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  3. LEUKEMIA, ACUTE LYMPHOBLASTIC; ALL

Leukemia, Acute Lymphoblastic; All

Table of contents:

Description

Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL (Trevino et al., 2009). Genetic Heterogeneity of Acute Lymphoblastic LeukemiaA susceptibility locus for acute lymphoblastic leukemia (ALL1) has been mapped to chromosome 10q21. See also ALL2 (OMIM ), which has been mapped to chromosome 7p12.2; and ALL3 (OMIM ), which is caused by mutation in the PAX5 gene (OMIM ) on chromosome 9p.

Genes related to Leukemia, Acute Lymphoblastic; All

  • FLT3
  • BCR
  • TAL1
  • TAL2
  • ETV6
  • GNB1
  • NBN
  • NUP214
  • BAX

View recommended genes panels

Clinical Features

Phenotypes and symptoms related to Leukemia, Acute Lymphoblastic; All

  • Neoplasm
  • Pain
  • Fever
  • Fatigue
  • Arthralgia
  • Leukemia
  • Bruising susceptibility
  • Acute lymphoblastic leukemia
  • Acute leukemia

Incidence and onset information

— Based on the latest data available LEUKEMIA, ACUTE LYMPHOBLASTIC; ALL have a estimated prevalence of 11 per 100k worldwide.
— No data available about the known clinical features onset.

Researches and researchers

Doctors, researchs, and experts related to Leukemia, Acute Lymphoblastic; All extracted from public data.

Leukemia, Acute Lymphoblastic; All Experts map



Current Researchs and researchers

  • INNSBRUCK — ST. ANNA KINDERKREBSFORSCHUNG

    Investigator of research project - Sponsor of clinical trial - Sponsor of multinational clinical trial

    • Institution/s:
      — St. Anna Kinderkrebsforschung
      — Department für Kinder- und Jugendheilkunde, Medizinische Universität Innsbruck
    • Research area/topic::

      IntReALL 2010: International study for treatment of childhood relapsed ALL 2010 with standard therapy, systematic integration of new agents, and establishment of standardized diagnostic and research - AT


  • WIEN — Pr Renate PANZER-GRÜMAYER

    Investigator of research project

    • Institution/s:
      — St. Anna Kinderkrebsforschung
    • Research area/topic::

      Translational Research in Childhood Acute Lymphoblastic Leukemia (TRANSCALL)


  • WIEN — ST. ANNA KINDERKREBSFORSCHUNG

    Investigator of research project - Sponsor of clinical trial - Sponsor of multinational clinical trial

    • Institution/s:
      — St. Anna Kinderkrebsforschung
      — Department für Kinder- und Jugendheilkunde, Medizinische Universität Innsbruck
    • Research area/topic::

      IntReALL 2010: International study for treatment of childhood relapsed ALL 2010 with standard therapy, systematic integration of new agents, and establishment of standardized diagnostic and research - AT


  • WIEN — Dr Andrea HÖLBL-KOVACIC

    Investigator of research project

    • Institution/s:
      — Department für Biomedizinische Wissenschaften, Veterinärmedizinische Universität Wien
    • Research area/topic::

      Stat5 serine phosphorylation in Bcr/Abl-induced leukemia


  • WIEN — Pr Veronika SEXL

    Investigator of research project

    • Institution/s:
      — Department für Biomedizinische Wissenschaften, Veterinärmedizinische Universität Wien
    • Research area/topic::

      Uncoupling CDK6 from p16INK4A - effects for hematopoiesis and lymphomagenesis


  • GENT — Pr Pieter VAN VLIERBERGHE

    Investigator of research project

    • Institution/s:
      — Ghent University Hospital, Center for Medical Genetics Gent
    • Research area/topic::

      Dynamic interplay between DNA methylation, histone modifications and the activity of super enhancers in the pathogenesis of immature T-ALL


  • TAMPERE — Dr Olli LOHI

    Coordinator of expert centre - Investigator of research project

    • Institution/s:
      — University of Tampere
      — TAYS - Tampere University Hospital
    • Research area/topic::

      The pathogenesis of childhood acute leukemia


  • TURKU — Dr Päivi LÄHTEENMÄKI

    Clinical expert - Investigator of research project

    • Institution/s:
      — Turku University Hospital
    • Research area/topic::

      IntReALL 2010:International study for treatment of childhood relapsed ALL 2010 with standard therapy, systematic integration of new agents, and establishment of standardized diagnostic and research - FI


  • BESANÇON — Pr Pierre-Simon ROHRLICH

    Coordinator of expert centre - Clinical expert - Principal investigator of clinical trial - Investigator of research project

    • Institution/s:
      — CHU de Nice - Hôpital l'Archet 1
      — CHRU de Besançon - Hôpital Jean Minjoz
    • Research area/topic::

      IntReALL 2010: International study for treatment of childhood relapsed ALL 2010 with standard therapy, systematic integration of new agents, and establishment of standardized diagnostic and research - FR


  • MARSEILLE — Pr Pascal AUQUIER

    Investigator of research project - Manager of registry

    • Institution/s:
      — EA 3279 - Laboratoire de santé publique, CHU de Marseille - Hôpital de la Timone
    • Research area/topic::

      multicentric prospective cohort of childhood and teenager leukemia: determinants of health status and quality of life of patients after treatment of an acute leukemia of childhood - LEA


  • NICE — Pr Pierre-Simon ROHRLICH

    Coordinator of expert centre - Clinical expert - Principal investigator of clinical trial - Investigator of research project

    • Institution/s:
      — CHU de Nice - Hôpital l'Archet 1
      — CHRU de Besançon - Hôpital Jean Minjoz
    • Research area/topic::

      IntReALL 2010: International study for treatment of childhood relapsed ALL 2010 with standard therapy, systematic integration of new agents, and establishment of standardized diagnostic and research - FR


  • PARIS — Pr Hervé DOMBRET

    Principal investigator of clinical trial - Coordinator of research network

    • Institution/s:
      — CHU Paris-GH St-Louis Lariboisière F.Widal - Hôpital Saint-Louis
    • Research area/topic::

      Study and research group in adult acute lymphoblastic leukemia


  • PARIS — Dr Vincent GREK

    Investigator of research project - Coordinator of research network

    • Institution/s:
      — Only For Children Pharmaceuticals
    • Research area/topic::

      LOULLA&PHILLA: development of 6-mercaptopurine and methotrexate oral liquid formulations for the maintenance treatment of Acute Lymphoblastic Leukemia in children (coordination)


  • PARIS — Pr André BARUCHEL

    Clinical expert - Principal investigator of clinical trial - Investigator of research project

    • Institution/s:
      — Pôle de pédiatrie médicale, CHU Paris - Hôpital Robert Debré
    • Research area/topic::

      CAL-FB-01: Franco-Belgian protocol of treatment of acute lymphoblastic leukemia in children and adolescents


  • — Institution: Information not provided - DE



    • Institution/s:
      — Institution: Information not provided - DE
    • Research area/topic::

      IRMA-4-ALL : Microfluidic integration of the laboratory processes of the test into a centrifugal test carrier


  • BERLIN — Pr Christian HAGEMEIER

    Coordinator of research network

    • Institution/s:
      — Otto-Heubner-Centrum für Kinder- und Jugendmedizin
    • Research area/topic::

      NGFN plus: Leukemia Network - functional and translational studies on acute lymphoblastic leukemia in childhood -terminated


  • BERLIN — Dr Arend VON STACKELBERG

    Coordinator of expert centre - Clinical expert - Principal investigator of clinical trial - Investigator of research project - Coordinator of research network

    • Institution/s:
      — Charité - Universitätsmedizin Berlin (CVK)
      — Otto-Heubner-Centrum für Kinder- und Jugendmedizin
    • Research area/topic::

      ALL-REZ BFM: Observational study biobank for children with Acute Lymphoblastic Leukemia


  • DRESDEN — Pr Alexander STORCH

    Clinical expert - Investigator of research project - Director of department

    • Institution/s:
      — Universitätsklinikum Carl Gustav Carus an der TU Dresden
      — Klinik und Poliklinik für Neurologie, Universitätsklinikum Carl Gustav Carus an der TU Dresden
    • Research area/topic::

      Longitudinal investigation of hippocampal function and morphology in patients with Acute Lymphocytic Leukemia treated with Chemotherapy: A Monocentric, interdisciplinary pilot study


  • ERLANGEN — Dr Thorsten LANGER

    Investigator of research project

    • Institution/s:
      — Kinder- und Jugendklinik des Universitätsklinikums Erlangen
    • Research area/topic::

      Late Effects Surveillance System (LESS) for oncological diseases in children und adolescents


  • FRANKFURT AM MAIN — Pr Hubert SERVE

    Coordinator of expert centre - Clinical expert - Principal investigator of clinical trial - Investigator of research project - Director of department

    • Institution/s:
      — Zentrum der Inneren Medizin, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt
      — Universitäres Centrum für Tumorerkrankungen (UCT) Frankfurt
    • Research area/topic::

      Pathological gene products and their disease mechanisms: Oncogenic cytokine signaling in acute lymphoblastic leukemia (P2)


  • MANNHEIM — Dr Susanne SAUßELE

    Coordinator of expert centre - Clinical expert - Principal investigator of clinical trial - Investigator of research project - Coordinator of research network

    • Institution/s:
      — III. Medizinische Universitäts-Klinik, Universitätsklinikum Mannheim
      — Universitätsmedizin Mannheim
    • Research area/topic::

      Competence Network 'acute and chronic leukemias'


  • MANNHEIM — Pr Rüdiger HEHLMANN

    Principal investigator of clinical trial - Investigator of research project - Coordinator of research network - Director of department

    • Institution/s:
      — III. Medizinische Universitäts-Klinik, Universitätsklinikum Mannheim
      — Universitätsklinikum Mannheim
    • Research area/topic::

      EUROPEAN LEUKEMIA NET: Strengthen and develop scientific and technological excellence in research and therapy of leukemia (coordination)


  • PERUGIA — Pr Cristina MECUCCI

    Clinical expert - Responsible for diagnostic tests - Investigator of research project - Director of laboratory - Quality manager

    • Institution/s:
      — Università degli Studi di Perugia - Ospedale S. Maria della Misericordia
    • Research area/topic::

      Characterization of chromosomal breakpoints in hematological malignancies using molecular cytogenetics


  • ROMA — Pr Franco LOCATELLI

    Coordinator of expert centre - Principal investigator of clinical trial - Investigator of clinical trial - Investigator of research project

    • Institution/s:
      — Dipartimento di Onco-Ematologia Pediatrica e Medicina Trasfusionale, IRCCS Ospedale Pediatrico Bambino Gesù - SEDE GIANICOLO
    • Research area/topic::

      IntReALL 2010: International study for treatment of childhood relapsed ALL 2010 with standard therapy, systematic integration of new agents, and establishment of standardized diagnostic and research - IT


  • WROCLAW — Pr Ewa GORCZYNSKA

    Investigator of research project

    • Institution/s:
      — Ponadregionalne Centrum Onkologii Dzieciecej PRZYLADEK NADZIEI
    • Research area/topic::

      IntReALL 2010:International study for treatment of childhood relapsed ALL 2010 with standard therapy, systematic integration of new agents, and establishment of standardized diagnostic and research - PL


  • LISBOA — Pr João T BARATA

    Investigator of research project - Director of laboratory

    • Institution/s:
      — Instituto de Medicina Molecular - Faculdade de Medicina da Universidade de Lisboa, Faculdade de Medicina da Universidade de Lisboa
    • Research area/topic::

      Cell-intrinsic and microenvironmental signals intertwined: novel targets for therapeutic intervention in acute lymphoblastic leukemia.


  • PORTO — Mr João LACERDA

    Investigator of research project

    • Institution/s:
      — Hospital de Santo António - Centro Hospitalar do Porto
    • Research area/topic::

      Clinical implications of activation of PI3K/Akt signaling pathway in primary adult acute lymphoblastic leukemia.


  • LUND — Dr Jens NYGREN

    Investigator of research project

    • Institution/s:
      — Lund University
    • Research area/topic::

      Hematopoietic stem cell proliferation in development and in acute lymphoblastic leukemia


  • STOCKHOLM — Dr Annika WALLBERG

    Investigator of research project

    • Institution/s:
      — Karolinska Institutet - Solna
    • Research area/topic::

      Transcriptional mechanisms by Notch and E2A proteins in lymphocyte development and ALL


Leukemia, Acute Lymphoblastic; All Recommended genes panels

Panel Name, Specifity and genes Tested/covered
FLT3 genotyping.

By Molecular Genetics Diagnostic Laboratory Detroit Medical Center University Laboratories (United States).

FLT3
Specificity
100 %
Genes
12 %
MyeloidDx by NGS.

By Molecular Genetics Diagnostic Laboratory Detroit Medical Center University Laboratories (United States).

RUNX1, SF3B1, SRSF2, BRAF, SMC1A, STAG2, TP53, U2AF1, KDM6A, WT1, IKZF1, CALR, CBL, CBLB, SETBP1, FBXW7, CDKN2A, PHF6, ASXL1, CEBPA , (...)

View the complete list with 32 more genes
Specificity
4 %
Genes
23 %
MyeloidDx by NGS.

By Molecular Genetics Diagnostic Laboratory Detroit Medical Center University Laboratories (United States).

RUNX1, SF3B1, SRSF2, BRAF, SMC1A, STAG2, TP53, U2AF1, KDM6A, WT1, IKZF1, CALR, CBL, CBLB, SETBP1, CBLC, FBXW7, CDKN2A, PHF6, CEBPA , (...)

View the complete list with 31 more genes
Specificity
4 %
Genes
23 %
FLT3 Molecular Genetic Testing.

By Michigan State University Clinical Genetics Laboratory Michigan State University (United States).

FLT3
Specificity
100 %
Genes
12 %
Acute myeloid leukemia (AML, sequence analysis of FLT3 gene).

By CGC Genetics (Portugal).

FLT3
Specificity
100 %
Genes
12 %
Detection of ITD and TKD mutations on FLT3 gene.

By CGC Genetics (Portugal).

FLT3
Specificity
100 %
Genes
12 %
FLT3 ITD, NPM1 targeted mutation testing.

By Molecular Diagnostics Laboratory University of Toledo Medical Center (United States).

FLT3, NPM1
Specificity
50 %
Genes
12 %
Myeloid Tumor Panel.

By Centogene AG - the Rare Disease Company (Germany).

RUNX1, SF3B1, SRSF2, BRAF, SMC1A, STAG2, TP53, U2AF1, KDM6A, WT1, IKZF1, CALR, CBL, CBLB, SETBP1, CBLC, FBXW7, CDKN2A, PHF6, ASXL1 , (...)

View the complete list with 33 more genes
Specificity
4 %
Genes
23 %

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Sources and references

You can check the following sources for additional information.

OMIM ORPHANET Rare Disease Symptoms Checker

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