GPR101 gene related symptoms and diseases
All the information presented here about the GPR101 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,ORPHANET,OMIM,HGNC, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to GPR101 gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Growth hormone excess | Very Common - Between 80% and 100% cases |
| Neoplasm | Common - Between 50% and 80% cases |
| Coarse facial features | Common - Between 50% and 80% cases |
| Sleep apnea | Common - Between 50% and 80% cases |
| Acanthosis nigricans | Common - Between 50% and 80% cases |
Other less frequent symptoms and clinical features
Patients with GPR101 gene alterations may also develop some of the following symptoms and phenotypes:Commonly - More than 50% cases
- Tall stature
- Large hands
- Pituitary adenoma
Not very common - Between 30% and 50% cases
- Precocious puberty
- Anterior hypopituitarism
- Spinal canal stenosis
- Palpebral edema
- Body odor
And 61 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to GPR101 gene
Here you will find a list of rare diseases related to the GPR101. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
ACROMEGALY
Description
Acromegaly is an acquired disorder related to excessive production of growth hormone (GH) and characterized by progressive somatic disfigurement (mainly involving the face and extremities) and systemic manifestations.
Most common symptoms of ACROMEGALY
- Neoplasm
- Hypertension
- Fatigue
- Frontal bossing
- Abnormality of the dentition
More info about ACROMEGALY
SOURCES: ORPHANET
X-LINKED ACROGIGANTISM DUE TO XQ26 MICRODUPLICATION
Alternate names
X-LINKED ACROGIGANTISM DUE TO XQ26 MICRODUPLICATION Is also known as x-linked acrogigantism, familial infantile gigantism due to xq26 microduplication, familial infantile gigantism due to dup(x)q(26), xlag, chromosome xq26 microduplication syndrome, x-lag (x-linked acrogigantism) due to dup(x)q(26)
Description
X-linked acrogigantism (XLAG), due to microduplications of chromosome Xq26.3, is characterized by excessive growth, usually beginning during the first year of life in previously normal infants. The overgrowth is caused by growth hormone (GH1 ) hypersecretion from pituitary hyperplasia and/or a pituitary macroadenoma. XLAG can occur as a sporadic condition or present as familial isolated pituitary adenomas (FIPAs) in acrogigantism kindreds (Beckers et al., 2015).
Most common symptoms of X-LINKED ACROGIGANTISM DUE TO XQ26 MICRODUPLICATION
- Neoplasm
- Coarse facial features
- Overgrowth
- Ventricular hypertrophy
- Tall stature
More info about X-LINKED ACROGIGANTISM DUE TO XQ26 MICRODUPLICATION
PITUITARY ADENOMA 2, GROWTH HORMONE-SECRETING; PITA2
Alternate names
PITUITARY ADENOMA 2, GROWTH HORMONE-SECRETING; PITA2 Is also known as acromegaly due to pituitary adenoma 2, acromegaly, x-linked
Most common symptoms of PITUITARY ADENOMA 2, GROWTH HORMONE-SECRETING; PITA2
- Growth hormone excess
- Pituitary adenoma
More info about PITUITARY ADENOMA 2, GROWTH HORMONE-SECRETING; PITA2
SOURCES: OMIM
Search interest in GPR101
Potential gene panels for GPR101 gene
Acromegaly, predisposition to, due to germline GPR101 mutation Panel
Germany.
By Centogene AG - the Rare Disease Company
This panel specifically test the GPR101 gene.
More info about this panel Germany.
GPR101 Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the GPR101 gene.
More info about this panel United States.
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