Phospholipase A2, Group Iva; Pla2g4a

Description

Cytosolic phospholipase A2 (PLA2; {EC 3.1.1.4}) catalyzes the release of arachidonic acid from membrane phospholipids. Arachidonic acid in turn serves as precursor for a wide spectrum of biologic effectors, collectively known as eicosanoids, that are involved in hemodynamic regulation, inflammatory responses, and other cellular processes (summary by Tay et al., 1995). (Eicosanoids are lipid mediators of inflammation; they include a variety of compounds (prostaglandins, thromboxanes, leukotrienes, hydroxy- and epoxy-fatty acids, lipoxins, and isoprostanes) that are derived from the ubiquitous 20-carbon atom arachidonate (20 in Greek is 'eicosa') and a few similar polyunsaturated fatty acids (summary by De Caterina and Zampolli, 2004).)Dennis (1994) reviewed various types of PLA2. The best characterized is the group II PLA2 originally isolated from human synovial fluid (i.e., PLA2G2A; {172411}). Groups I (human pancreatic, PLA2G1B (OMIM ); also found in cobras and kraits), II (synovial; also found in rattlesnakes and vipers), and III (forms of which were described in bee and lizard) are secreted; group IV is cytosolic.

Clinical Features

Phenotypes and symptoms related to Phospholipase A2, Group Iva; Pla2g4a

  • Ventricular hypertrophy
  • Iron deficiency anemia
  • Right ventricular hypertrophy
  • Intestinal bleeding
  • Jejunoileal ulceration

Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
No data available about the known clinical features onset.

Alternative names

Phospholipase A2, Group Iva; Pla2g4a Is also known as cpla2-alpha, phospholipase a2, cytosolic, calcium-dependent, alpha.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.

Sources and references

You can check the following sources for additional information.

OMIM Rare Disease Symptoms Checker

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