IRF1 gene related symptoms and diseases
All the information presented here about the IRF1 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: HGNC,OMIM,NCBIGENE, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to IRF1 gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Neoplasm | Very Common - Between 80% and 100% cases |
| Carcinoma | Very Common - Between 80% and 100% cases |
| Neoplasm of the lung | Very Common - Between 80% and 100% cases |
| Respiratory distress | Uncommon - Between 30% and 50% cases |
| Small cell lung carcinoma | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with IRF1 gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Helicobacter pylori infection
- Neoplasm of the stomach
- Chronic atrophic gastritis
- Retinoblastoma
- Gastritis
- Stomach cancer
- Colon cancer
- Nephroblastoma
And 15 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to IRF1 gene
Here you will find a list of rare diseases related to the IRF1. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
LUNG CANCER
Description
Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. The 2 major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer (see {182280}), which account for 85% and 15% of all lung cancers, respectively. Nonsmall cell lung cancer can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. Cigarette smoking causes all types of lung cancer, but it is most strongly linked with small cell lung cancer and squamous cell carcinoma. Adenocarcinoma is the most common type in patients who have never smoked. Nonsmall cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis (summary by Herbst et al., 2008).
Most common symptoms of LUNG CANCER
- Neoplasm
- Pain
- Fatigue
- Respiratory distress
- Diarrhea
More info about LUNG CANCER
SOURCES: OMIM
GASTRIC CANCER
Description
In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several genes may be associated with an increased risk of gastric cancer.Gastric cancer is a manifestation of a number of inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (HNPCC1; see {120435}), familial adenomatous polyposis (FAP ), Peutz-Jeghers syndrome (PJS ), Cowden disease (CD ), and the Li-Fraumeni syndrome (OMIM ). See also hereditary diffuse gastric cancer (HDGC ).Canedo et al. (2007) provided a review of genetic susceptibility to gastric cancer in patients infected with Helicobacter pylori (see {600263}).
Most common symptoms of GASTRIC CANCER
- Neoplasm
- Carcinoma
- Nephroblastoma
- Colon cancer
- Neoplasm of the lung
More info about GASTRIC CANCER
Search interest in IRF1
Potential gene panels for IRF1 gene
IRF1 Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the IRF1 gene.
More info about this panel United States.
FoundationOne® Heme Panel
United States.
By Foundation Medicine, Inc. FoundationOne® Heme that also includes the following genes: BCL6 BCL7A ROS1 RUNX1 BLM SDHA SDHB SDHC SDHD SF3B1
More info about this panel United States.
Tempus xT assay Panel
United States.
By Tempus Labs, Inc. Tempus xT assay that also includes the following genes: BCL6 RIT1 BCL7A BCR ROS1 RPL5 RPS15 RPS6KB1 RUNX1 RXRA
More info about this panel United States.
If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like RNU4ATAC IL17RA ABCC6 BCORL1 ROBO3 MMAA ADK