Van Der Woude Syndrome 2; Vws2

Table of contents:

Description
Related genes
Clinical Features
Incidence and onset information
Alternative Names
Researches and researchers
Gene Panels
Sources and references

Description

Van der Woude syndrome (VWS) is a dominantly inherited developmental disorder characterized by pits and/or sinuses of the lower lip, and cleft lip and/or cleft palate (CL/P, CP). It is the most common cleft syndrome.For a discussion of genetic heterogeneity of van der Woude syndrome, see VWS1 (OMIM ).

Genes related to Van Der Woude Syndrome 2; Vws2

GRHL3

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Clinical Features

Phenotypes and symptoms related to Van Der Woude Syndrome 2; Vws2

Cleft palate
Cleft lip
Cleft upper lip
Cerebral palsy
Anodontia

Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
— No data available about the known clinical features onset.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.

Van Der Woude Syndrome 2; Vws2 Recommended genes panels

Panel Name, Specifity and genes Tested/covered
Van der Woude syndrome 2 (sequence analysis of GRHL3 gene). By CGC Genetics (Portugal). GRHL3 Specificity 100 % Genes 100 %
Van der Woude Syndrome (VWS) via GRHL3 Gene Sequencing with CNV Detection. By PreventionGenetics PreventionGenetics (United States). GRHL3 Specificity 100 % Genes 100 %
Cleft lip, cleft palate and related disorders NGS panel. By Connective Tissue Gene Tests (United States). BMP4, TBX22, SUMO1, TP63, TGDS, SATB2, COL11A1, COL11A2, COL9A1, COL9A2, COL9A3, GRHL3, FOXE1, IRF6, MSX1, NECTIN1 Specificity 7 % Genes 100 %
Cleft lip, cleft palate and related disorders Deletion / Duplication panel. By Connective Tissue Gene Tests (United States). BMP4, TBX22, SUMO1, TP63, TGDS, SATB2, COL11A1, COL11A2, COL9A1, COL9A2, COL9A3, GRHL3, FOXE1, IRF6, MSX1, NECTIN1 Specificity 7 % Genes 100 %
Cleft lip, cleft palate and related disorders Comprehensive panel. By Connective Tissue Gene Tests (United States). BMP4, TBX22, SUMO1, TP63, TGDS, SATB2, COL11A1, COL11A2, COL9A1, COL9A2, COL9A3, GRHL3, FOXE1, IRF6, MSX1, NECTIN1 Specificity 7 % Genes 100 %
Van der Woude syndrome Comprehensive panel. By Connective Tissue Gene Tests (United States). GRHL3, IRF6 Specificity 50 % Genes 100 %
Van der Woude syndrome NGS panel. By Connective Tissue Gene Tests (United States). GRHL3, IRF6 Specificity 50 % Genes 100 %
Van der Woude syndrome Deletion / Duplication panel. By Connective Tissue Gene Tests (United States). GRHL3, IRF6 Specificity 50 % Genes 100 %

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Sources and references

You can check the following sources for additional information.

MESH OMIM Rare Disease Search Engine

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