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  2. Rare Disease Genes
  3. DKK1

DKK1 gene related symptoms and diseases

All the information presented here about the DKK1 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: HGNC,NCBIGENE,OMIM,ORPHANET, Mendelian Rare Disease Search Engine.

Table of contents:

Top 5 symptoms and clinical features associated to DKK1 gene

Symptoms // Phenotype % Cases
Pain Very Common - Between 80% and 100% cases
Gait disturbance Very Common - Between 80% and 100% cases
Cervical C2/C3 vertebral fusion Uncommon - Between 30% and 50% cases
Basilar impression Uncommon - Between 30% and 50% cases
Central sleep apnea Uncommon - Between 30% and 50% cases

Other less frequent symptoms and clinical features

Patients with DKK1 gene alterations may also develop some of the following symptoms and phenotypes:

  • Not very common - Between 30% and 50% cases

  • Stiff neck
  • Dysesthesia
  • Myelopathy
  • Fused cervical vertebrae
  • Vocal cord paralysis
  • Arnold-Chiari type I malformation
  • Syringomyelia
  • Lower limb hyperreflexia

And 69 more phenotypes, you can get all of them using our tools for rare diseases.

Rare diseases associated to DKK1 gene

Here you will find a list of rare diseases related to the DKK1. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


IDIOPATHIC JUVENILE OSTEOPOROSIS

Alternate names

IDIOPATHIC JUVENILE OSTEOPOROSIS Is also known as idiopathic juvenile osteoporosis, juvenile osteoporosis, ijo

Description

Idiopathic juvenile osteoporosis (IJO) is a primary condition of bone demineralization that presents with pain in the back and extremities, walking difficulties, multiple fractures, and radiological evidence of osteoporosis.

Most common symptoms of IDIOPATHIC JUVENILE OSTEOPOROSIS

  • Pain
  • Gait disturbance
  • Kyphosis
  • Osteoporosis
  • Recurrent fractures


More info about IDIOPATHIC JUVENILE OSTEOPOROSIS

SOURCES: OMIM MESH ORPHANET

ARNOLD-CHIARI MALFORMATION TYPE I

Alternate names

ARNOLD-CHIARI MALFORMATION TYPE I Is also known as cm1, arnold-chiari malformation type 1, chiari malformation type 1, chiari malformation type i

Description

Arnold-Chiari malformation type I is a central nervous system malformation characterized by caudal displacement of the cerebellar tonsils exceeding 5mm below the foramen magnum with or without syringomyelia. Symptoms vary in onset and severity and include suboccipital headache, neck pain, vertigo, tinnitus, ocular symptoms (diplopia, blurred vision, photofobia, nystagmus), lower cranial nerve signs, cerebellar ataxia, and spasticity. Some affected individuals can be asymptomatic.

Most common symptoms of ARNOLD-CHIARI MALFORMATION TYPE I

  • Hearing impairment
  • Scoliosis
  • Ataxia
  • Nystagmus
  • Muscle weakness


More info about ARNOLD-CHIARI MALFORMATION TYPE I

SOURCES: OMIM ORPHANET



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