CD59 gene related symptoms and diseases
All the information presented here about the CD59 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: ORPHANET,HGNC,OMIM,NCBIGENE, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to CD59 gene
Symptoms // Phenotype | % Cases |
---|---|
Generalized hypotonia | Very Common - Between 80% and 100% cases |
Limb muscle weakness | Very Common - Between 80% and 100% cases |
Hemoglobinuria | Very Common - Between 80% and 100% cases |
Hemolytic-uremic syndrome | Very Common - Between 80% and 100% cases |
Increased CSF protein | Very Common - Between 80% and 100% cases |
Other less frequent symptoms and clinical features
Patients with CD59 gene alterations may also develop some of the following symptoms and phenotypes:Commonly - More than 50% cases
- Peripheral demyelination
- Polyneuropathy
- Hematuria
- Hemolytic anemia
- Paralysis
- Muscle weakness
- Pallor
- Respiratory failure
And 6 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to CD59 gene
Here you will find a list of rare diseases related to the CD59. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
PRIMARY CD59 DEFICIENCY
Alternate names
PRIMARY CD59 DEFICIENCY Is also known as cd59 deficiency
Description
Primary CD59 deficiency is a rare, genetic, hematologic and neurologic disease characterized by chronic, Coombs-negative hemolysis associated with early-onset, relapsing, immune-mediated, inflammatory, axonal or demyelinating, sensory-motor, peripheral polyneuropathy and isolated or recurrent cerebrovascular events (in anterior or posterior circulation).
Most common symptoms of PRIMARY CD59 DEFICIENCY
- Generalized hypotonia
- Muscle weakness
- Anemia
- Skeletal muscle atrophy
- Respiratory insufficiency
More info about PRIMARY CD59 DEFICIENCY
Search interest in CD59
Potential gene panels for CD59 gene
Hemolytic anemia, CD59-mediated, with or without immune-mediated polyneuropathy Panel
By Centogene AG - the Rare Disease Company
This panel specifically test the CD59 gene.
More info about this panelHemolytic anemia, CD59-mediated, with or without immune-mediated polyneuropathy Panel
By Centogene AG - the Rare Disease Company
This panel specifically test the CD59 gene.
More info about this panelAllNeuro panel Panel
By Centogene AG - the Rare Disease Company AllNeuro panel that also includes the following genes: BCS1L ROR2 RPL10 BDNF RPS6KA3 RTN2 RYR1 SACS BIN1 SBF1
More info about this panelComplement deficiencies Panel Panel
By CeGaT GmbH Complement deficiencies Panel that also includes the following genes: CFB THBD SERPING1 C1QA C1QB C1QC C1R C1S C2 C3
More info about this panelHereditary Hemolytic Anemia Comprehensive Sequencing, Varies Panel
By Mayo Clinic Genetic Testing Laboratories Mayo Clinic Hereditary Hemolytic Anemia Comprehensive Sequencing, Varies that also includes the following genes: RHAG RPS19 SEC23B SLC2A1 SPTA1 SPTB TPI1 UGT1A1 XK CD59
More info about this panelCD59 Panel
By Fulgent Genetics Fulgent Genetics
This panel specifically test the CD59 gene.
More info about this panelPrimary Immunodeficiency Panel Panel
By Blueprint Genetics Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC CFB BLM SH2D1A SLC7A7 SMARCAL1 SMARCD2 SRP72 BTK
More info about this panelComplement System Disorder Panel Panel
By Blueprint Genetics Complement System Disorder Panel that also includes the following genes: CFB SPAG1 THBD SERPING1 RSPH1 C1QA C1QB C1QBP C1QC C1S
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