Hypogonadotropic Hypogonadism 24 Without Anosmia; Hh24

Description

Subnormal concentration of follicle stimulating hormone.

Genes related to Hypogonadotropic Hypogonadism 24 Without Anosmia; Hh24

FSHB

Clinical Features

Top most frequent phenotypes and symptoms related to Hypogonadotropic Hypogonadism 24 Without Anosmia; Hh24

Abnormality of metabolism/homeostasis
Delayed skeletal maturation
Delayed puberty
Infertility
Decreased testicular size
Amenorrhea
Primary amenorrhea
Hypogonadotrophic hypogonadism
Azoospermia
Decreased muscle mass

And another 19 symptoms. If you need more information about this disease we can help you.

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Incidence and onset information

— Not enough data available about incidence and published cases.

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Hypogonadotropic Hypogonadism 24 Without Anosmia; Hh24 Recommended genes panels

Panel Name, Specifity and genes Tested/covered
Hypogonadotropic Hypogonadism Sequencing Panel. By Genetic Services Laboratory University of Chicago in United States. CHD7, NR0B1, GNRH1, FGFR1, TACR3, KISS1R, GNRHR, PROKR2, PROK2, FGF8, ANOS1, IL17RD, NSMF, FEZF1, LHB, FSHB, FGF17, WDR11, TAC3 Specificity 6 % Genes 100 %
Hypogonadotropic Hypogonadism Deletion/Duplication Panel. By Genetic Services Laboratory University of Chicago in United States. CHD7, NR0B1, GNRH1, FGFR1, TACR3, KISS1R, GNRHR, PROKR2, PROK2, FGF8, ANOS1, IL17RD, NSMF, FEZF1, LHB, FSHB, FGF17, WDR11, TAC3 Specificity 6 % Genes 100 %
Follicle-stimulating hormone deficiency, isolated (sequence analysis of FSHB gene). By CGC Genetics in Portugal. FSHB Specificity 100 % Genes 100 %
Hypogonadism hypogonadotropic (NGS panel of 26 genes). By CGC Genetics in Portugal. HESX1, CHD7, NR0B1, GNRH1, FGFR1, TACR3, KISS1R, GNRHR, PROKR2, PROK2, FGF8, ANOS1, IL17RD, SEMA3A, NSMF, FEZF1, LHB, FSHB, FGF17, WDR11 , (...) View the complete list with 6 more genes Panel GTR000556935 complete gene list HESX1, CHD7, NR0B1, GNRH1, FGFR1, TACR3, KISS1R, GNRHR, PROKR2, PROK2, FGF8, ANOS1, IL17RD, SEMA3A, NSMF, FEZF1, LHB, FSHB, FGF17, WDR11, TAC3, KISS1, FLRT3, DUSP6, SPRY4, HS6ST1 Specificity 4 % Genes 100 %
Hypogonadism hypogonadotropic (NGS panel of 26 genes). By CGC Genetics in Portugal. HESX1, CHD7, NR0B1, GNRH1, FGFR1, TACR3, KISS1R, GNRHR, PROKR2, PROK2, FGF8, ANOS1, IL17RD, SEMA3A, NSMF, FEZF1, LHB, FSHB, FGF17, WDR11 , (...) View the complete list with 6 more genes Panel GTR000557377 complete gene list HESX1, CHD7, NR0B1, GNRH1, FGFR1, TACR3, KISS1R, GNRHR, PROKR2, PROK2, FGF8, ANOS1, IL17RD, SEMA3A, NSMF, FEZF1, LHB, FSHB, FGF17, WDR11, TAC3, KISS1, FLRT3, DUSP6, SPRY4, HS6ST1 Specificity 4 % Genes 100 %
Male and Female Infertility via the FSHB Gene. By PreventionGenetics PreventionGenetics in United States. FSHB Specificity 100 % Genes 100 %
Hypogonadotropic Hypogonadism/Kallmann Sequencing Panel with CNV Detection. By PreventionGenetics PreventionGenetics in United States. SOX2, HESX1, CHD7, LEP, LEPR, PCSK1, PROP1, NR0B1, GNRH1, FGFR1, TACR3, KISS1R, GNRHR, PROKR2, PROK2, FGF8, ANOS1, SOX10, SEMA3E, SOX3 , (...) View the complete list with 17 more genes Panel GTR000558468 complete gene list SOX2, HESX1, CHD7, LEP, LEPR, PCSK1, PROP1, NR0B1, GNRH1, FGFR1, TACR3, KISS1R, GNRHR, PROKR2, PROK2, FGF8, ANOS1, SOX10, SEMA3E, SOX3, LHX4, LHX3, IL17RD, SEMA3A, NSMF, FEZF1, FSHB, FGF17, WDR11, TAC3, KISS1, FLRT3, DUSP6, SPRY4, HS6ST1, AXL, CCDC141 Specificity 3 % Genes 100 %
Female Infertility Sequencing Panel with CNV Detection. By PreventionGenetics PreventionGenetics in United States. HFE, FOXL2, STAR, WT1, ARL6, MKKS, TTC8, TRIM32, CYP11A1, GALT, BBS7, BBS5, BBS12, BBS9, BBS10, BBS4, BBS1, BBS2, SOX2, CYP17A1 , (...) View the complete list with 83 more genes Panel GTR000553211 complete gene list HFE, FOXL2, STAR, WT1, ARL6, MKKS, TTC8, TRIM32, CYP11A1, GALT, BBS7, BBS5, BBS12, BBS9, BBS10, BBS4, BBS1, BBS2, SOX2, CYP17A1, HESX1, WWOX, AIRE, AR, ARX, CHD7, EIF2B1, LEP, LEPR, PCSK1, SRY, FGFR2, PROP1, EIF2B5, LMNA, EIF2B3, EIF2B2, EIF2B4, NR0B1, GNRH1, FGFR1, LHCGR, TACR3, KISS1R, GNRHR, PROKR2, PROK2, FGF8, ANOS1, ATRX, CLPP, SOX10, SEMA3E, SOX3, POR, SOX9, NR5A1, HSD17B3, LHX4, LHX3, SRD5A2, CYP19A1, IL17RD, DHH, SEMA3A, WNT4, MAP3K1, NSMF, RSPO1, FEZF1, MCM8, HFM1, PSMC3IP, FIGLA, NOBOX, BMP15, FSHR, MAMLD1, LHB, FSHB, FGF17, WDR11, TAC3, KISS1, NR3C1, FLRT3, DUSP6, SPRY4, HS6ST1, NUP107, ZP1, MCM9, AXL, CCDC141, SYCE1, DMRT1, DMRT2, SOHLH1, PADI6, PRLR, STAG3, AKR1C4, CBX2 Specificity 1 % Genes 100 %
Male Infertility Sequencing Panel with CNV Detection. By PreventionGenetics PreventionGenetics in United States. HFE, FOXL2, STAR, WT1, ARL6, MKKS, TTC8, TRIM32, CYP11A1, BBS7, BBS5, BBS12, BBS9, BBS10, BBS4, BBS1, BBS2, SOX2, CYP17A1, HESX1 , (...) View the complete list with 86 more genes Panel GTR000553213 complete gene list HFE, FOXL2, STAR, WT1, ARL6, MKKS, TTC8, TRIM32, CYP11A1, BBS7, BBS5, BBS12, BBS9, BBS10, BBS4, BBS1, BBS2, SOX2, CYP17A1, HESX1, WWOX, AIRE, AR, ARX, CFTR, CHD7, LEP, LEPR, PCSK1, SRY, FGFR2, PROP1, NR0B1, GNRH1, FGFR1, LHCGR, TACR3, KISS1R, GNRHR, PROKR2, PROK2, FGF8, ANOS1, ATRX, SOX10, SEMA3E, SOX3, POR, SOX9, DNAH1, SYCP3, NR5A1, ADGRG2, HSD17B3, LHX4, LHX3, SRD5A2, GATA4, CYP19A1, IL17RD, DHH, SEMA3A, WNT4, MAP3K1, NSMF, RSPO1, FEZF1, MAMLD1, AMH, AMHR2, LHB, FSHB, FGF17, WDR11, TAC3, KISS1, SPATA16, PICK1, AURKC, NANOS1, CATSPER1, FLRT3, DUSP6, SPRY4, HS6ST1, AXL, CCDC141, SYCE1, DMRT1, DMRT2, AKR1C4, CBX2, BRDT, CFAP44, CFAP43, INSL3, KLHL10, PLCZ1, TAF4B, NPAS2, SEPT12, SLC26A8, TEX11, SUN5, ZMYND15, GALNTL5 Specificity 1 % Genes 100 %
Disorders of Sex Development (DSD) and Infertility Sequencing Panel with CNV Detection. By PreventionGenetics PreventionGenetics in United States. HFE, FOXL2, STAR, WT1, HNF1B, HSD17B4, PITX2, ARL6, MKKS, TTC8, TRIM32, CYP11B1, TMEM70, HSD3B2, CYP11A1, HCCS, BCOR, CYB5A, GALT, BBS7 , (...) View the complete list with 186 more genes Panel GTR000553215 complete gene list HFE, FOXL2, STAR, WT1, HNF1B, HSD17B4, PITX2, ARL6, MKKS, TTC8, TRIM32, CYP11B1, TMEM70, HSD3B2, CYP11A1, HCCS, BCOR, CYB5A, GALT, BBS7, BBS5, BBS12, MKS1, BBS9, BBS10, BBS4, BBS1, BBS2, SOX2, CYP17A1, HESX1, WWOX, FGFR3, AIRE, AR, ARX, CFTR, CHD7, CREBBP, DHCR7, EIF2B1, LEP, LEPR, PCSK1, PTPN11, SOS1, SRY, FGFR2, CDKN1C, GPC3, HBA1, PROP1, PEX1, EIF2B5, FIG4, LMNA, EIF2B3, EIF2B2, EIF2B4, NR0B1, GNRH1, FGFR1, LHCGR, TACR3, KISS1R, GNRHR, PROKR2, PROK2, FGF8, ANOS1, FLNA, ATRX, OPHN1, SETBP1, ZEB2, SALL1, CLPP, SOX10, SEMA3E, MID1, MED12, FAT4, WDR35, SOX3, POR, SOX9, PCNT, GLI3, TP63, DNAH1, FBXL4, RIPK4, SYCP3, NR5A1, FGF10, ADGRG2, HSD17B3, LHX4, LHX3, SRD5A2, EFNB1, GATA4, CEP41, EVC, EVC2, RBBP8, DHCR24, BMP4, B3GLCT, EPG5, UBR1, WNT5A, CYP19A1, DYNC2H1, GRIP1, ESCO2, FREM2, HOXA13, IL17RD, DHH, DNMT3B, ROR2, SEMA3A, TBX15, WNT4, WNT7A, TSPYL1, CCNQ, ZFPM2, MAP3K1, NSMF, RSPO1, FRAS1, IRF6, ICK, FEZF1, NEK1, SPECC1L, WDR60, MCM8, HFM1, PSMC3IP, FIGLA, NOBOX, BMP15, FSHR, MAMLD1, AMH, AMHR2, LHB, FSHB, FGF17, WDR11, TAC3, CUL7, PDE4D, PTDSS1, KISS1, TRAIP, TWIST2, NR3C1, SPATA16, PICK1, AURKC, NANOS1, CATSPER1, FLRT3, DUSP6, SPRY4, HS6ST1, NUP107, ZP1, MCM9, BMP7, HOXB6, HOXA4, AXL, CCDC141, SYCE1, DMRT1, DMRT2, SOHLH1, PADI6, PRLR, STAG3, AKR1C4, CBX2, BRDT, CFAP44, CFAP43, INSL3, KLHL10, PLCZ1, TAF4B, NPAS2, SEPT12, SLC26A8, TEX11, SUN5, ZMYND15, GALNTL5, HHAT, BNC2, ATF3, TOE1, CHD4 Specificity 1 % Genes 100 %
Disorders of Sex Development (DSD) Sequencing Panel with CNV Detection. By PreventionGenetics PreventionGenetics in United States. HFE, FOXL2, STAR, WT1, HNF1B, HSD17B4, PITX2, ARL6, MKKS, TTC8, TRIM32, CYP11B1, TMEM70, HSD3B2, CYP11A1, HCCS, BCOR, CYB5A, BBS7, BBS5 , (...) View the complete list with 138 more genes Panel GTR000553216 complete gene list HFE, FOXL2, STAR, WT1, HNF1B, HSD17B4, PITX2, ARL6, MKKS, TTC8, TRIM32, CYP11B1, TMEM70, HSD3B2, CYP11A1, HCCS, BCOR, CYB5A, BBS7, BBS5, BBS12, MKS1, BBS9, BBS10, BBS4, BBS1, BBS2, SOX2, CYP17A1, HESX1, WWOX, FGFR3, AR, ARX, CHD7, CREBBP, DHCR7, LEP, LEPR, PCSK1, PTPN11, SOS1, SRY, FGFR2, CDKN1C, GPC3, HBA1, PROP1, PEX1, FIG4, LMNA, NR0B1, GNRH1, FGFR1, LHCGR, TACR3, KISS1R, GNRHR, PROKR2, PROK2, FGF8, ANOS1, FLNA, ATRX, OPHN1, SETBP1, ZEB2, SALL1, SOX10, MID1, MED12, FAT4, WDR35, SOX3, POR, SOX9, PCNT, GLI3, TP63, FBXL4, RIPK4, NR5A1, FGF10, HSD17B3, LHX4, LHX3, SRD5A2, EFNB1, GATA4, CEP41, EVC, EVC2, RBBP8, DHCR24, BMP4, B3GLCT, EPG5, UBR1, WNT5A, CYP19A1, DYNC2H1, GRIP1, ESCO2, FREM2, HOXA13, IL17RD, DHH, DNMT3B, ROR2, SEMA3A, TBX15, WNT4, WNT7A, TSPYL1, CCNQ, ZFPM2, MAP3K1, NSMF, RSPO1, FRAS1, IRF6, ICK, FEZF1, NEK1, SPECC1L, WDR60, PSMC3IP, BMP15, FSHR, MAMLD1, AMH, AMHR2, LHB, FSHB, WDR11, TAC3, CUL7, PDE4D, PTDSS1, KISS1, TRAIP, TWIST2, NR3C1, HS6ST1, MCM9, BMP7, HOXB6, HOXA4, DMRT1, DMRT2, AKR1C4, CBX2, INSL3, HHAT, BNC2, ATF3, TOE1, CHD4 Specificity 1 % Genes 100 %
Infertility panel. By Centogene AG - the Rare Disease Company in Germany. LHCGR, FSHR, LHB, FSHB Specificity 25 % Genes 100 %
Follicle-stimulating hormone deficiency, isolated. By Centogene AG - the Rare Disease Company in Germany. FSHB Specificity 100 % Genes 100 %
Single gene testing FSHB. By CeGaT GmbH in Germany. FSHB Specificity 100 % Genes 100 %
Male Factor Infertility. By Asper Biogene Asper Biogene LLC in Estonia. FMR1, CFTR, GNRHR, DNAH11, DNAH5, DNAI1, FSHB, INSL3, UTP14C, USP26, TEKT2, RBMXL2, PRM3, PRM2, PRM1, PRDM9, NLRP14, ESR2, DDX25, XIST , (...) View the complete list with 1 more genes Panel GTR000520059 complete gene list FMR1, CFTR, GNRHR, DNAH11, DNAH5, DNAI1, FSHB, INSL3, UTP14C, USP26, TEKT2, RBMXL2, PRM3, PRM2, PRM1, PRDM9, NLRP14, ESR2, DDX25, XIST, RXFP2 Specificity 5 % Genes 100 %
FSHB. By Fulgent Genetics Fulgent Genetics in United States. FSHB Specificity 100 % Genes 100 %
Premature Ovarian Failure (POF) and Related Disorders , Panel Massive Sequencing (NGS) 14 Genes. By Reference Laboratory Genetics in Spain. FOXL2, STAR, CYP17A1, NR5A1, CYP19A1, WNT4, PSMC3IP, FIGLA, NOBOX, BMP15, FSHR, FSHB, POF1B, DIAPH2 Specificity 8 % Genes 100 %
Kallmann Syndrome , Panel Massive Sequencing (NGS) 20 Genes. By Reference Laboratory Genetics in Spain. CHD7, NR0B1, GNRH1, FGFR1, TACR3, KISS1R, GNRHR, PROKR2, PROK2, FGF8, ANOS1, SEMA3A, NSMF, LHB, FSHB, WDR11, TAC3, KISS1, POLR3B, HS6ST1 Specificity 5 % Genes 100 %
Phosphorus Male Infertility Panel. By Phosphorus Diagnostics LLC in United States. AR, CFTR, SRY, LHCGR, FSHR, FSHB, DPY19L2, AURKC, CATSPER1, USP9Y Specificity 10 % Genes 100 %
Phosphorus Female Infertility Panel. By Phosphorus Diagnostics LLC in United States. F2, F5, FMR1, FOXL2, CYP11A1, GALT, CYP17A1, LHCGR, KISS1R, GNRHR, NR5A1, GNAS, PROS1, PROC, CYP19A1, NOBOX, BMP15, FSHR, FSHB, SERPINC1 , (...) View the complete list with 6 more genes Panel GTR000558446 complete gene list F2, F5, FMR1, FOXL2, CYP11A1, GALT, CYP17A1, LHCGR, KISS1R, GNRHR, NR5A1, GNAS, PROS1, PROC, CYP19A1, NOBOX, BMP15, FSHR, FSHB, SERPINC1, ZP1, STAG3, CAPN10, GDF9, THADA, DENND1A Specificity 4 % Genes 100 %

Alternate names

Hypogonadotropic Hypogonadism 24 Without Anosmia; Hh24 Is also known as follicle-stimulating hormone deficiency, isolated;isolated fsh deficiency.

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