Myxoid Liposarcoma

Description

Myxoid liposarcoma is a soft tissue tumor that tends to occur in the limbs (especially the thigh) of patients ranging in age from 35 to 55 years. It is defined by the presence of a hypocellular spindle cell proliferation set in a myxoid background, often with mucin pooling. Lipoblasts tend to be small and often monovacuolated and to cluster around vessels or at the periphery of the lesion (review by Dei Tos, 2000).

Clinical Features

Phenotypes and symptoms related to Myxoid Liposarcoma

  • Neoplasm
  • Abdominal pain
  • Subcutaneous nodule
  • Sarcoma
  • Multiple lipomas
  • Gastrointestinal dysmotility
  • Soft tissue sarcoma
  • Liposarcoma
  • Myxoid liposarcoma

Incidence and onset information

— Based on the latest data available Myxoid Liposarcoma have a estimated incidence of 0.1 per 100k worldwide.


Mendelian

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Myxoid Liposarcoma Recommended genes panels

Panel Name, Specifity and genes Tested/covered
DDIT3.

By Fulgent Genetics Fulgent Genetics in United States.

DDIT3
Specificity
100 %
Genes
50 %
Hemato-oncology chromosomal microarray.

By Pittsburgh Cytogenetics Laboratory University of Pittsburgh Medical Center in United States.

BRCA1, BRCA2, APC, MSH2, MLH1, TP53, COL1A1, RB1, BLM, BRAF, HRAS, ALK, PTCH1, PHOX2B, SUFU, CDH1, FUS, SETD2, KDM5C, PAX3 , (...)

View the complete list with 72 more genes
Specificity
3 %
Genes
100 %
Caris MI TumorSeek 592-Gene NGS Panel.

By Caris Life Sciences in United States.

BRCA1, BRCA2, VHL, APC, MSH2, PMS2, MSH6, MLH1, MUTYH, PTEN, RECQL4, RUNX1, TP53, FOXL2, HNF1A, PPARG, COL1A1, WT1, RB1, SDHAF2 , (...)

View the complete list with 571 more genes
Specificity
1 %
Genes
100 %
Tempus xO assay.

By Tempus Labs, Inc. in United States.

BRCA1, BRCA2, VHL, APC, EPCAM, MSH2, PMS2, MSH6, MLH1, MUTYH, PTEN, RECQL4, RUNX1, TP53, ABCB11, ABCB4, FKBP10, FOXL2, HNF1A, PPARG , (...)

View the complete list with 1693 more genes
Specificity
1 %
Genes
100 %
Amyotrophic Lateral Sclerosis Advanced Evaluation.

By Athena Diagnostics Inc in United States.

OPTN, VCP, SQSTM1, SOD1, FIG4, C9orf72, ALS2, SIGMAR1, FUS, SETX, DCTN1, CHMP2B, TARDBP, ANG, VAPB, PFN1, UBQLN2
Specificity
6 %
Genes
50 %
Nonprevalent Amyotrophic Lateral Sclerosis Advanced Sequencing Evaluation.

By Athena Diagnostics Inc in United States.

OPTN, VCP, SQSTM1, FIG4, ALS2, SIGMAR1, FUS, SETX, DCTN1, CHMP2B, TARDBP, ANG, VAPB, PFN1, UBQLN2
Specificity
7 %
Genes
50 %
Amyotrophic Lateral Sclerosis.

By Knight Diagnostic Laboratories - Molecular Diagnostic Center Oregon Health & Science University in United States.

OPTN, PRPH2, VCP, SOD1, NEFH, FIG4, C9orf72, ATXN2, SPART, ALS2, SIGMAR1, FUS, SETX, DCTN1, CHMP2B, TARDBP, ANG, VAPB, PFN1, UBQLN2 , (...)

View the complete list with 1 more genes
Specificity
5 %
Genes
50 %
Dementia.

By Knight Diagnostic Laboratories - Molecular Diagnostic Center Oregon Health & Science University in United States.

APP, PSEN1, OPTN, VCP, GRN, FIG4, PSEN2, MAPT, APOE, C9orf72, ALS2, FUS, SETX, DCTN1, CHMP2B, TARDBP, ANG, CSF1R, TREM2, PRNP , (...)

View the complete list with 1 more genes
Specificity
5 %
Genes
50 %
Fused in sarcoma (FUS) gene sequencing test.

By Neurogenetics Department Cyprus Institute of Neurology and Genetics in Cyprus.

FUS
Specificity
100 %
Genes
50 %
FUS. Complete sequencing.

By Instituto de Medicina Genomica Instituto de Medicina Genomica in Spain.

FUS
Specificity
100 %
Genes
50 %
SOD1, FUS, TARDBP, ANG, C9orf72. NextGeneDx.Complete sequencing by NGS.

By Instituto de Medicina Genomica Instituto de Medicina Genomica in Spain.

SOD1, C9orf72, FUS, TARDBP, ANG
Specificity
20 %
Genes
50 %
Tremor essential type 4 (sequence analysis of FUS gene).

By CGC Genetics in Portugal.

FUS
Specificity
100 %
Genes
50 %
Frontotemporal dementia (NGS panel for 13 genes).

By CGC Genetics in Portugal.

PSEN1, VCP, GRN, MAPT, FUS, CHMP2B, TARDBP, UBQLN2, CSF1R, CHCHD10, HNRNPA2B1, HNRNPA1, TUBA4A
Specificity
8 %
Genes
50 %
Hereditary dementias (NGS panel for 28 genes).

By CGC Genetics in Portugal.

TYROBP, APP, PSEN1, VCP, GRN, TIMM8A, SNCB, PSEN2, MAPT, APOE, NOTCH3, SNCA, FUS, CHMP2B, TARDBP, UBQLN2, ATP13A2, DNMT1, CSF1R, TREM2 , (...)

View the complete list with 8 more genes
Specificity
4 %
Genes
50 %
Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Sequencing Panel with CNV Detection.

By PreventionGenetics PreventionGenetics in United States.

PSEN1, OPTN, VCP, GRN, SQSTM1, SOD1, PSEN2, MAPT, C9orf72, KIF5A, FUS, SETX, CHMP2B, TARDBP, ANG, VAPB, PFN1, UBQLN2, TBK1, TREM2 , (...)

View the complete list with 5 more genes
Specificity
4 %
Genes
50 %
Amyotrophic Lateral Sclerosis / Motor Neuron Disease via the FUS Gene.

By PreventionGenetics PreventionGenetics in United States.

FUS
Specificity
100 %
Genes
50 %
Classic Amyotrophic Lateral Sclerosis Sequencing Panel with CNV Detection.

By PreventionGenetics PreventionGenetics in United States.

SOD1, C9orf72, FUS, TARDBP
Specificity
25 %
Genes
50 %
Dementia Sequencing Panel with CNV Detection.

By PreventionGenetics PreventionGenetics in United States.

TYROBP, APP, PSEN1, GRN, SQSTM1, PSEN2, MAPT, C9orf72, FUS, CHMP2B, TARDBP, UBQLN2, TREM2
Specificity
8 %
Genes
50 %
Amyotrophic lateral sclerosis and related disorders Comprehensive panel.

By Connective Tissue Gene Tests in United States.

OPTN, VCP, SQSTM1, SOD1, FIG4, SPG11, MATR3, ALS2, SIGMAR1, FUS, SETX, CHMP2B, TARDBP, ANG, VAPB, PFN1, UBQLN2, TBK1, CHCHD10, HNRNPA2B1 , (...)

View the complete list with 4 more genes
Specificity
5 %
Genes
50 %
Amyotrophic lateral sclerosis and related disorders Deletion/ Duplication panel.

By Connective Tissue Gene Tests in United States.

OPTN, VCP, SQSTM1, SOD1, FIG4, SPG11, MATR3, ALS2, SIGMAR1, FUS, SETX, CHMP2B, TARDBP, ANG, VAPB, PFN1, UBQLN2, TBK1, CHCHD10, HNRNPA2B1 , (...)

View the complete list with 4 more genes
Specificity
5 %
Genes
50 %
Amyotrophic lateral sclerosis and related disorders NGS panel.

By Connective Tissue Gene Tests in United States.

OPTN, VCP, SQSTM1, SOD1, FIG4, SPG11, MATR3, ALS2, SIGMAR1, FUS, SETX, CHMP2B, TARDBP, ANG, VAPB, PFN1, UBQLN2, TBK1, CHCHD10, HNRNPA2B1 , (...)

View the complete list with 4 more genes
Specificity
5 %
Genes
50 %
FUS-related amyotrophic lateral sclerosis.

By Institute of Human Genetics Cologne University in Germany.

FUS
Specificity
100 %
Genes
50 %
Neuropathy.

By MGZ Medical Genetics Center in Germany.

TTR, ABHD12, ATP7A, C12orf65, GAA, FBLN5, OPTN, AMACR, POLG, GARS, MFN2, HADHA, VCP, HARS, KARS, SPTLC2, REEP1, HADHB, TYMP, SQSTM1 , (...)

View the complete list with 102 more genes
Specificity
1 %
Genes
50 %
FUS-Related Amyotrophic Lateral Sclerosis.

By MGZ Medical Genetics Center in Germany.

FUS
Specificity
100 %
Genes
50 %
Amyotrophic Lateral Sclerosis (ALS) and Phenocopies.

By MGZ Medical Genetics Center in Germany.

OPTN, VCP, REEP1, SQSTM1, HEXA, GBE1, SOD1, FIG4, SPG11, MATR3, BSCL2, ALS2, FUS, SETX, DCTN1, TARDBP, ANG, VAPB, UBQLN2, BICD2 , (...)

View the complete list with 3 more genes
Specificity
5 %
Genes
50 %
FUS.

By Genome Diagnostics Laboratory University Medical Center Utrecht in Netherlands.

FUS
Specificity
100 %
Genes
50 %
FTD - ALS panel.

By Genome Diagnostics Laboratory University Medical Center Utrecht in Netherlands.

VCP, SMPD1, GRN, SOD1, NPC1, NPC2, FIG4, MAPT, ALS2, FUS, SETX, CHMP2B, TARDBP, ANG, VAPB
Specificity
7 %
Genes
50 %
Tremor essential type 4.

By Centogene AG - the Rare Disease Company in Germany.

FUS
Specificity
100 %
Genes
50 %
Amyotrophic lateral sclerosis type 6.

By Centogene AG - the Rare Disease Company in Germany.

FUS
Specificity
100 %
Genes
50 %
AllNeuro panel.

By Centogene AG - the Rare Disease Company in Germany.

F2, F5, FMR1, HTT, HFE, MTHFR, TTR, UBE3A, VHL, PTEN, AARS2, ABHD12, ACACA, ACAD9, ACADL, ACADM, ACADS, AGL, ACADVL, ACAT1 , (...)

View the complete list with 1185 more genes
Specificity
1 %
Genes
50 %
ALS panel.

By Centogene AG - the Rare Disease Company in Germany.

OPTN, PRPH2, VCP, SOD1, NEFH, FIG4, C9orf72, ATXN2, SPART, ALS2, SIGMAR1, FUS, SETX, DCTN1, CHMP2B, TARDBP, ANG, VAPB, PFN1, UBQLN2 , (...)

View the complete list with 2 more genes
Specificity
5 %
Genes
50 %
Parkinsons disease panel.

By Centogene AG - the Rare Disease Company in Germany.

SPR, HTRA2, PARK7, PINK1, PRKN, SNCB, GBA, TH, PLA2G6, MAPT, GCH1, LRRK2, SNCA, FUS, DCTN1, ATP1A3, SYNJ1, ATP13A2, ATP6AP2, TAF1 , (...)

View the complete list with 10 more genes
Specificity
4 %
Genes
50 %
Amyotrophic Lateral Sclerosis NGS Panel + C9orf72 Repeat Expansion.

By MNG Laboratories (Medical Neurogenetics, LLC.) in United States.

PSEN1, OPTN, VCP, PARK7, SQSTM1, SOD1, FIG4, SPG11, MAPT, C9orf72, MATR3, ALS2, SIGMAR1, FUS, SETX, TARDBP, ANG, VAPB, PFN1, UBQLN2 , (...)

View the complete list with 2 more genes
Specificity
5 %
Genes
50 %
Amyotrophic Lateral Sclerosis NGS Panel.

By MNG Laboratories (Medical Neurogenetics, LLC.) in United States.

PSEN1, OPTN, VCP, PARK7, SQSTM1, SOD1, FIG4, SPG11, MAPT, MATR3, ALS2, SIGMAR1, FUS, SETX, TARDBP, ANG, VAPB, PFN1, UBQLN2, HNRNPA1 , (...)

View the complete list with 1 more genes
Specificity
5 %
Genes
50 %
Hereditary Spastic Paraplegias (HSP) and differential diagnoses Panel.

By CeGaT GmbH in Germany.

MTHFR, ABHD12, ARG1, ATP7A, AUH, C12orf65, PSEN1, OPTN, OPA1, GLB1, ELOVL4, HSPD1, GARS, AFG3L2, PANK2, OPA3, VCP, ALDH18A1, MTPAP, SPR , (...)

View the complete list with 123 more genes
Specificity
1 %
Genes
50 %
Amyotrophic Lateral Sclerosis (ALS) Panel.

By CeGaT GmbH in Germany.

HFE, OPTN, VCP, GRN, PARK7, SQSTM1, SOD1, NEFH, ATXN1, FIG4, SPG11, MAPT, C9orf72, ATXN2, MATR3, SPART, ALS2, SIGMAR1, FUS, SETX , (...)

View the complete list with 34 more genes
Specificity
2 %
Genes
50 %
Frontotemporal Dementia (FTD) Panel.

By CeGaT GmbH in Germany.

PSEN1, OPTN, VCP, GRN, SQSTM1, PSEN2, MAPT, C9orf72, NOTCH3, ATXN2, MATR3, SIGMAR1, FUS, DCTN1, CHMP2B, TARDBP, UBQLN2, TBK1, CSF1R, TREM2 , (...)

View the complete list with 8 more genes
Specificity
4 %
Genes
50 %
Dementia all Panel.

By CeGaT GmbH in Germany.

APP, PSEN1, OPTN, VCP, GRN, SQSTM1, PSEN2, MAPT, APOE, C9orf72, NOTCH3, ATXN2, TBP, MATR3, SIGMAR1, FUS, DCTN1, CHMP2B, TARDBP, UBQLN2 , (...)

View the complete list with 16 more genes
Specificity
3 %
Genes
50 %
Single gene testing FUS.

By CeGaT GmbH in Germany.

FUS
Specificity
100 %
Genes
50 %
FUS - Gene sequencing.

By Clinical Genetics Academic Medical Center in Netherlands.

FUS
Specificity
100 %
Genes
50 %
Amyotrophic lateral sclerosis.

By Laboratory of Human Genetics GENOMED Health Care Center in Poland.

OPTN, GRN, SQSTM1, SOD1, NEFH, FIG4, C9orf72, MATR3, ALS2, SIGMAR1, FUS, SETX, DCTN1, CHMP2B, TARDBP, ANG, VAPB, PFN1, TBK1, CHCHD10 , (...)

View the complete list with 4 more genes
Specificity
5 %
Genes
50 %
Amyotrophic Lateral Sclerosis.

By Asper Biogene Asper Biogene LLC in Estonia.

OPTN, VCP, SQSTM1, SOD1, FIG4, SPG11, MATR3, SPART, ALS2, SIGMAR1, FUS, SETX, CHMP2B, TARDBP, ANG, VAPB, PFN1, UBQLN2, TBK1, CHCHD10 , (...)

View the complete list with 2 more genes
Specificity
5 %
Genes
50 %
Test for FUS-Related Amyotrophic Lateral Sclerosis.

By Secugen SL in Spain.

FUS
Specificity
100 %
Genes
50 %
Amyotrophic lateral sclerosis 06.

By Praxis fuer Humangenetik Wien in Austria.

FUS
Specificity
100 %
Genes
50 %
Tremor, hereditary essential, 4.

By Praxis fuer Humangenetik Wien in Austria.

FUS
Specificity
100 %
Genes
50 %
Amyotrophic lateral sclerosis 06.

By MedGene in Slovakia.

FUS
Specificity
100 %
Genes
50 %
Tremor, hereditary essential, 4.

By MedGene in Slovakia.

FUS
Specificity
100 %
Genes
50 %
Invitae Amyotrophic Lateral Sclerosis Panel.

By Invitae in United States.

OPTN, SOD1, SPG11, ALS2, FUS, DCTN1, TARDBP, VAPB, PFN1, UBQLN2, TFG, TBK1, CHCHD10
Specificity
8 %
Genes
50 %
Invitae Combined Hereditary Dementia and Amyotrophic Lateral Sclerosis Panel.

By Invitae in United States.

APP, PSEN1, OPTN, VCP, GRN, SOD1, SPG11, PSEN2, MAPT, SNCA, ALS2, FUS, DCTN1, TARDBP, VAPB, PFN1, UBQLN2, TFG, TBK1, PRNP , (...)

View the complete list with 1 more genes
Specificity
5 %
Genes
50 %
Invitae Frontotemporal Dementia Panel.

By Invitae in United States.

VCP, GRN, MAPT, FUS, DCTN1, TARDBP, UBQLN2, TBK1, CHCHD10
Specificity
12 %
Genes
50 %
AMYOTROPHIC LATERAL SCLEROSIS A.D. & A.R..

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases in Spain.

OPTN, VCP, SOD1, FIG4, SPART, ALS2, FUS, SETX, TARDBP, ANG, VAPB
Specificity
10 %
Genes
50 %
Frontotemporal dementia.

By GENETAQ Molecular Genetics Centre and Diagnosis of Rare Diseases in Spain.

VCP, GRN, MAPT, SIGMAR1, FUS, CHMP2B, TARDBP, UBQLN2
Specificity
13 %
Genes
50 %
NGS panel - dementia.

By Genome Diagnostics VU University Medical Center in Netherlands.

TYROBP, APP, PSEN1, OPTN, VCP, GRN, SQSTM1, SNCB, SOD1, NEFH, FIG4, PSEN2, MAPT, NOTCH3, SNCA, ALS2, SIGMAR1, FUS, SETX, CHMP2B , (...)

View the complete list with 21 more genes
Specificity
3 %
Genes
50 %
Amyotrophic Lateral Sclerosis NGS Panel.

By Fulgent Genetics Fulgent Genetics in United States.

ABHD12, OPTN, VCP, ACAD8, ABCD1, SOD1, FIG4, C9orf72, ATXN2, ALS2, SIGMAR1, FUS, SETX, DCTN1, CHMP2B, TARDBP, ANG, VAPB, PFN1, UBQLN2 , (...)

View the complete list with 4 more genes
Specificity
5 %
Genes
50 %
FUS.

By Fulgent Genetics Fulgent Genetics in United States.

FUS
Specificity
100 %
Genes
50 %
Onco microarray for MDS/AML.

By Pittsburgh Cytogenetics Laboratory University of Pittsburgh Medical Center in United States.

RUNX1, TP53, WT1, IDH2, KRAS, NRAS, PTPN11, CBL, ALK, GATA2, NF1, FUS, GATA1, DNMT3A, EZH2, TFG, TERT, KMT2A, KIT, ASXL1 , (...)

View the complete list with 40 more genes
Specificity
2 %
Genes
50 %
Dementia Panel.

By Blueprint Genetics in Finland.

UBE3A, APP, PSEN1, VCP, GRN, PSEN2, MAPT, APOE, SNCA, SIGMAR1, FUS, CHMP2B, TARDBP, UBQLN2, CSF1R, TREM2, PRNP, SORL1, RNF216, TUBA4A , (...)

View the complete list with 1 more genes
Specificity
5 %
Genes
50 %
Amyotrophic Lateral Sclerosis Panel.

By Blueprint Genetics in Finland.

OPTN, HSPD1, VCP, REEP1, GRN, SQSTM1, HEXA, GBE1, SOD1, PRF1, FIG4, ATL1, SPG11, SPAST, KIF5A, BSCL2, WASHC5, SPART, ALS2, FUS , (...)

View the complete list with 12 more genes
Specificity
4 %
Genes
50 %
Amyotrophic lateral sclerosis 6, autosomal recessive, with or without frontotemporal dementia.

By Bioarray in Spain.

FUS
Specificity
100 %
Genes
50 %
Amyotrophic Lateral Sclerosis (FUS gene).

By Diagnostic Service Facility University of Antwerp in Belgium.

FUS
Specificity
100 %
Genes
50 %
AMYOTROPHIC LATERAL SCLEROSIS (ALS) (AUTOSOMAL DOMINANT).

By Laboratorio de Genetica Clinica SL in Spain.

VCP, SQSTM1, SOD1, NEFH, FIG4, C9orf72, FUS, SETX, DCTN1, CHMP2B, TARDBP, ANG, VAPB, PFN1, CHCHD10, PRPH
Specificity
7 %
Genes
50 %
AMYOTROPHIC LATERAL SCLEROSIS: ALS NGS PANEL.

By Laboratorio de Genetica Clinica SL in Spain.

OPTN, VCP, SQSTM1, SOD1, NEFH, FIG4, SPG11, MATR3, ALS2, SIGMAR1, FUS, SETX, DCTN1, CHMP2B, TARDBP, ANG, VAPB, PFN1, UBQLN2, CHCHD10 , (...)

View the complete list with 3 more genes
Specificity
5 %
Genes
50 %
DEMENTIA & ALZHEIMER: NGS PANEL.

By Laboratorio de Genetica Clinica SL in Spain.

APP, PSEN1, VCP, GRN, PSEN2, MAPT, APOE, FUS, CHMP2B, TARDBP, CSF1R, TREM2, PRNP, ITM2B
Specificity
8 %
Genes
50 %
Amyotrophic Lateral Sclerosis , Sequencing FUS (TLS-ALS6) Gene.

By Reference Laboratory Genetics in Spain.

FUS
Specificity
100 %
Genes
50 %
Amyotrophic Lateral Sclerosis , Panel Massive Sequencing (NGS) 12 Genes.

By Reference Laboratory Genetics in Spain.

OPTN, VCP, SOD1, FIG4, SPG11, SPART, ALS2, FUS, SETX, TARDBP, ANG, VAPB
Specificity
9 %
Genes
50 %
Hereditary Essential Tremor, Panel Massive Sequencing (NGS) DRD3, TENM4, FUS Genes.

By Reference Laboratory Genetics in Spain.

FUS, DRD3, TENM4
Specificity
34 %
Genes
50 %
Frontotemporal Dementia , Panel Massive Sequencing (NGS) 8 Genes.

By Reference Laboratory Genetics in Spain.

VCP, GRN, MAPT, SIGMAR1, FUS, CHMP2B, TARDBP, UBQLN2
Specificity
13 %
Genes
50 %

Alternate names

Myxoid Liposarcoma Is also known as ;mrcls.


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