DGKE gene related symptoms and diseases
All the information presented here about the DGKE gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,HGNC,OMIM,NCBIGENE, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to DGKE gene
Symptoms // Phenotype | % Cases |
---|---|
Anemia | Uncommon - Between 30% and 50% cases |
Glomerulonephritis | Uncommon - Between 30% and 50% cases |
Microangiopathic hemolytic anemia | Uncommon - Between 30% and 50% cases |
Membranoproliferative glomerulonephritis | Uncommon - Between 30% and 50% cases |
Hemolytic-uremic syndrome | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with DGKE gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Microscopic hematuria
- Acute kidney injury
- Glomerulopathy
- Focal segmental glomerulosclerosis
- Glomerulosclerosis
- Hypertension
- Meningitis
- Nephrotic syndrome
And 6 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to DGKE gene
Here you will find a list of rare diseases related to the DGKE. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
IMMUNOGLOBULIN-MEDIATED MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS
Alternate names
IMMUNOGLOBULIN-MEDIATED MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS Is also known as ig-mediated mpgn, immunoglobulin-mediated mpgn, ig-mediated membranoproliferative glomerulonephritis, nephrotic syndrome, type 7, with membranoproliferative glomerulonephritis
Description
Nephrotic syndrome type 7 is an autosomal recessive renal disease characterized by onset of nephrotic syndrome with proteinuria usually in the first decade of life. The disorder is progressive, and some patients develop end-stage renal disease within several years. Renal biopsy typically shows membranoproliferative glomerulonephritis. Some patients may benefit from immunosuppressive therapy (summary by Ozaltin et al., 2013).Atypical hemolytic uremic syndrome-7 is characterized by acute onset in the first year of life of microangiopathic hemolytic anemia, thrombocytopenia, and renal failure. After the acute episode, most patients develop chronic renal insufficiency. Unlike other genetic forms of aHUS, AHUS7 is not related to abnormal activation of the complement system (summary by Lemaire et al., 2013).For a general phenotypic description and a discussion of genetic heterogeneity of nephrotic syndrome, see NPHS1 (OMIM ).For a general phenotypic description and a discussion of genetic heterogeneity of aHUS, see AHUS1 (OMIM ).
Most common symptoms of IMMUNOGLOBULIN-MEDIATED MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS
- Anemia
- Hypertension
- Renal insufficiency
- Thrombocytopenia
- Proteinuria
More info about IMMUNOGLOBULIN-MEDIATED MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS
ATYPICAL HEMOLYTIC-UREMIC SYNDROME WITH DGKE DEFICIENCY
Alternate names
ATYPICAL HEMOLYTIC-UREMIC SYNDROME WITH DGKE DEFICIENCY Is also known as d-hus with dgke deficiency, ahus with dgke deficiency, hemolytic-uremic syndrome without diarrhea with dgke deficiency, atypical hus with dgke deficiency
More info about ATYPICAL HEMOLYTIC-UREMIC SYNDROME WITH DGKE DEFICIENCY
SOURCES: ORPHANET
Search interest in DGKE
Potential gene panels for DGKE gene
Genetic Renal Panel Panel
By Molecular Otolaryngology and Renal Research Laboratories University of Iowa Hospital and Clinics Genetic Renal Panel that also includes the following genes: CFB THBD C3 ADAMTS13 CFHR3 MMACHC CFHR5 DGKE CFH CFHR1
More info about this panelAtypical Hemolytic Uremic Syndrome (aHUS) Genetic Susceptibility Panel Panel
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center Atypical Hemolytic Uremic Syndrome (aHUS) Genetic Susceptibility Panel that also includes the following genes: CFB THBD C3 CFHR3 CFHR5 DGKE CFH CFHR1 CFI CD46
More info about this panelDGKE Sequencing Panel
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center
This panel specifically test the DGKE gene.
More info about this panelDGKE Deletion/duplication analysis Panel
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center
This panel specifically test the DGKE gene.
More info about this panelaHUS Genetic Susceptibility Deletion/duplication panel Panel
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center aHUS Genetic Susceptibility Deletion/duplication panel that also includes the following genes: CFB THBD C3 DGKE CFI
More info about this panelThrombocytopenia Sequencing Panel Panel
By Genetic Services Laboratory University of Chicago Thrombocytopenia Sequencing Panel that also includes the following genes: CFB SRC TERC TERT THBD VWF WAS C3 ADAMTS13 ABCG5
More info about this panelThrombocytopenia Deletion/Duplication Panel Panel
By Genetic Services Laboratory University of Chicago Thrombocytopenia Deletion/Duplication Panel that also includes the following genes: CFB RUNX1 SRC TERC TERT THBD VWF WAS C3 ADAMTS13
More info about this panelExome PLUS Proteinuria/FSGS & Hematuria Panel
By Laboratory for Molecular Medicine Partners HealthCare Personalized Medicine Exome PLUS Proteinuria/FSGS & Hematuria that also includes the following genes: CFB TRPC6 TSC1 TSC2 C1QA C1QC WT1 C3 NPHS2 ADAMTS13
More info about this panelDGKE. Complete sequencing Panel
By Instituto de Medicina Genomica Instituto de Medicina Genomica
This panel specifically test the DGKE gene.
More info about this panelAtypical hemolytic uremic syndrome (NGS panel for 14 genes) Panel
By CGC Genetics Atypical hemolytic uremic syndrome (NGS panel for 14 genes) that also includes the following genes: CFB THBD C3 ADAMTS13 CFHR4 CFHR3 MMACHC CFHR5 DGKE CFH
More info about this panelAtypical hemolytic-uremic syndrome (sequence analysis of DGKE gene) Panel
By CGC Genetics
This panel specifically test the DGKE gene.
More info about this panelNephrotic syndrome (NGS panel for 11 genes) Panel
By CGC Genetics Nephrotic syndrome (NGS panel for 11 genes) that also includes the following genes: WT1 NPHS2 ACTN4 PLCE1 COQ8B DGKE EMP2 LAMB2 ARHGDIA NPHS1
More info about this panelAtypical hemolytic-uremic syndrome (deletions/duplications analysis of DGKE gene) Panel
By CGC Genetics
This panel specifically test the DGKE gene.
More info about this panelAtypical hemolytic-uremic syndrome (deletions/duplications analysis of DGKE gene) Panel
By CGC Genetics
This panel specifically test the DGKE gene.
More info about this panelNephrotic syndrome, type 7 Panel
By Laboratory for Molecular Diagnostics Center for Nephrology and Metabolic Disorders
This panel specifically test the DGKE gene.
More info about this panelNephrotic Syndrome (NS)/Focal Segmental Glomerulosclerosis (FSGS) Sequencing Panel with CNV Detection Panel
By PreventionGenetics PreventionGenetics Nephrotic Syndrome (NS)/Focal Segmental Glomerulosclerosis (FSGS) Sequencing Panel with CNV Detection that also includes the following genes: SGPL1 SMARCAL1 TRPC6 WT1 NPHS2 ANLN CD2AP TP53RK ACTN4 SCARB2
More info about this panelAtypical Hemolytic-Uremic Syndrome and Nephrotic Syndrome via DGKE Gene Sequencing with CNV Detection Panel
By PreventionGenetics PreventionGenetics
This panel specifically test the DGKE gene.
More info about this panelAtypical hemolytic uremic syndrome susceptibility and related disorders NGS panel Panel
By Connective Tissue Gene Tests Atypical hemolytic uremic syndrome susceptibility and related disorders NGS panel that also includes the following genes: CFB THBD C3 ADAMTS13 CFHR3 MMACHC CFHR5 DGKE CFH CFHR1
More info about this panelAtypical hemolytic uremic syndrome susceptibility and related disorders Deletion/ Duplication panel Panel
By Connective Tissue Gene Tests Atypical hemolytic uremic syndrome susceptibility and related disorders Deletion/ Duplication panel that also includes the following genes: CFB THBD C3 ADAMTS13 CFHR3 MMACHC CFHR5 DGKE CFH CFHR1
More info about this panelAtypical hemolytic uremic syndrome susceptibility and related disorders Comprehensive panel Panel
By Connective Tissue Gene Tests Atypical hemolytic uremic syndrome susceptibility and related disorders Comprehensive panel that also includes the following genes: CFB THBD C3 ADAMTS13 CFHR3 MMACHC CFHR5 DGKE CFH CFHR1
More info about this panelNephrotic syndrome and related disorders Comprehensive panel Panel
By Connective Tissue Gene Tests Nephrotic syndrome and related disorders Comprehensive panel that also includes the following genes: SGPL1 SMARCAL1 TRPC6 WT1 NPHS2 ANLN CD2AP ACTN4 SCARB2 PLCE1
More info about this panelNephrotic syndrome and related disorders NGS panel Panel
By Connective Tissue Gene Tests Nephrotic syndrome and related disorders NGS panel that also includes the following genes: SGPL1 SMARCAL1 TRPC6 WT1 NPHS2 ANLN CD2AP ACTN4 SCARB2 PLCE1
More info about this panelNephrotic syndrome and related disorders Deletion / Duplication panel Panel
By Connective Tissue Gene Tests Nephrotic syndrome and related disorders Deletion / Duplication panel that also includes the following genes: SGPL1 SMARCAL1 TRPC6 WT1 NPHS2 ANLN CD2AP ACTN4 SCARB2 PLCE1
More info about this panelAtypical hemolytic uremic syndrome Panel
By Northern Molecular Genetics Service Newcastle Upon Tyne Hospitals NHS Foundation Trust Atypical hemolytic uremic syndrome that also includes the following genes: CFB THBD C3 C5 ADAMTS13 INF2 MMACHC DGKE CFH CFI
More info about this panelNephrotic Syndrome Panel
By Institute of Human Genetics Uniklinik RWTH Aachen
This panel specifically test the DGKE gene.
More info about this panelAtypical hemolytic-uremic syndrome Panel
By Institute of Human Genetics Uniklinik RWTH Aachen Atypical hemolytic-uremic syndrome that also includes the following genes: CFB THBD C3 MMACHC DGKE CFH CFI CD46
More info about this panelHereditary kidney disorders - different panels Panel
By Institute of Human Genetics Uniklinik RWTH Aachen Hereditary kidney disorders - different panels that also includes the following genes: BCS1L ROBO2 CNNM2 CFB SALL1 ATXN10 SCNN1A SCNN1B SCNN1G SDCCAG8
More info about this panelNephrology Endocrinology and Electrolytes - panels Panel
By MGZ Medical Genetics Center Nephrology Endocrinology and Electrolytes - panels that also includes the following genes: ROBO2 SALL1 BLK BMP4 BMP7 SIX1 SIX2 SIX5 SLC12A1 SLC12A3
More info about this panelAtypical hemolytic uremic syndrome panel Panel
By Centogene AG - the Rare Disease Company Atypical hemolytic uremic syndrome panel that also includes the following genes: CFB THBD C3 ADAMTS13 CFHR4 CFHR3 CFHR5 DGKE CFH CFHR1
More info about this panelNephrotic syndrome panel Panel
By Centogene AG - the Rare Disease Company Nephrotic syndrome panel that also includes the following genes: WT1 NPHS2 PLCE1 DGKE LAMB2 ARHGDIA NPHS1
More info about this panelNephrotic syndrome 7 Panel
By Centogene AG - the Rare Disease Company
This panel specifically test the DGKE gene.
More info about this panelAtypical haemolytic uremic syndrome Panel
By Centogene AG - the Rare Disease Company
This panel specifically test the DGKE gene.
More info about this panelHemolytic Uremic Syndrome Panel Panel
By CeGaT GmbH Hemolytic Uremic Syndrome Panel that also includes the following genes: CFB THBD C3 ADAMTS13 CFHR4 CFHR3 CFHR5 DGKE CFH CFHR1
More info about this panelNephrotic Syndrome Panel Panel
By CeGaT GmbH Nephrotic Syndrome Panel that also includes the following genes: SMARCAL1 WT1 NPHS2 PLCE1 COQ8B COQ2 WDR73 DGKE EMP2 ITGA3
More info about this panelSingle gene testing DGKE Panel
By CeGaT GmbH
This panel specifically test the DGKE gene.
More info about this panelComplement deficiencies Panel Panel
By CeGaT GmbH Complement deficiencies Panel that also includes the following genes: CFB THBD SERPING1 C1QA C1QB C1QC C1R C1S C2 C3
More info about this panelTest for DGKE-Related Atypical Hemolytic Uremic Syndrome Panel
By Secugen SL
This panel specifically test the DGKE gene.
More info about this panelaHUS/DDD Genetic Evaluation Panel
By BloodCenter of Wisconsin Diagnostic Laboratories BloodCenter of Wisconsin, part of Versiti aHUS/DDD Genetic Evaluation that also includes the following genes: CFB THBD C3 C4BPA C4BPB ADAMTS13 CFHR4 CFHR3 CFHR5 DGKE
More info about this panelaCGH Deletion/Duplication Analysis Panel
By BloodCenter of Wisconsin Diagnostic Laboratories BloodCenter of Wisconsin, part of Versiti aCGH Deletion/Duplication Analysis that also includes the following genes: CFB RUNX1 STXBP2 TBXA2R THBD VWF WAS C3 C4BPA C4BPB
More info about this panelDGKE Panel
By Fulgent Genetics Fulgent Genetics
This panel specifically test the DGKE gene.
More info about this panelKidneySeq - 264 Genes Panel
By Iowa Institute of Human Genetics University of Iowa KidneySeq - 264 Genes that also includes the following genes: ROBO2 CNNM2 SALL1 ATXN10 SCNN1A SCNN1B SCNN1G SDCCAG8 BMP4 SEMA3E
More info about this panelNephrotic Syndrome Panel Panel
By Blueprint Genetics Nephrotic Syndrome Panel that also includes the following genes: SGPL1 SMARCAL1 TRPC6 WT1 NPHS2 ANLN CD2AP ACTN4 SCARB2 PLCE1
More info about this panelPrimary Immunodeficiency Panel Panel
By Blueprint Genetics Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC CFB BLM SH2D1A SLC7A7 SMARCAL1 SMARCD2 SRP72 BTK
More info about this panelComplement System Disorder Panel Panel
By Blueprint Genetics Complement System Disorder Panel that also includes the following genes: CFB SPAG1 THBD SERPING1 RSPH1 C1QA C1QB C1QBP C1QC C1S
More info about this panelHemolytic Uremic Syndrome Panel Panel
By Blueprint Genetics Hemolytic Uremic Syndrome Panel that also includes the following genes: CFB THBD C3 ADAMTS13 CFHR5 DGKE CFH CFI CD46
More info about this panelaHUS/TMA/C3 Glomerulopathy Gene Set Panel
By Genomics and Pathology Services Washington University in St. Louis aHUS/TMA/C3 Glomerulopathy Gene Set that also includes the following genes: CFB THBD C3 ADAMTS13 CFHR4 CFHR3 CFHR5 DGKE CFH CFHR1
More info about this panelSYNDROME WITH FOCAL SEGMENTAL GLOMERULOSCLEROSIS NGS PANEL Panel
By Laboratorio de Genetica Clinica SL SYNDROME WITH FOCAL SEGMENTAL GLOMERULOSCLEROSIS NGS PANEL that also includes the following genes: SGPL1 TRPC6 WT1 NPHS2 ANLN CD2AP ACTN4 PLCE1 NUP205 CRB2
More info about this panelATYPICAL HEMOLYTIC UREMIC SYNDROME Panel
By Laboratorio de Genetica Clinica SL ATYPICAL HEMOLYTIC UREMIC SYNDROME that also includes the following genes: CFB THBD C3 DGKE CFH CFI CD46
More info about this panelATYPICAL HEMOLYTIC UREMIC SYNDROME: NGS PANEL Panel
By Laboratorio de Genetica Clinica SL ATYPICAL HEMOLYTIC UREMIC SYNDROME: NGS PANEL that also includes the following genes: CFB THBD C1S C2 C3 C3AR1 C8A C9 CFHR4 CFHR3
More info about this panelCongenital Nephrotic Syndrome Type 7 , Sequencing DGKE Gene Panel
By Reference Laboratory Genetics
This panel specifically test the DGKE gene.
More info about this panelComplement System (Genetic Study) , Panel Massive Sequencing (NGS) 12 Genes Panel
By Reference Laboratory Genetics Complement System (Genetic Study) , Panel Massive Sequencing (NGS) 12 Genes that also includes the following genes: CFB THBD C3 ADAMTS13 CFHR3 CFHR5 DGKE CFH CFHR1 CFI
More info about this panelIf you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like AMER1 HADHA DBH CSMD2 QARS RREB1 MMAA