CASP8 gene related symptoms and diseases
All the information presented here about the CASP8 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: HGNC,NCBIGENE,ORPHANET,OMIM, Mendelian Rare Disease Search Engine.
Top 5 symptoms and clinical features associated to CASP8 gene
Symptoms // Phenotype | % Cases |
---|---|
Carcinoma | Common - Between 50% and 80% cases |
Neoplasm | Common - Between 50% and 80% cases |
Fatigue | Uncommon - Between 30% and 50% cases |
Sarcoma | Uncommon - Between 30% and 50% cases |
Pain | Uncommon - Between 30% and 50% cases |
Other less frequent symptoms and clinical features
Patients with CASP8 gene alterations may also develop some of the following symptoms and phenotypes:Rarely - Less than 30% cases
- Hepatic necrosis
- Viral hepatitis
- Subacute progressive viral hepatitis
- Portal vein thrombosis
- Respiratory distress
- Diarrhea
- Weight loss
- Cough
And 55 more phenotypes, you can get all of them using our tools for rare diseases.
Rare diseases associated to CASP8 gene
Here you will find a list of rare diseases related to the CASP8. You can also use our tool to get a more accurate diagnosis based on your current symptoms.
AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME WITH RECURRENT VIRAL INFECTIONS
Alternate names
AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME WITH RECURRENT VIRAL INFECTIONS Is also known as caspase 8 deficiency syndrome, autoimmune lymphoproliferative syndrome, type iib, alps2b, ceds, alps with recurrent viral infections
Description
Autoimmune lymphoproliferative syndrome (ALPS) with recurrent viral infections is a rare genetic disorder characterized by lymphadenopathy and/or splenomegaly and recurrent infections due to herpes viruses.
Most common symptoms of AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME WITH RECURRENT VIRAL INFECTIONS
- Short stature
- Failure to thrive
- Splenomegaly
- Immunodeficiency
- Pneumonia
More info about AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME WITH RECURRENT VIRAL INFECTIONS
PEDIATRIC HEPATOCELLULAR CARCINOMA
Alternate names
PEDIATRIC HEPATOCELLULAR CARCINOMA Is also known as liver cancer, lcc, childhood-onset hcc, hcc, liver cell carcinoma, hepatoma, cancer, hepatocellular, childhood-onset hepatocellular carcinoma, pediatric hcc
Description
Pediatric hepatocellular carcinoma (pediatric HCC) is a rare, aggressive, malignant hepatic tumor that develops mainly in children over 10 years of age.
Most common symptoms of PEDIATRIC HEPATOCELLULAR CARCINOMA
- Microcephaly
- Neoplasm
- Cryptorchidism
- Motor delay
- Hepatomegaly
More info about PEDIATRIC HEPATOCELLULAR CARCINOMA
LUNG CANCER
Description
Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. The 2 major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer (see {182280}), which account for 85% and 15% of all lung cancers, respectively. Nonsmall cell lung cancer can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. Cigarette smoking causes all types of lung cancer, but it is most strongly linked with small cell lung cancer and squamous cell carcinoma. Adenocarcinoma is the most common type in patients who have never smoked. Nonsmall cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis (summary by Herbst et al., 2008).
Most common symptoms of LUNG CANCER
- Neoplasm
- Pain
- Fatigue
- Respiratory distress
- Diarrhea
More info about LUNG CANCER
SOURCES: OMIM
BREAST CANCER
Alternate names
BREAST CANCER Is also known as breast cancer, familial
Description
Breast cancer (referring to mammary carcinoma, not mammary sarcoma) is histopathologically and almost certainly etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement.
Most common symptoms of BREAST CANCER
- Neoplasm
- Pain
- Carcinoma
- Gynecomastia
- Breast carcinoma
More info about BREAST CANCER
ADULT HEPATOCELLULAR CARCINOMA
Alternate names
ADULT HEPATOCELLULAR CARCINOMA Is also known as adult hcc
Description
Adult hepatocellular carcinoma is the most common primary liver cancer of adulthood. Derived from well-differentiated hepatocytes, it often develops from chronic liver cirrhosis which is most often due to hepatitis B and C virus or alcohol abuse. Symptoms are hepatic mass, abdominal pain and, in advanced stages, jaundice, cachexia and liver failure.
More info about ADULT HEPATOCELLULAR CARCINOMA
SOURCES: ORPHANET
Search interest in CASP8
Potential gene panels for CASP8 gene
MitoMet®Plus aCGH Analysis Panel
By Baylor Miraca Genetics Laboratories MitoMet®Plus aCGH Analysis that also includes the following genes: RGS9 RHO GRK1 RLBP1 RNASEL BCS1L RP1 RP2 RP9 RPE65
More info about this panelAutoimmune Lymphoproliferative Syndrome Panel by next-generation sequencing (NGS) Panel
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center Autoimmune Lymphoproliferative Syndrome Panel by next-generation sequencing (NGS) that also includes the following genes: FAS FASLG CASP10 CASP8 MAGT1 FADD ITK KRAS NRAS
More info about this panelAutoimmune Lymphoproliferative Syndrome Deletion/Duplication Panel Panel
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center Autoimmune Lymphoproliferative Syndrome Deletion/Duplication Panel that also includes the following genes: FAS FASLG CASP10 CASP8 MAGT1 FADD ITK KRAS NRAS
More info about this panelCASP8 Sequencing Panel
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center
This panel specifically test the CASP8 gene.
More info about this panelCASP8 Deletion/duplication analysis Panel
By Cincinnati Children's Hospital Medical Center Laboratory of Genetics and Genomics Cincinnati Children's Hospital Medical Center
This panel specifically test the CASP8 gene.
More info about this panelCASP8. Complete sequencing Panel
By Instituto de Medicina Genomica Instituto de Medicina Genomica
This panel specifically test the CASP8 gene.
More info about this panelBreast cancer (sequence analysis of CASP8 gene) Panel
By CGC Genetics
This panel specifically test the CASP8 gene.
More info about this panelAutoimmune Lymphoproliferative Syndrome/ALPS Sequencing Panel with CNV Detection Panel
By PreventionGenetics PreventionGenetics Autoimmune Lymphoproliferative Syndrome/ALPS Sequencing Panel with CNV Detection that also includes the following genes: SH2D1A STAT3 FAS FASLG CASP10 CASP8 LRBA CTLA4 MAGT1 FADD
More info about this panelALPS/autoimmunity panel Panel
By Genome Diagnostics Laboratory University Medical Center Utrecht ALPS/autoimmunity panel that also includes the following genes: FAS FASLG ITCH CASP10 CASP8 LRBA FADD AIRE IL2RA FOXP3
More info about this panelAutoimmune lymphoproliferative syndrome Panel
By Centogene AG - the Rare Disease Company
This panel specifically test the CASP8 gene.
More info about this panelImmune dysregulation Panel Panel
By CeGaT GmbH Immune dysregulation Panel that also includes the following genes: SH2D1A STX11 STXBP2 FAS FASLG TREX1 ITCH CASP10 CASP8 CARD11
More info about this panelInvitae Monogenic Autoimmunity Panel Panel
By Invitae Invitae Monogenic Autoimmunity Panel that also includes the following genes: RMRP SH2D1A SLC7A7 BTK STAT1 STAT3 STAT5B STIM1 STX11 STXBP2
More info about this panelInvitae Primary Immunodeficiency Panel Panel
By Invitae Invitae Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC SEMA3E SH2D1A SH3BP2 SLC7A7 SMARCAL1 BTK STAT1 STAT2
More info about this panelInvitae Autoimmune Lymphoproliferative Disorders (ALPS) Panel Panel
By Invitae Invitae Autoimmune Lymphoproliferative Disorders (ALPS) Panel that also includes the following genes: FAS FASLG CASP8 CTLA4 MAGT1 ITK PIK3CD PRKCD
More info about this panelNuclear-Mito NGS Panel Panel
By Fulgent Genetics Fulgent Genetics Nuclear-Mito NGS Panel that also includes the following genes: RNASEL BCS1L RPL35A MRPL3 RYR1 RYR2 SACS ACSM3 SARDH ATXN7
More info about this panelCASP8 Panel
By Fulgent Genetics Fulgent Genetics
This panel specifically test the CASP8 gene.
More info about this panelPrimary Immunodeficiency Panel Panel
By Blueprint Genetics Primary Immunodeficiency Panel that also includes the following genes: RMRP RORC CFB BLM SH2D1A SLC7A7 SMARCAL1 SMARCD2 SRP72 BTK
More info about this panelCaris MI TumorSeek 592-Gene NGS Panel Panel
By Caris Life Sciences Caris MI TumorSeek 592-Gene NGS Panel that also includes the following genes: BCL6 BCL7A BCL9 BCR ROS1 RPL10 RPL22 RPL5 RPN1 RUNX1
More info about this panelLYMPHOPROLIFERATIVE SYNDROME, AUTOIMMUNE Panel
By Laboratorio de Genetica Clinica SL LYMPHOPROLIFERATIVE SYNDROME, AUTOIMMUNE that also includes the following genes: FAS FASLG CASP10 CASP8 NRAS
More info about this panelAUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME NGS PANEL Panel
By Laboratorio de Genetica Clinica SL AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME NGS PANEL that also includes the following genes: SH2D1A STAT3 FAS FASLG CASP10 CASP8 CTLA4 MAGT1 FADD XIAP
More info about this panelProvidence Personalized Medicine Panel - Solid Tumor Panel
By Providence Regional Laboratories Providence Health and Services Providence Personalized Medicine Panel - Solid Tumor that also includes the following genes: BCR ROS1 RUNX1 SDHA SDHB SDHC SDHD SF3B1 SRSF2 FOXL2
More info about this panelAutoimmune Lymphoproliferative Syndrome Type IIB, Sequencing CASP8 Gene Panel
By Reference Laboratory Genetics
This panel specifically test the CASP8 gene.
More info about this panelAutosomic Autoimmune Lymphoproliferative Syndrome , Panel Massive Sequencing (NGS) 10 Genes Panel
By Reference Laboratory Genetics Autosomic Autoimmune Lymphoproliferative Syndrome , Panel Massive Sequencing (NGS) 10 Genes that also includes the following genes: FAS FASLG CASP10 CASP8 CTLA4 MAGT1 FADD ITK KRAS NRAS
More info about this panelTempus xT assay Panel
By Tempus Labs, Inc. Tempus xT assay that also includes the following genes: BCL6 RIT1 BCL7A BCR ROS1 RPL5 RPS15 RPS6KB1 RUNX1 RXRA
More info about this panelTempus xO assay Panel
By Tempus Labs, Inc. Tempus xO assay that also includes the following genes: BCL6 RHEB RIPK1 RIPK2 RIPK3 RIT1 BCL7A BCL9 BCR ROBO2
More info about this panelCEN4GEN Colorectal cancer: Extended Sequencing Panel Panel
By CEN4GEN Institute for Genomics and Molecular Diagnostics CEN4GEN Colorectal cancer: Extended Sequencing Panel that also includes the following genes: BRAF TCF7L2 TGFBR2 TP53 CASP8 TCERG1 GALNT17 FBXW7 ACVR1B CDC27
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