

More info about this panel
United States.

Ichthyosis NGS panel Panel

United States.

By Connective Tissue Gene Tests Ichthyosis NGS panel that also includes the following genes: ST14 STS SULT2B1 TGM1 TGM5 ALOXE3 ABCA12 CASP14 CHST8 CDSN

More info about this panel
United States.

Ichthyosis Comprehensive panel Panel

United States.

By Connective Tissue Gene Tests Ichthyosis Comprehensive panel that also includes the following genes: ST14 STS SULT2B1 TGM1 TGM5 ALOXE3 ABCA12 CASP14 CHST8 CDSN

More info about this panel
United States.

Epidermolytic hyperkeratosis Panel

Germany.

By Centogene AG - the Rare Disease Company

This panel specifically test the KRT10 gene.

More info about this panel
Germany.

Ichthyoses and related disorders of cornification Panel Panel

Germany.

By CeGaT GmbH Ichthyoses and related disorders of cornification Panel that also includes the following genes: SLC27A4 SNAP29 ST14 STS TAT TGM1 TGM5 VPS33B ATP2C1 NSDHL

More info about this panel
Germany.

Genetic Epidermolyses and blistering disorders Panel Panel

Germany.

By CeGaT GmbH Genetic Epidermolyses and blistering disorders Panel that also includes the following genes: DST FERMT1 COL17A1 COL7A1 DSP EXPH5 ITGA3 ITGA6 ITGB4 KRT1

More info about this panel
Germany.

KRT10 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the KRT10 gene.

More info about this panel
United States.

Ichthyosis Panel Panel

Finland.

By Blueprint Genetics Ichthyosis Panel that also includes the following genes: SLC27A4 STS TGM1 ALOXE3 ABCA12 MBTPS2 SPINK5 MPLKIP CDSN SUMF1

More info about this panel
Finland.

Bullous congenital ichthyosiform erythroderma Panel

Spain.

By Bioarray

This panel specifically test the KRT10 gene.

More info about this panel
Spain.

ICHTHYOSIFORM ERYTHRODERMA, BULLOUS CONGENITAL Panel

Spain.

By Laboratorio de Genetica Clinica SL ICHTHYOSIFORM ERYTHRODERMA, BULLOUS CONGENITAL that also includes the following genes: KRT1 KRT10

More info about this panel
Spain.

ICHTHYOSIS, EPIDERMOLYTIC Panel

Spain.

By Laboratorio de Genetica Clinica SL ICHTHYOSIS, EPIDERMOLYTIC that also includes the following genes: KRT1 KRT10

More info about this panel
Spain.

EPIDERMOLISIS BULLOSA: NGS PANEL Panel

Spain.

By Laboratorio de Genetica Clinica SL EPIDERMOLISIS BULLOSA: NGS PANEL that also includes the following genes: DST TGM5 FERMT1 COL17A1 COL7A1 KLHL24 DSP EXPH5 ITGA3 ITGA6

More info about this panel
Spain.

Congenital Ichthyosis and related disorders , Panel Massive Sequencing (NGS) 33 Genes Panel

Spain.

By Reference Laboratory Genetics Congenital Ichthyosis and related disorders , Panel Massive Sequencing (NGS) 33 Genes that also includes the following genes: SLC27A4 SNAP29 ST14 STS TGM1 TGM5 ALOXE3 ABCA12 SPINK5 MPLKIP

More info about this panel
Spain.

Palmoplantar Keratoderma and Related Disorders , Panel Massive Sequencing (NGS) 6 Genes Panel

Spain.

By Reference Laboratory Genetics Palmoplantar Keratoderma and Related Disorders , Panel Massive Sequencing (NGS) 6 Genes that also includes the following genes: TRPV3 AQP5 KRT1 KRT10 KRT16 KRT9

More info about this panel
Spain.

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