ITGAM gene related symptoms and diseases
All the information presented here about the ITGAM gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,HGNC,ORPHANET,NCBIGENE, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to ITGAM gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Systemic lupus erythematosus | Common - Between 50% and 80% cases |
| Malar rash | Common - Between 50% and 80% cases |
| Pericarditis | Common - Between 50% and 80% cases |
| Pleuritis | Common - Between 50% and 80% cases |
| Antinuclear antibody positivity | Common - Between 50% and 80% cases |
Other less frequent symptoms and clinical features
Patients with ITGAM gene alterations may also develop some of the following symptoms and phenotypes:Commonly - More than 50% cases
- Cutaneous photosensitivity
- Arthritis
Not very common - Between 30% and 50% cases
- Leukemia
- Aseptic necrosis
- Increased antibody level in blood
- Abnormality of the thyroid gland
- Autoimmune hemolytic anemia
- Thyroiditis
And 35 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to ITGAM gene
Here you will find a list of rare diseases related to the ITGAM. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
ACUTE PROMYELOCYTIC LEUKEMIA
Alternate names
ACUTE PROMYELOCYTIC LEUKEMIA Is also known as acute myeloid leukemia with t(15;17)(q22;q12);(pml/raralpha) and variants, acute myeloblastic leukemia 3, apml, aml m3, aml with t(15;17)(q22;q12);(pml/raralpha) and variants, leukemia, acute promyelocytic
Description
Acute promyelocytic leukemia (APL) is an aggressive form of acute myeloid leukemia (AML; see this term), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells. APL manifests with easy bruising, hemorrhagic diathesis and fatigue.
Most common symptoms of ACUTE PROMYELOCYTIC LEUKEMIA
- Leukemia
- Acute promyelocytic leukemia
- Abnormal granulocytopoietic cell morphology
More info about ACUTE PROMYELOCYTIC LEUKEMIA
SYSTEMIC LUPUS ERYTHEMATOSUS
Alternate names
SYSTEMIC LUPUS ERYTHEMATOSUS Is also known as disseminated lupus erythematosus, sle
Description
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by Oishi et al., 2008).
Most common symptoms of SYSTEMIC LUPUS ERYTHEMATOSUS
- Seizures
- Short stature
- Cognitive impairment
- Anemia
- Fatigue
More info about SYSTEMIC LUPUS ERYTHEMATOSUS
SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 6; SLEB6
Most common symptoms of SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 6; SLEB6
- Arthritis
- Abnormality of the nervous system
- Cutaneous photosensitivity
- Spontaneous abortion
- Systemic lupus erythematosus
More info about SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 6; SLEB6
SOURCES: OMIM
Search interest in ITGAM
Potential gene panels for ITGAM gene
Systemic lupus erythematosus, susceptibility to Panel
Germany.
By Centogene AG - the Rare Disease Company
This panel specifically test the ITGAM gene.
More info about this panel Germany.
Neutrophil Antigen Genotyping Panel (includes HNA-1, 3, 4, 5) Panel
United States.
By BloodCenter of Wisconsin Diagnostic Laboratories BloodCenter of Wisconsin, part of Versiti Neutrophil Antigen Genotyping Panel (includes HNA-1, 3, 4, 5) that also includes the following genes: SLC44A2 CD177 FCGR3B ITGAL ITGAM
More info about this panel United States.
ITGAM Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the ITGAM gene.
More info about this panel United States.
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