CD55 gene related symptoms and diseases
All the information presented here about the CD55 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,HGNC,NCBIGENE, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to CD55 gene
| Symptoms // Phenotype | % Cases |
|---|---|
| Abnormal intestine morphology | Very Common - Between 80% and 100% cases |
| Protein-losing enteropathy | Very Common - Between 80% and 100% cases |
| Growth delay | Uncommon - Between 30% and 50% cases |
| Malnutrition | Uncommon - Between 30% and 50% cases |
| Neoplasm | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with CD55 gene alterations may also develop some of the following symptoms and phenotypes:Not very common - Between 30% and 50% cases
- Hypoproteinemic edema
- Hepatic vein thrombosis
- Budd-Chiari syndrome
- Intestinal lymphangiectasia
- Generalized edema
- Hypoproteinemia
- Hypercoagulability
- Thrombocytosis
And 20 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to CD55 gene
Here you will find a list of rare diseases related to the CD55. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
COMPLEMENT HYPERACTIVATION, ANGIOPATHIC THROMBOSIS, AND PROTEIN-LOSING ENTEROPATHY; CHAPLE
Description
Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy is characterized by abdominal pain and diarrhea, primary intestinal lymphangiectasia, hypoproteinemic edema, and malabsorption. Some patients also exhibit bowel inflammation, recurrent infections associated with hypogammaglobulinemia, and/or angiopathic thromboembolic disease. Patient T lymphocytes show increased complement activation, causing surface deposition of complement and generating soluble C5a (Ozen et al., 2017).
Most common symptoms of COMPLEMENT HYPERACTIVATION, ANGIOPATHIC THROMBOSIS, AND PROTEIN-LOSING ENTEROPATHY; CHAPLE
- Growth delay
- Pain
- Anemia
- Hepatomegaly
- Edema
More info about COMPLEMENT HYPERACTIVATION, ANGIOPATHIC THROMBOSIS, AND PROTEIN-LOSING ENTEROPATHY; CHAPLE
BLOOD GROUP, CROMER SYSTEM; CROM
Alternate names
BLOOD GROUP, CROMER SYSTEM; CROM Is also known as cromer blood group system
Description
The Cromer blood group system (CROM) consists of 12 high-prevalence and 3 low-prevalence antigens that reside on decay-accelerating factor (DAF, or CD55; {125240}), a regulator of complement activation. Nearly all Cromer antigens result from SNPs in the DAF gene. The red blood cells (RBCs) of people with the Cromer-null phenotype, Inab, lack DAF but do not appear to show increased susceptibility to hemolysis. Antibodies to Cromer antigens are rarely encountered, although evidence suggests that the antibodies may cause accelerated destruction of transfused RBCs. Cromer system antibodies are not associated with hemolytic disease of the newborn, because placenta is a rich source of fetally derived DAF, which is thought to absorb the antibodies (review by Storry et al., 2010).The Inab phenotype is associated with CHAPLE syndrome (OMIM ) in some individuals.
Most common symptoms of BLOOD GROUP, CROMER SYSTEM; CROM
- Neoplasm
- Carcinoma
- Abnormal intestine morphology
- Protein-losing enteropathy
More info about BLOOD GROUP, CROMER SYSTEM; CROM
SOURCES: OMIM
Search interest in CD55
Potential gene panels for CD55 gene
CD55 Panel
United States.
By Fulgent Genetics Fulgent Genetics
This panel specifically test the CD55 gene.
More info about this panel United States.
Primary Immunodeficiency Panel Panel
Finland.
By Blueprint Genetics Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC CFB BLM SH2D1A SLC7A7 SMARCAL1 SMARCD2 SRP72 BTK
More info about this panel Finland.
Complement System Disorder Panel Panel
Finland.
By Blueprint Genetics Complement System Disorder Panel that also includes the following genes: CFB SPAG1 THBD SERPING1 RSPH1 C1QA C1QB C1QBP C1QC C1S
More info about this panel Finland.
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