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  2. Rare Disease Genes
  3. KLHL10

KLHL10 gene related symptoms and diseases

All the information presented here about the KLHL10 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,HGNC,ORPHANET,OMIM, Mendelian Rare Disease Search Engine.

Table of contents:

Top 5 symptoms and clinical features associated to KLHL10 gene

Symptoms // Phenotype % Cases
Infertility Uncommon - Between 30% and 50% cases
Abnormal sperm morphology Uncommon - Between 30% and 50% cases
Decreased testicular size Uncommon - Between 30% and 50% cases
Azoospermia Uncommon - Between 30% and 50% cases
Increased circulating gonadotropin level Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with KLHL10 gene alterations may also develop some of the following symptoms and phenotypes:

  • Not very common - Between 30% and 50% cases

  • Abnormal spermatogenesis
  • Obstructive azoospermia
  • Non-obstructive azoospermia

Rare diseases associated to KLHL10 gene

Here you will find a list of rare diseases related to the KLHL10. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


SPERMATOGENIC FAILURE 11; SPGF11

Most common symptoms of SPERMATOGENIC FAILURE 11; SPGF11

  • Infertility
  • Abnormal sperm morphology


More info about SPERMATOGENIC FAILURE 11; SPGF11

SOURCES: OMIM

MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION

Description

Male infertility with azoospermia or oligospermia due to single gene mutation is a rare, genetic male infertility due to sperm disorder characterized by the absence of a measurable amount of spermatozoa in the ejaculate (azoospermia), or a number of sperm in the ejaculate inferior to 15 million/mL (oligozoospermia), resulting from a mutation in a single gene known to cause azoo- or oligo-spermia. Sperm morphology may be normal.

Most common symptoms of MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION

  • Decreased testicular size
  • Azoospermia
  • Increased circulating gonadotropin level
  • Abnormal spermatogenesis
  • Obstructive azoospermia


More info about MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION

SOURCES: ORPHANET


Potential gene panels for KLHL10 gene

Male Infertility Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Male Infertility Sequencing Panel with CNV Detection that also includes the following genes: SEMA3A SEMA3E FOXL2 BRDT SOX10 SOX2 SOX3 SOX9 SRA1 SRD5A2

More info about this panel
United States.

Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection Panel

United States.

By PreventionGenetics PreventionGenetics Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection that also includes the following genes: ROR2 SALL1 BMP15 BMP4 SEMA3A SEMA3E BMP7 FOXL2 BRDT SOS1

More info about this panel
United States.

KLHL10 Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the KLHL10 gene.

More info about this panel
United States.

Spermatogenic Failure , Panel Massive Sequencing (NGS) 9 Genes Panel

Spain.

By Reference Laboratory Genetics Spermatogenic Failure , Panel Massive Sequencing (NGS) 9 Genes that also includes the following genes: AURKC USP9Y CATSPER1 SYCP3 KLHL10 DPY19L2 SEPT12 SPATA16 NR5A1

More info about this panel
Spain.

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