1. Mendelian
  2. Rare Disease Genes
  3. FCGR2B

FCGR2B gene related symptoms and diseases

All the information presented here about the FCGR2B gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: NCBIGENE,ORPHANET,HGNC,OMIM, Mendelian Rare Disease Search Engine.

Table of contents:

Top 5 symptoms and clinical features associated to FCGR2B gene

Symptoms // Phenotype % Cases
Cognitive impairment Very Common - Between 80% and 100% cases
Anemia Very Common - Between 80% and 100% cases
Thrombocytopenia Very Common - Between 80% and 100% cases
Seizures Uncommon - Between 30% and 50% cases
Fever Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with FCGR2B gene alterations may also develop some of the following symptoms and phenotypes:

  • Not very common - Between 30% and 50% cases

  • Epiphyseal stippling
  • Hashimoto thyroiditis
  • Gangrene
  • Raynaud phenomenon
  • Antinuclear antibody positivity
  • Pleuritis
  • Antiphospholipid antibody positivity
  • Complement deficiency

And 42 more phenotypes, you can get all of them using our tools for rare diseases.

Rare diseases associated to FCGR2B gene

Here you will find a list of rare diseases related to the FCGR2B. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


SYSTEMIC LUPUS ERYTHEMATOSUS

Alternate names

SYSTEMIC LUPUS ERYTHEMATOSUS Is also known as disseminated lupus erythematosus, sle

Description

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by production of autoantibodies against nuclear, cytoplasmic, and cell surface molecules that transcend organ-specific boundaries. Tissue deposition of antibodies or immune complexes induces inflammation and subsequent injury of multiple organs and finally results in clinical manifestations of SLE, including glomerulonephritis, dermatitis, thrombosis, vasculitis, seizures, and arthritis. Evidence strongly suggests the involvement of genetic components in SLE susceptibility (summary by Oishi et al., 2008). Genetic Heterogeneity of Systemic Lupus ErythematosusAn autosomal recessive form of systemic lupus erythematosus (SLEB16 ) is caused by mutation in the DNASE1L3 gene (OMIM ) on chromosome 3p14.3.See MAPPING and MOLECULAR GENETICS sections for a discussion of genetic heterogeneity of susceptibility to SLE.

Most common symptoms of SYSTEMIC LUPUS ERYTHEMATOSUS

  • Seizures
  • Short stature
  • Cognitive impairment
  • Anemia
  • Fatigue


More info about SYSTEMIC LUPUS ERYTHEMATOSUS

SOURCES: OMIM ORPHANET

MALARIA

Description

Malaria is a preventable life-threatening parasitic disease caused by Plasmodium (P. ) parasites that are transmitted by Anophles mosquito bites to humans and is typically clinically characterized by attacks of fever, headache, chills and vomiting.

Most common symptoms of MALARIA

  • Cognitive impairment
  • Anemia
  • Fever
  • Respiratory distress
  • Headache


More info about MALARIA

SOURCES: OMIM ORPHANET


Potential gene panels for FCGR2B gene

AllNeuro panel Panel

Germany.

By Centogene AG - the Rare Disease Company AllNeuro panel that also includes the following genes: BCS1L ROR2 RPL10 BDNF RPS6KA3 RTN2 RYR1 SACS BIN1 SBF1

More info about this panel
Germany.

Immune dysregulation Panel Panel

Germany.

By CeGaT GmbH Immune dysregulation Panel that also includes the following genes: SH2D1A STX11 STXBP2 FAS FASLG TREX1 ITCH CASP10 CASP8 CARD11

More info about this panel
Germany.

If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like ACACA MTHFD1 TBCK AFF4 CARD9 CARS2 WDR19