CAST gene related symptoms and diseases

All the information presented here about the CAST gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: OMIM,NCBIGENE,HGNC,ORPHANET, Mendelian Rare Disease Search Engine.

Top 5 symptoms and clinical features associated to CAST gene

Symptoms // Phenotype % Cases
Hyperkeratosis Very Common - Between 80% and 100% cases
Erythema Very Common - Between 80% and 100% cases
Scarring Very Common - Between 80% and 100% cases
Papule Very Common - Between 80% and 100% cases
Palmoplantar keratoderma Very Common - Between 80% and 100% cases

Other less frequent symptoms and clinical features

Patients with CAST gene alterations may also develop some of the following symptoms and phenotypes:
  • Commonly - More than 50% cases

  • Epidermal acanthosis
  • Scaling skin
  • Fragile skin
  • Oral leukoplakia
  • Onycholysis
  • Leukonychia
  • Cheilitis
  • Acantholysis

And 2 more phenotypes, you can get all of them using our tools for rare diseases.

Rare diseases associated to CAST gene

Here you will find a list of rare diseases related to the CAST. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


PEELING SKIN-LEUKONYCHIA-ACRAL PUNCTATE KERATOSES-CHEILITIS-KNUCKLE PADS SYNDROME

Alternate names

PEELING SKIN-LEUKONYCHIA-ACRAL PUNCTATE KERATOSES-CHEILITIS-KNUCKLE PADS SYNDROME Is also known as plack syndrome

Most common symptoms of PEELING SKIN-LEUKONYCHIA-ACRAL PUNCTATE KERATOSES-CHEILITIS-KNUCKLE PADS SYNDROME

  • Hyperkeratosis
  • Erythema
  • Scarring
  • Papule
  • Palmoplantar keratoderma


More info about PEELING SKIN-LEUKONYCHIA-ACRAL PUNCTATE KERATOSES-CHEILITIS-KNUCKLE PADS SYNDROME

SOURCES: ORPHANET OMIM


Potential gene panels for CAST gene

CAST Panel

Germany.

By Institute for Human Genetics University Clinic Freiburg

This panel specifically test the CAST gene.

More info about this panel
Germany.

Peeling skin syndrome NGS panel Panel

United States.

By Connective Tissue Gene Tests Peeling skin syndrome NGS panel that also includes the following genes: TGM5 CAST CHST8 CDSN CSTA FLG2 SERPINB8

More info about this panel
United States.

Peeling skin syndrome Comprehensive panel Panel

United States.

By Connective Tissue Gene Tests Peeling skin syndrome Comprehensive panel that also includes the following genes: TGM5 CAST CHST8 CDSN CSTA FLG2 SERPINB8

More info about this panel
United States.

Peeling skin syndrome Deletion / Duplication panel Panel

United States.

By Connective Tissue Gene Tests Peeling skin syndrome Deletion / Duplication panel that also includes the following genes: TGM5 CAST CHST8 CDSN CSTA FLG2 SERPINB8

More info about this panel
United States.

CAST Panel

United States.

By Fulgent Genetics Fulgent Genetics

This panel specifically test the CAST gene.

More info about this panel
United States.

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