1. Mendelian
  2. Rare Diseases
  3. BLOOD GROUP, DOMBROCK SYSTEM; DO

Blood Group, Dombrock System; Do

Table of contents:

Description

The DO blood group was discovered with serologic tests of blood and named after the original DO(a) serum donor in 1965. Nearly a decade passed before the discovery of the antithetical antigen, DO(b). The DO(a) and DO(b) antigens reside on a glycosylphosphatidylinositol (GPI)-anchored red blood cell (RBC) membrane glycoprotein, ART4, that also carries 3 high-incidence antigens, Gregory (Gy(a)), Holley (Hy), and Joseph (Jo(a)). The DO blood group is not associated with hemolytic disease of the newborn, but severe hemolytic transfusion reactions due to the presence of anti-DO antibodies have been reported among adults (summary by Gubin et al. (2000) and Lucien et al. (2002)).

Genes related to Blood Group, Dombrock System; Do

  • ART4

View recommended genes panels

Clinical Features

Phenotypes and symptoms related to Blood Group, Dombrock System; Do

  • Pain
  • Fever
  • Back pain
  • Low back pain

Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
— No data available about the known clinical features onset.

Alternative names

Blood Group, Dombrock System; Do Is also known as dombrock blood group system.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.

Blood Group, Dombrock System; Do Recommended genes panels

Panel Name, Specifity and genes Tested/covered
Red Cell Genotyping Panel.

By BloodCenter of Wisconsin Diagnostic Laboratories BloodCenter of Wisconsin, part of Versiti (United States).

RHCE, RHD, SLC14A1, ACKR1, GYPA, GYPB, KEL, BCAM, ART4
Specificity
12 %
Genes
100 %
ART4.

By Fulgent Genetics Fulgent Genetics (United States).

ART4
Specificity
100 %
Genes
100 %

You can get up to -6 more panels with our dedicated tool

Learn more

Sources and references

You can check the following sources for additional information.

OMIM Rare Disease Search Engine

If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like WOLF-HIRSCHHORN SYNDROME MYOPATHY, TUBULAR AGGREGATE, 1; TAM1 MULTICENTRIC CARPOTARSAL OSTEOLYSIS SYNDROME; MCTO IVIC SYNDROME BARDET-BIEDL SYNDROME 21; BBS21 DYSTONIA 12; DYT12 POSTAXIAL ACROFACIAL DYSOSTOSIS; POADS